The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide. CBR is located at Rockefeller University in New York City.

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Submissions from 2004

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Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: Is this a potential target for male contraceptive development?, Nikki P.Y. Lee and C. Yan Cheng

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Effect of chenodeoxycholic acid on 11β-hydroxysteroid dehydrogenase in various target tissues, David J. Morris, Graham W. Souness, Syed A. Latif, Matthew P. Hardy, and Andrew S. Brem

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Exogenous progestagens and the human breast, Régine Sitruk-Ware and Genevieve Plu-Bureau

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Extracellular matrix: Recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis, Michelle K.Y. Siu and C. Yan Cheng

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Future developments in hormonal contraception, Elof D.B. Johansson

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Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells, Stuart G. Turville, John J. Santos, Ines Frank, Paul U. Cameron, John Wilkinson, Monica Miranda-Saksena, Joanne Dable, Hella Stoessel, Nikolaus Romani, Michael Piatak Jr., Jeffrey D. Lifson, Melissa Robbiani, and Anthony L. Cunningham

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Induction of neutralising antibodies restricts the use of human granulocyte/macrophage colony stimulating factor for vaccine studies in rhesus macaques, Martin Eisenblätter, Christiane Stahl-Hennig, Seraphin Kuate, Nicole Stolte, Edith Jasny, Helmut Hahn, Melissa Robbiani, Klara Tenner-Racz, Paul Racz, Ralph M. Steinman, Klaus Uberla, and Ralf Ignatius

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Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells, Benson T. Akingbemi, Chantal M. Sottas, Anna I. Koulova, Gary R. Klinefelter, and Matthew P. Hardy

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Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis, Michelle K.Y. Siu and C. Yan Cheng

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Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs, David M. Phillips, Kristin M. Sudol, Clark L. Taylor, Laura Guichard, Robert Elsen, and Robin A. Maguire

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Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo, Loreley Villamide-Herrera, Ralf Ignatius, Michael A. Eller, Kelly Wilkinson, Catherine Griffin, Erin Mehlhop, Jennifer Jones, Seol-Young Han, Mark G. Lewis, Stephanie Parrish, Tom C. VanCott, Jeffrey D. Lifson, Sarah Schlesinger, John R. Mascola, and Melissa Robbiani

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Mifepristone does not induce cervical softening in non-pregnant women, Avraham Ben-Chetrit, Talia Eldar-Geva, Tzina Lindenberg, Morshed Farhat, Shlomo Shimonovitz, David Zacut, Hadassa Gelber, Régine Sitruk-Ware, and Irving M. Spitz

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Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation, Antonio Salva, Matthew P. Hardy, Xiu-feng Wu, Chantal M. Sottas, David T. MacLaughlin, Patricia K. Donahoe, and Mary M. Lee

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New delivery systems in contraception: Vaginal rings, Elof D.B. Johansson and Régine Sitruk-Ware

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New progestogens: A review of their effects in perimenopausal and postmenopausal women, Régine Sitruk-Ware

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Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics, Nikki P.Y. Lee and C. Yan Cheng

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Pharmacological profile of progestins, Régine Sitruk-Ware

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Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances, Benson T. Akingbemi, Renshan Ge, Gary R. Klinefelter, and Matthew P. Hardy

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Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress, Qiang Dong, Antonio Salva, Chantal M. Sottas, Enmei Niu, Michael Holmes, and Matthew P. Hardy

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Regulation of blood-testis barrier dynamics: An in vivo study, Ching-hang Wong, Dolores D. Mruk, Wing-Yee Lui, and C. Yan Cheng

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Relative safety of sexual lubricants for rectal intercourse, Kristin M. Sudol and David M. Phillips

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Release-modulating factors strongly affecting steroid diffusion from silicone elastomer, Harold A. Nash, Dale N. Robertson, and Simone J. Evans

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Sertoli-sertoli and sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis, Dolores D. Mruk and C. Yan Cheng

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Short-term Flt3L treatment effectively mobilizes functional macaque dendritic cells, Natalia Teleshova, Jennifer Jones, Jessica Kenney, Jeanette Purcell, Rudolf Bohm, Agegnehu Gettie, and Melissa Robbiani

