The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide. CBR is located at Rockefeller University in New York City.

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Submissions from 2011

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Actin binding proteins and spermiogenesis: Some unexpected findings, C. Yan Cheng and Dolores D. Mruk

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Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes, Ka-Wai Mok, Dolores D. Mruk, Pearl P.Y. Lie, Wing Yee Lui, and C. Yan Cheng

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Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, Dolores D. Mruk, and Bruno Silvestrini

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An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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An in vitro system to study sertoli cell blood-testis barrier dynamics, Dolores D. Mruk and C. Yan Cheng

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A study to assess the assembly of a functional blood–testis barrier in developing rat testes, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection, Ines Frank and Melissa Robbiani

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Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis, Yan Ho Cheng, Elissa W.P. Wong, and C. Yan Cheng

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Characterization and functionality of proliferative human sertoli cells, Kitty Chui, Alpa Trivedi, C. Yan Cheng, Diana B. Cherbavaz, Paul F. Dazin, Ai Lam Thu Huynh, James B. Mitchell, Gabriel A. Rabinovich, Linda J. Noble-Haeusslein, and Constance M. John

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c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes, Xiang Xiao, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Desmosomes in the testis: Moving into an unchartered territory, Dolores D. Mruk and C. Yan Cheng

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Differential nuclear receptor and gene expression in human endometrial adenocarcinoma cells: Regulation by a novel selective progesterone receptor modulator, KeumSil Hwang, Lyann Mitchell, Catherine Rapelje, and Patricia L. Morris

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Drug transporters and blood–testis barrier function, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Drug transporters, the blood–testis barrier, and spermatogenesis, Linlin Su, Dolores D. Mruk, and C. Yan Cheng

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Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes, Guo-Xin Hu, Binghai Zhao, Yanhui Chu, X.H. Li, Benson T. Akingbemi, Zhi-Qiang Zheng, and Renshan Ge

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Emerging role for drug transporters at the blood-testis barrier, Dolores D. Mruk, Linlin Su, and C. Yan Cheng

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Enhanced chemiluminescence (ECL) for routine immunoblotting. An inexpensive alternative to commercially available kits, Dolores D. Mruk and C. Yan Cheng

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Environmental contaminants: Is male reproductive health at risk?, Dolores D. Mruk and C. Yan Cheng

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Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2, Xue Ma, Qing-Quan Lian, Qiang Dong, and Renshan Ge

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Environmental toxicants and male reproductive function, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Linlin Su, Erica R. Siu, Helen H.N. Yan, J. Mannu, Premendu P. Mathur, Michele Bonanomi, Bruno Silvestrini, and Dolores D. Mruk

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Hormonal influences in multiple sclerosis: New therapeutic benefits for steroids, Martine El-Etr, Abdel M. Ghoumari, Régine Sitruk-Ware, and Michael Schumacher

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HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target, Elena Martinelli, Hugo Tharinger, Ines Frank, James Arthos, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, and Melissa Robbiani

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Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro, Othell Begay, Ninochka Jean-Pierre, Ciby J. Abraham, Anne Chudolij, Samantha Seidor, Aixa Rodriguez, Brian E. Ford, Marcus Henderson, David Katz, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero

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Impacts of environmental toxicants on male reproductive dysfunction, Elissa W.P. Wong and C. Yan Cheng

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Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood–testis-barrier-hemidesmosome functional axis in the testis, C. Yan Cheng, Pearl P.Y. Lie, Ka-Wai Mok, Yan Ho Cheng, Elissa W.P. Wong, Jayakanthan Mannu, Premendu P. Mathur, Helen H.N. Yan, and Dolores D. Mruk

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Interleukin-1α is a regulator of the blood-testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk

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Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas, Takeshi Maruo, Noriyuki Ohara, Shigeki Yoshida, Koji Nakabayashi, Hiroko Sasaki, Qin Xu, Hiroya Matsuo, Régine Sitruk-Ware, and Hideto Yamada

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Male contraception: Where do we go from here?, C. Yan Cheng and Dolores D. Mruk

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Metabolic effects of contraceptive steroids, Régine Sitruk-Ware and Anita Nath

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Myeloid dendritic cells in HIV-1 infection, Nina Derby, Elena Martinelli, and Melissa Robbiani

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Nomegestrol acetate, a novel progestogen for oral contraception, Alfred O. Mueck and Régine Sitruk-Ware

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P-glycoprotein regulates blood–testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK), Linlin Su, Dolores D. Mruk, Wing Yee Lui, Will M. Lee, and C. Yan Chen

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Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Xiang Xiao, Michelle W.M. Li, Wing Yee Lui, and Will M. Lee

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Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors, Rashad Hussain, Martine El-Etr, Ouardia Gaci, Jennifer Rakotomamonjy, Wendy B. Macklin, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, and Abdel M. Ghoumari

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Regulation of blood–testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Dolores D. Mruk, Helen H.N. Yan, Ka-Wai Mok, Jayakanthan Mannu, Premendu P. Mathur, Wing-Yee Lui, Will M. Lee, Michele Bonanomi, and Bruno Silvestrini

