The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide.
Visit the Council's website to learn more.
Submissions from 2011
Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood–testis-barrier-hemidesmosome functional axis in the testis, C. Yan Cheng, Pearl P.Y. Lie, Ka-Wai Mok, Yan Ho Cheng, Elissa W.P. Wong, Jayakanthan Mannu, Premendu P. Mathur, Helen H.N. Yan, and Dolores D. Mruk
Interleukin-1α is a regulator of the blood-testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas, Takeshi Maruo, Noriyuki Ohara, Shigeki Yoshida, Koji Nakabayashi, Hiroko Sasaki, Qin Xu, Hiroya Matsuo, Régine Sitruk-Ware, and Hideto Yamada
Male contraception: Where do we go from here?, C. Yan Cheng and Dolores D. Mruk
Metabolic effects of contraceptive steroids, Régine Sitruk-Ware and Anita Nath
Myeloid dendritic cells in HIV-1 infection, Nina Derby, Elena Martinelli, and Melissa Robbiani
Nomegestrol acetate, a novel progestogen for oral contraception, Alfred O. Mueck and Régine Sitruk-Ware
P-glycoprotein regulates blood–testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK), Linlin Su, Dolores D. Mruk, Wing Yee Lui, Will M. Lee, and C. Yan Chen
Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Xiang Xiao, Michelle W.M. Li, Wing Yee Lui, and Will M. Lee
Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors, Rashad Hussain, Martine El-Etr, Ouardia Gaci, Jennifer Rakotomamonjy, Wendy B. Macklin, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, and Abdel M. Ghoumari
Regulation of blood–testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Dolores D. Mruk, Helen H.N. Yan, Ka-Wai Mok, Jayakanthan Mannu, Premendu P. Mathur, Wing-Yee Lui, Will M. Lee, Michele Bonanomi, and Bruno Silvestrini
Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3, C. Yan Cheng and Dolores D. Mruk
Role of 11β-OH-C_19 and C_21 steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells, Syed A. Latif, Mae Shen, Renshan Ge, Chantal M. Sottas, Matthew P. Hardy, and David J. Morris
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids, Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, and Peter D. Sun
Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis, Dolores D. Mruk and C. Yan Cheng
The biology of the desmosome-like junction: A versatile anchoring junction and signal transducer in the seminiferous epithelium, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances, Binghai Zhao, Qing-Quan Lian, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
The myotubularin family of lipid phosphatases in disease and in spermatogenesis, Dolores D. Mruk and C. Yan Cheng
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques, Rachel Singer, Nina Derby, Aixa Rodriguez, Larisa Kizima, Jessica Kenney, Meropi Aravantinou, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes, Michelle K.Y. Siu, Ching-hang Wong, Weiliang Xia, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Validation of a dye stain assay for vaginally inserted hydroxyethylcellulose-filled microbicide applicators, Lauren L. Katzen, José Fernández-Romero, Avina Sarna, Kailapuri G. Murugavel, Daniel Gawarecki, Thomas Zydowsky, and Barbara Mensch
Submissions from 2010
7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat leydig cells, Guo-Xin Hu, Qing-Quan Lian, Bing-Bing Chen, Pramod Vishwanath Prasad, Narender Kumar, Zhi-Qiang Zheng, and Renshan Ge
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo, Linlin Su, C. Yan Cheng, and Dolores D. Mruk
A local autocrine axis in the testes that regulates spermatogenesis, C. Yan Cheng and Dolores D. Mruk
A tonsillar polyICLC/At-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation, Panagiotis Vagenas, Meropi Aravantinou, Vennansha G. Williams, Edith Jasny, Michael Piatak Jr., Jeffrey D. Lifson, Andres M. Salazar, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Claudin and occludin expression and function in the seminiferous epithelium, Carla M.K. Morrow, Dolores D. Mruk, C. Yan Cheng, and R. A. Hess
Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo, Lifei Liu, Liqin Zhao, Hongyun She, Shuhua Chen, Jun Ming Wang, Charisse Wong, Kelsey McClure, Régine Sitruk-Ware, and Roberta Diaz Brinton
Connexin 43 is critical to maintain the homeostasis of the blood–testis barrier via its effects on tight junction reassembly, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3, Guo-Xin Hu, Guang Liang, Yanhui Chu, Xiao-Kun Li, Qing-Quan Lian, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, and Renshan Ge
Cytoskeletal dynamics and spermatogenesis, Pearl P.Y. Lie, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Deletion of the Igf1 gene: Suppressive effects on adult Leydig cell development, Guo-Xin Hu, Han Lin, Guo-Rong Chen, Bing-Bing Chen, Qing-Quan Lian, Dianne O. Hardy, Barry R. Zirkin, and Renshan Ge
Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood–testis barrier, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women, Gabriela Noe; Régine Sitruk-Ware; Fernando Zegers-Hochschild; Bruce Variano; Juan Carlos Montero; P. Arriagada; A. Li; Frank Z. Stanczyk; J.C. Felix; Daniel R. Mishell, Jr.; and Horacio B. Croxatto
Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells, Ye-Chen Xiao, Ya-Dong Huang, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Inhibition of 3β- and 17β-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid, Binghai Zhao, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Inhibition of LH-stimulated androgen production in rat immature Leydig cells: Effects on nuclear receptor steroidogenic factor 1 by FGF2, Ye-Chen Xiao, Dianne O. Hardy, Chantal M. Sottas, Xiao-Kun Li, and Renshan Ge
Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques, Robert M. Brenner, Ov D. Slayden, Anita Nath, Yun-yen Tsong, and Régine Sitruk-Ware
In vivo binding and retention of CD4-Specific DARPin 57.2 in macaques, Pavel Pugach, Anders Krarup, Agegnehu Gettie, Marcelo Kuroda, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Alexandra Trkola, and Melissa Robbiani
New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk
New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk
No-needle local anesthesia for adult male circumcision, Yifeng Peng, Puneet Masson, Philip S. Li, Yue Chang, Long Tian, Richard Lee, Howard H. Kim, David C. Sokal, and Marc Goldstein
Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats, Shang-Qin Chen, Jin-Ni Chen, Xiao-Hong Cai, Guo-Rong Chen, Yuan Gao, Renshan Ge, Hai-Shan Wu, Zhen-Lang Lin, and Jing Lin
Progesterone vaginal ring for contraceptive use during lactation, Anita Nath and Régine Sitruk-Ware
Regulation of blood–testis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event, Elissa W.P. Wong, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances, C. Yan Cheng, Elissa W.P. Wong, Helen H.N. Yan, and Dolores D. Mruk
Restricted Arp3 expression in the testis prevents blood–testis barrier disruption during junction restructuring at spermatogenesis, Pearl P.Y. Lie, Apple Y.N. Chan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Sertoli-germ cell junctions in the testis: A review of recent data, Ilona A. Ropera, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk
Single-dose Pharmacokinetics of Nestorone®, a potential female-contraceptive, Pramod Vishwanath Prasad, Mohammad Bashir, Régine Sitruk-Ware, and Narender Kumar
State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices, Irving Sivin and I. Batar
State-of-the-art of non-hormonal methods of contraception: I. Mechanical barrier contraception, I. Batar and Irving Sivin
State-of-the-art of non-hormonal methods of contraception: IV. Natural family planning, G. Freundl, Irving Sivin, and I. Batar