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Two-year performance of a Nestorone®-releasing contraceptive implant: A three-center study of 300 women, Irving Sivin, Horacio B. Croxatto, Luis Bahamondes, Vivian Brache, Francisco Alvarez-Sanchez, Rebeca Massai, Janet Schechter, Sirpa Ranta, Narender Kumar, Esther Wu, Ana-Sofia Tejeda, Veronica Reyes, Elaine Travers, Arthur Allen, and Alfred J. Moo-Young

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Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis, Nikki P.Y. Lee, Dolores D. Mruk, Anne M. Conway, and C. Yan Cheng

Submissions from 2003

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A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men, Sigrid von Eckardstein, Gabriela Noe, Vivian Brache, Eberhard Nieschlag, Horacio B. Croxatto, Francisco Alvarez-Sanchez, Alfred J. Moo-Young, Irving Sivin, Narender Kumar, Margaret Small, and Kalyan Sundaram

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Adherens junction dynamics in the testis and spermatogenesis, Wing-Yee Lui, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Adhering junction dynamics in the testis are regulated by an interplay of β1-integrin and focal adhesion complex-associated proteins, Michelle K.Y. Siu, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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A role for kit receptor signaling in Leydig cell steroidogenesis, Gerson Rothschild, Chantal M. Sottas, Holger Kissel, Valter Agosti, Katia Manova, Matthew P. Hardy, and Peter Besmer

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Carrageenan formulation prevents macrophage trafficking from vagina: Implications for microbicide development, Maria-Elisa Perotti, Alessia Pirovano, and David M. Phillips

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Dendritic cells as a conduit to improve HIV vaccines, Melissa Robbiani

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Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells, Gui-Min Wang, Peter J. O'Shaughnessy, Curtis Chubb, Bernard Robaire, and Matthew P. Hardy

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Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis, Jovelle B. Laoag-Fernandez, Takeshi Maruo, Paivi Pakarinen, Irving M. Spitz, and Elof D.B. Johansson

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Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types, Thomas J. Ketas, Per Johan Klasse, Catherine Spenlehauer, Mirjana Nesin, Ines Frank, Melissa Robbiani, Julie M. Strizki, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore

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Estradiol-progesterone interaction during the preparation of vaginal rings, Saleh I. Saleh, Sayed H. Khidr, Sayed M. Ahmed, Theodore M. Jackanicz, and Harold A. Nash

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Estradiol/progesterone-releasing vaginal rings for hormone replacement therapy in postmenopausal women, Anna Lissa Hamada, Takeshi Maruo, Takashi Samoto, Shigeki Yoshida, Harold A. Nash, Irving M. Spitz, and Elof D.B. Johansson

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Estrogen receptor-α gene deficiency enhances androgen biosynthesis in the mouse Leydig cell, Benson T. Akingbemi, Renshan Ge, Cheryl S. Rosenfeld, Leslie G. Newton, Dianne O. Hardy, James F. Catterall, Dennis B. Lubahn, Kenneth S. Korach, and Matthew P. Hardy

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Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men, Richard A. Anderson, A. Michael Wallace, Naveed Sattar, Narendar Kumar, and Kalyan Sundaram

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Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study, Yong-Mei Chen, Nikki P.Y. Lee, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Gestational exposure to ethane dimethanesulfonate permanently alters reproductive competence in the CD-1 mouse, Dana K. Tarka-Leeds, Juan D. Suarez, Naomi L. Roberts, John M. Rogers, Matthew P. Hardy, and Gary R. Klinefelter

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Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ cells: Implications for mechanisms of sexual transmission, Zhiwei Wu, Zhiwei Chen, and David M. Phillips

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Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells, Thomas J. Ketas, Ines Frank, Per Johan Klasse, Brian M. Sullivan, Jason P. Gardner, Catherine Spenlehauer, Mirjana Nesin, William C. Olson, John P. Moore, and Melissa Robbiani