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Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3, C. Yan Cheng and Dolores D. Mruk

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Role of 11β-OH-C_19 and C_21 steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells, Syed A. Latif, Mae Shen, Renshan Ge, Chantal M. Sottas, Matthew P. Hardy, and David J. Morris

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Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids, Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, and Peter D. Sun

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Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis, Dolores D. Mruk and C. Yan Cheng

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The biology of the desmosome-like junction: A versatile anchoring junction and signal transducer in the seminiferous epithelium, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk

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The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances, Binghai Zhao, Qing-Quan Lian, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge

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The myotubularin family of lipid phosphatases in disease and in spermatogenesis, Dolores D. Mruk and C. Yan Cheng

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The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques, Rachel Singer, Nina Derby, Aixa Rodriguez, Larisa Kizima, Jessica Kenney, Meropi Aravantinou, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes, Michelle K.Y. Siu, Ching-hang Wong, Weiliang Xia, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Validation of a dye stain assay for vaginally inserted hydroxyethylcellulose-filled microbicide applicators, Lauren L. Katzen, José Fernández-Romero, Avina Sarna, Kailapuri G. Murugavel, Daniel Gawarecki, Thomas Zydowsky, and Barbara Mensch

Submissions from 2010

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7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat leydig cells, Guo-Xin Hu, Qing-Quan Lian, Bing-Bing Chen, Pramod Vishwanath Prasad, Narender Kumar, Zhi-Qiang Zheng, and Renshan Ge

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Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo, Linlin Su, C. Yan Cheng, and Dolores D. Mruk

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A local autocrine axis in the testes that regulates spermatogenesis, C. Yan Cheng and Dolores D. Mruk

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A tonsillar polyICLC/At-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation, Panagiotis Vagenas, Meropi Aravantinou, Vennansha G. Williams, Edith Jasny, Michael Piatak Jr., Jeffrey D. Lifson, Andres M. Salazar, James Blanchard, Agegnehu Gettie, and Melissa Robbiani

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Claudin and occludin expression and function in the seminiferous epithelium, Carla M.K. Morrow, Dolores D. Mruk, C. Yan Cheng, and R. A. Hess

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Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo, Lifei Liu, Liqin Zhao, Hongyun She, Shuhua Chen, Jun Ming Wang, Charisse Wong, Kelsey McClure, Régine Sitruk-Ware, and Roberta Diaz Brinton

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Connexin 43 is critical to maintain the homeostasis of the blood–testis barrier via its effects on tight junction reassembly, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3, Guo-Xin Hu, Guang Liang, Yanhui Chu, Xiao-Kun Li, Qing-Quan Lian, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, and Renshan Ge

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Cytoskeletal dynamics and spermatogenesis, Pearl P.Y. Lie, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Deletion of the Igf1 gene: Suppressive effects on adult Leydig cell development, Guo-Xin Hu, Han Lin, Guo-Rong Chen, Bing-Bing Chen, Qing-Quan Lian, Dianne O. Hardy, Barry R. Zirkin, and Renshan Ge

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Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood–testis barrier, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women, Gabriela Noe; Régine Sitruk-Ware; Fernando Zegers-Hochschild; Bruce Variano; Juan Carlos Montero; P. Arriagada; A. Li; Frank Z. Stanczyk; J.C. Felix; Daniel R. Mishell, Jr.; and Horacio B. Croxatto

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Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells, Ye-Chen Xiao, Ya-Dong Huang, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge

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Inhibition of 3β- and 17β-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid, Binghai Zhao, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge

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Inhibition of LH-stimulated androgen production in rat immature Leydig cells: Effects on nuclear receptor steroidogenic factor 1 by FGF2, Ye-Chen Xiao, Dianne O. Hardy, Chantal M. Sottas, Xiao-Kun Li, and Renshan Ge

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Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques, Robert M. Brenner, Ov D. Slayden, Anita Nath, Yun-yen Tsong, and Régine Sitruk-Ware

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In vivo binding and retention of CD4-Specific DARPin 57.2 in macaques, Pavel Pugach, Anders Krarup, Agegnehu Gettie, Marcelo Kuroda, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Alexandra Trkola, and Melissa Robbiani

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New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk

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New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk

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No-needle local anesthesia for adult male circumcision, Yifeng Peng, Puneet Masson, Philip S. Li, Yue Chang, Long Tian, Richard Lee, Howard H. Kim, David C. Sokal, and Marc Goldstein

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Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats, Shang-Qin Chen, Jin-Ni Chen, Xiao-Hong Cai, Guo-Rong Chen, Yuan Gao, Renshan Ge, Hai-Shan Wu, Zhen-Lang Lin, and Jing Lin

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Progesterone vaginal ring for contraceptive use during lactation, Anita Nath and Régine Sitruk-Ware

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Regulation of blood–testis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event, Elissa W.P. Wong, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances, C. Yan Cheng, Elissa W.P. Wong, Helen H.N. Yan, and Dolores D. Mruk