State-of-the-art of non-hormonal methods of contraception: IV. Natural family planning, G. Freundl, Irving Sivin, and I. Batar
Structure-dependent inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 activities by phthalates, Binghai Zhao, Yanhui Chu, Ya-Dong Huang, Dianne O. Hardy, Shaoqiang Lin, and Renshan Ge
The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis, Susanna Kwitny, Angela V. Klaus, and Gary R. Hunnicutt
The biology of spermatogenesis: The past, present and future, C. Yan Cheng and Dolores D. Mruk
The use of newer progestins for contraception, Régine Sitruk-Ware and Anita Nath
The use of newer progestins for contraception, Régine Sitruk-Ware and Anita Nath
Tight junctions in the testis: New perspectives, Dolores D. Mruk and C. Y. Cheng
Submissions from 2009
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis, Shengyi Sun, Elissa W.P. Wong, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng
14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes, Elissa W.P. Wong, Shengyi Sun, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng
Acceptability of a Carrageenan-based candidate vaginal microbicide and matching placebo: Findings from a Phase II safety trial among women in Chiang Rai, Thailand, Heidi E. Jones, Supaporn Chaikummao, Janneke van de Wijgert, Barbara Friedland, Chomnad Manopaiboon, Paisit Witwatwongwana, Mayuree Wankrairot, Nartlada Chantharojwong, and Peter H. Kilmarx
Activins regulate 17β-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells, Beata Bak, Laura Carpio, Jinjing L. Kipp, Pankaj Lamba, Ying Wang, Renshan Ge, Matthew P. Hardy, Kelly E. Mayo, and Daniel J. Bernard
A decision analysis of treatments for nonobstructive azoospermia associated with varicocele, Richard Lee, Philip S. Li, Marc Goldstein, Glenn Schattman, and Peter N. Schlegel
Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study, Guo-Xin Hu, Lu-Feng Hu, Dai-Zheng Yang, Jun-Wei Li, Guo-Rong Chen, Bing-Bing Chen, Dolores D. Mruk, Michele Bonanomi, Bruno Silvestrini, C. Yan Cheng, and Renshan Ge
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy, Federica Crostarosa, Meropi Aravantinou, Onome J. Akpogheneta, Edith Jasny, Andrew Shaw, Jessica Kenney, Michael Piatak Jr., Jeffrey D. Lifson, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Thomas M. Zydowsky, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective, C. Yan Cheng and Dolores D. Mruk
An in vivo study on adjudin and blood-testis barrier dynamics, Ilona A. Kopera, Linlin Su, Barbara Bilínska, C. Yan Cheng, and Dolores D. Mruk
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model, Erica R. Siu, Elissa W.P. Wong, Dolores D. Mruk, K.L. Sze, Catarina S. Porto, and C. Yan Cheng
Cadmium-induced testicular injury, Erica R. Siu, Dolores D. Mruk, Catarina S. Porto, and C. Yan Cheng
Central modifications of allopregnanolone and β-endorphin following subcutaneous administration of Nestorone, E. Lenzi, N. Pluchino, S. Begliuomini, E. Casarosa, S. Merlini, A. Giannini, M. Luisi, Narender Kumar, Régine Sitruk-Ware, and A.R. Genazzani
Characterization of a novel gain of function glucocorticoid receptor knock-in mouse, Junhui Zhang, Renshan Ge, Catherine Matte-Martone, Julie Goodwin, Warren D. Shlomchik, Mark J. Mamula, Ali Kooshkabadi, Matthew P. Hardy, and David Geller
Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men, Vahid Mahabadi, John K. Amory, Ronald S. Swerdloff, William J. Bremner, Stephanie T. Page, Régine Sitruk-Ware, Peter D. Christensen, Narender Kumar, Yun-yen Tsong, Diana Blithe, and Christina Wang
Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Coordinating cellular events during spermatogenesis: A biochemical model, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Cytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8-dependent signaling: A novel survival pathway revealed, Yong-Guang Gong, Yi-Qiu Wang, Min Gu, Ming-Ming Feng, Wei Zhang, and Renshan Ge
Different cardiovascular effects of progestins according to structure and activity, Anita Nath and Régine Sitruk-Ware
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Distribution, metabolism and excretion of a synthetic androgen 7α-methyl-19-nortestosterone, a potential male-contraceptive, Pramod Vishwanath Prasad, Ramamani Arumugam, Mark Willman, Renshan Ge, Régine Sitruk-Ware, and Narender Kumar
Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G, Susanna Trapp, Nina Derby, Rachel Singer, Andrew Shaw, Vennansha G. Williams, Stuart G. Turville, Julian W. Bess Jr., Jeffrey D. Lifson, and Melissa Robbiani
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier, Linlin Su, C. Yan Cheng, and Dolores D. Mruk
Effectiveness of medical abortion with mifepristone and buccal misoprostol through 59 gestational days, Mary Fjerstad, Irving Sivin, E. Steve Lichtenberg, James Trussell, Kelly Cleland, and Vanessa Cullins
Effect of sexual intercourse on the absorption of levonorgestrel after vaginal administration of 0.75 mg in Carraguard® gel: A randomized, cross-over, pharmacokinetic study, Vivian Brache, Horacio B. Croxatto, Narender Kumar, Régine Sitruk-Ware, Leila Cochón, Veronica Schiappacasse, Irving Sivin, Carla Muñoz, Robin A. Maguire, and Anibal Faundes
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium, Pearl P.Y. Lie, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Extracellular matrix and its role in spermatogenesis, Michelle K.Y. Siu and C. Yan Cheng
Focal adhesion kinase is a blood-testis barrier regulator, Erica R. Siu, Elissa W.P. Wong, Dolores D. Mruk, Catarina S. Porto, and C. Yan Cheng
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B, Han Lin, Guo-Xin Hu, Lei Dong, Qiang Dong, Motoko Mukai, Bing-Bing Chen, Denise R. Holsberger, Chantal M. Sottas, Paul S. Cooke, Qing-Quan Lian, Xiao-Kun Li, and Renshan Ge
In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats, Han Lin, Qing-Quan Lian, Guo-Xin Hu, Yuan Jin, Yunhui Zhang, Dianne O. Hardy, Guo-Rong Chen, Zhong-Qiu Lu, Chantal M. Sottas, Matthew P. Hardy, and Renshan Ge
Leydig cells: From stem cells to aging, Haolin Chen, Renshan Ge, and Barry R. Zirkin
Meta-analysis of 200 or 600 mg mifepristone in association with two prostaglandins for termination of early pregnancy, Michel Lièvre and Régine Sitruk-Ware
Methods for female contraception: A model for innovation in drug delivery systems, Ruth Merkatz, Barbara A. Tokay, and Régine Sitruk-Ware
Mitogen-activated protein kinases in male reproductive function, Michelle W.M. Li, Dolores D. Mruk, and C. Yan Cheng
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11β-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells, Dun Hong, Xing-Wang Li, Qing-Quan Lian, Pankaj Lamba, Daniel J. Bernard, Dianne O. Hardy, Hai-Xiao Chen, and Renshan Ge
Nitric oxide and cyclic nucleotides: Their roles in junction dynamics and spermatogenesis, Nikki P.Y. Lee and C. Yan Cheng
Normal responses to restraint stress in mice lacking the gene for neuronal nitric oxide synthase, Ben-Avi Weissman, Chantal M. Sottas, Michael Holmes, Ping Zhou, Costantino Iadecola, Dianne O. Hardy, Renshan Ge, and Matthew P. Hardy
Novel non-oral hormonal contraceptive methods for women, Anita Nath and Régine Sitruk-Ware
Parenteral administration of progestins for hormonal replacement therapy, Anita Nath and Régine Sitruk-Ware
Peptidergic not monoaminergic fibers profusely innervate the young adult human testis, Yong-Guang Gong, Ming-Ming Feng, Xiang-Nong Hu, Yi-Qiu Wang, Min Gu, Wei Zhang, and Renshan Ge
Pharmacology and clinical applications of selective estrogen receptor modulators, Anita Nath and Régine Sitruk-Ware
Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence, Guo-Xin Hu, Qing-Quan Lian, Renshan Ge, Dianne O. Hardy, and Xiao-Kun Li