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Immunodeficiency virus exploitation of dendritic cells in the early steps of infection, Natalia Teleshova, Ines Frank, and Melissa Robbiani

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Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?, Nikki P.Y. Lee, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Mechanisms of glucocorticoid-induced Leydig cell apoptosis, Hui-Bao Gao, Ming-Han Tong, Yan-Qin Hu, Hai-Yan You, Qiang-Su Guo, Renshan Ge, and Matthew P. Hardy

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Nestorone®: Clinical applications for contraception and HRT, Régine Sitruk-Ware, Margaret Small, Narender Kumar, Yun-yen Tsong, Kalyan Sundaram, and Theodore M. Jackanicz

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Normal reproductive function in InhBP/p120-deficient mice, Daniel J. Bernard, Kathleen H. Burns, Bisong Haupt, Martin M. Matzuk, and Teresa K. Woodruff

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Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies, Régine Sitruk-Ware and Irving M. Spitz

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Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses, Ines Frank, John J. Santos, Erin Mehlhop, Loreley Villamide-Herrera, Christine Santisteban, Agegnehu Gettie, Ralf Ignatius, Jeffrey D. Lifson, and Melissa Robbiani

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Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120, Ronald S. Veazey, Robin J. Shattock, Melissa Robbiani, J. Christian Kirijan, Jennifer Jones, Qinxue Hu, Thomas J. Ketas, Preston A. Marx, Per Johan Klasse, Dennis R. Burton, and John P. Moore

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Progestins in hormonal therapy (HT) today, tomorrow and the next day: A roundtable discussion, Régine Sitruk-Ware

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Prostaglandin (PG) FP and EP1 receptors mediate PGF and PGE2 regulation of interleukin-1β expression in Leydig cell progenitors, Laurence Walch, Emanuela Clavarino, and Patricia L. Morris

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Rab8B GTPase and junction dynamics in the testis, Ann S.N. Lau and Dolores D. Mruk

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Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3′,5′-cyclic guanosine monophosphate/protein kinase G signaling pathway: An in vitro study, Nikki P.Y. Lee and C. Yan Cheng

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Rho GTPases and spermatogenesis, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Risks and benefits, advantages and disadvantages of levonorgestrel-releasing contraceptive implants, Irving Sivin

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Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis, Dolores D. Mruk, Michelle K.Y. Siu, Anne M. Conway, Nikki P.Y. Lee, Ann S.N. Lau, and C. Yan Cheng

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Sertoli cell tight junction dynamics: Their regulation during spermatogenesis, Wing-Yee Lui, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Subdermal progestin implant (Nestorone®) in the treatment of endometriosis: Clinical response to various doses, Kaija Ylänen, Timo Laatikainen, Pekka Lähteenmäki, and Alfred J. Moo-Young

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TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study, Wing-Yee Lui, Daria C.H. Wong, Dolores D. Mruk, and C. Yan Cheng

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TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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The functional roles of 11β-HSD1: Vascular tissue, testis and brain, David J. Morris, Andrew S. Brem, Renshan Ge, P. Harry Jellinck, Randall R. Sakai, and Matthew P. Hardy

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The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates sertoli cell-tight junction dynamics in the rat testis, Michelle K.Y. Siu, Will M. Lee, and C. Yan Cheng

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Transforming growth factor β3 regulates the dynamics of sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Transmission, acute HIV-1 infection and the quest for strategies to prevent infection, Melissa Robbiani and Ashley T. Haase

Submissions from 2002

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Jadelle® levonorgestrel rod implants: A summary of scientific data and lessons learned from programmatic experience, Irving Sivin, Harold A. Nash, and Sandra N. Waldman

Submissions from 1998

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Patent: Male contraceptive implant, Alfred J. Moo-Young and Saleh I. Saleh

Submissions from 1992

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The Copper T 380 Intrauterine Device: A Summary of Scientific Data, Irving Sivin, Forrest Greenslade, Frederick H. Schmidt, and Sandra N. Waldman

Submissions from 1981

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Patent: Intravaginal ring, Harold A. Nash and Daniel R. Mishell Jr.