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Restricted Arp3 expression in the testis prevents blood–testis barrier disruption during junction restructuring at spermatogenesis, Pearl P.Y. Lie, Apple Y.N. Chan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Sertoli-germ cell junctions in the testis: A review of recent data, Ilona A. Ropera, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk

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Single-dose Pharmacokinetics of Nestorone®, a potential female-contraceptive, Pramod Vishwanath Prasad, Mohammad Bashir, Régine Sitruk-Ware, and Narender Kumar

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State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices, Irving Sivin and I. Batar

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State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices, Irving Sivin and I. Batar

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State-of-the-art of non-hormonal methods of contraception: I. Mechanical barrier contraception, I. Batar and Irving Sivin

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State-of-the-art of non-hormonal methods of contraception: I. Mechanical barrier contraception, I. Batar and Irving Sivin

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State-of-the-art of non-hormonal methods of contraception: IV. Natural family planning, G. Freundl, Irving Sivin, and I. Batar

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State-of-the-art of non-hormonal methods of contraception: IV. Natural family planning, G. Freundl, Irving Sivin, and I. Batar

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Structure-dependent inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 activities by phthalates, Binghai Zhao, Yanhui Chu, Ya-Dong Huang, Dianne O. Hardy, Shaoqiang Lin, and Renshan Ge

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The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis, Susanna Kwitny, Angela V. Klaus, and Gary R. Hunnicutt

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The biology of spermatogenesis: The past, present and future, C. Yan Cheng and Dolores D. Mruk

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The use of newer progestins for contraception, Régine Sitruk-Ware and Anita Nath

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The use of newer progestins for contraception, Régine Sitruk-Ware and Anita Nath

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Tight junctions in the testis: New perspectives, Dolores D. Mruk and C. Y. Cheng

Submissions from 2009

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14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis, Shengyi Sun, Elissa W.P. Wong, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng

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14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes, Elissa W.P. Wong, Shengyi Sun, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng

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Acceptability of a Carrageenan-based candidate vaginal microbicide and matching placebo: Findings from a Phase II safety trial among women in Chiang Rai, Thailand, Heidi E. Jones, Supaporn Chaikummao, Janneke van de Wijgert, Barbara Friedland, Chomnad Manopaiboon, Paisit Witwatwongwana, Mayuree Wankrairot, Nartlada Chantharojwong, and Peter H. Kilmarx

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Activins regulate 17β-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells, Beata Bak, Laura Carpio, Jinjing L. Kipp, Pankaj Lamba, Ying Wang, Renshan Ge, Matthew P. Hardy, Kelly E. Mayo, and Daniel J. Bernard

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A decision analysis of treatments for nonobstructive azoospermia associated with varicocele, Richard Lee, Philip S. Li, Marc Goldstein, Glenn Schattman, and Peter N. Schlegel

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Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study, Guo-Xin Hu, Lu-Feng Hu, Dai-Zheng Yang, Jun-Wei Li, Guo-Rong Chen, Bing-Bing Chen, Dolores D. Mruk, Michele Bonanomi, Bruno Silvestrini, C. Yan Cheng, and Renshan Ge

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A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy, Federica Crostarosa, Meropi Aravantinou, Onome J. Akpogheneta, Edith Jasny, Andrew Shaw, Jessica Kenney, Michael Piatak Jr., Jeffrey D. Lifson, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Thomas M. Zydowsky, James Blanchard, Agegnehu Gettie, and Melissa Robbiani

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An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective, C. Yan Cheng and Dolores D. Mruk

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An in vivo study on adjudin and blood-testis barrier dynamics, Ilona A. Kopera, Linlin Su, Barbara Bilínska, C. Yan Cheng, and Dolores D. Mruk

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An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model, Erica R. Siu, Elissa W.P. Wong, Dolores D. Mruk, K.L. Sze, Catarina S. Porto, and C. Yan Cheng

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Cadmium-induced testicular injury, Erica R. Siu, Dolores D. Mruk, Catarina S. Porto, and C. Yan Cheng

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Central modifications of allopregnanolone and β-endorphin following subcutaneous administration of Nestorone, E. Lenzi, N. Pluchino, S. Begliuomini, E. Casarosa, S. Merlini, A. Giannini, M. Luisi, Narender Kumar, Régine Sitruk-Ware, and A.R. Genazzani

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Characterization of a novel gain of function glucocorticoid receptor knock-in mouse, Junhui Zhang, Renshan Ge, Catherine Matte-Martone, Julie Goodwin, Warren D. Shlomchik, Mark J. Mamula, Ali Kooshkabadi, Matthew P. Hardy, and David Geller

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Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men, Vahid Mahabadi, John K. Amory, Ronald S. Swerdloff, William J. Bremner, Stephanie T. Page, Régine Sitruk-Ware, Peter D. Christensen, Narender Kumar, Yun-yen Tsong, Diana Blithe, and Christina Wang

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Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Coordinating cellular events during spermatogenesis: A biochemical model, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk