The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide.
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Submissions from 2012
Effects of a novel estrogen-free, progesterone receptor modulator-contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women, Vivian Brache; Régine Sitruk-Ware; A. Williams; Diana Blithe; Horacio B. Croxatto; Narender Kumar; Sushma Kumar; Yun-yen Tsong; Irving Sivin; Anita Nath; Heather Sussman; Leila Cochon; Marie-José Miranda; Veronica Reyes; Anibal Faundes; and Daniel R. Mishell, Jr.
Filamin A: A regulator of blood-testis barrier assembly during post-natal development, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis, Wenhui Su, Dolores D. Mruk, Pearl P.Y. Lie, Wing-Yee Lui, and C. Yan Cheng
Focal adhesion kinase-Tyr^407 and -Tyr^397 exhibit antagonistic effects on blood–testis barrier dynamics in the rat, Pearl P.Y. Lie, Dolores D. Mruk, Ka-Wai Mok, Linlin Su, Will M. Lee, and C. Yan Cheng
Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein, Mandana Rad, Jacobus Burggraaf, Régine Sitruk-Ware, Marieke L. de Kam, Adam F. Cohen, and Cornelius Kluft
In search of suitable in vitro models to study germ cell movement across the blood-testis barrier, Dolores D. Mruk and C. Yan Cheng
Intercellular adhesion molecule-1 is a regulator of blood-testis barrier function, Xiang Xiao, C. Yan Cheng, and Dolores D. Mruk
Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis, Elizabeth I. Tang, Xiang Xiao, Dolores D. Mruk, Xiao-jing Qian, Ka-Wai Mok, Pranitha Jenardhanan, Will M. Lee, Premendu P. Mathur, and C. Yan Cheng
Non-specific microbicide development: Then and now, Joseph W. Romano, Melissa Robbiani, Gustavo F. Doncel, and Thomas Moench
Patent: Methods and compositions for emergency contraception using endothelin receptor antagonists, Indrani C. Bagchi and Régine Sitruk-Ware
Postpartum unintended pregnancy and contraception practice among rural-to-urban migrant women in Shanghai, Yong-mei Huang, Ruth Merkatz, Jian-Zhong Kang, Kevin Roberts, Xiao-Yu Hu, Francis Di Donato, Régine Sitruk-Ware, and Li-nan Cheng
Progesterone receptors: A key for neuroprotection in experimental stroke, Ailing Liu, Isabelle Margaill, Shaodong Zhang, Florencia Labombarda, Berard Coqueran, Brigitte Delespierre, Philippe Liere, Catherine Marchand-Leroux, Bert W. O'Malley, John P. Lydon, Alejandro De Nicola, Régine Sitruk-Ware, Claudia Mattern, Michel Plotkine, Michael Schumacher, and Rachida Guennoun
Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
rpS6 regulates blood–testis barrier dynamics by affecting F-actin organization and protein recruitment, Ka-Wai Mok, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
The blood–testis barrier and its implications for male contraception, C. Yan Cheng and Dolores D. Mruk
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection, Meropi Aravantinou, Rachel Singer, Nina Derby, Giulia Calenda, Paul Mawson, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Guillermo Villegas, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, Natalia Teleshova, and Melissa Robbiani
The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood–testis barrier dynamics and spermatid polarity during spermatogenesis, Wenhui Su, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton, Marta Lydka, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk
Vasectomy reversal in humans, Aaron M. Bernie, E. Charles Osterberg, Peter J. Stahl, Ranjith Ramasamy, and Marc Goldstein
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high dose HSV-2 vaginal and rectal challenge, José Fernández-Romero, Ciby J. Abraham, Aixa Rodriguez, Larisa Kizima, Ninochka Jean-Pierre, Radhika Menon, Othell Begay, Samantha Seidor, Brian E. Ford, Pedro I. Gil, Jennifer Peters, David Katz, Melissa Robbiani, and Thomas Zydowsky
Submissions from 2011
7 α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: A preclinical study in the aged male orchidectomized rat model, M. Sinnesael, F. Callewaert, M. Morreels, Narender Kumar, Régine Sitruk-Ware, K. van Proeyen, P. Hespel, Steven Boonen, F. Claessens, and Dirk Vanderschueren
Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis, Michelle W.M. Li, Xiang Xiao, Dolores D. Mruk, Yee-ling Lam, Will M. Lee, Wing-Yee Lui, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng
Actin binding proteins and spermiogenesis: Some unexpected findings, C. Yan Cheng and Dolores D. Mruk
Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes, Ka-Wai Mok, Dolores D. Mruk, Pearl P.Y. Lie, Wing Yee Lui, and C. Yan Cheng
Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, Dolores D. Mruk, and Bruno Silvestrini
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
An in vitro system to study sertoli cell blood-testis barrier dynamics, Dolores D. Mruk and C. Yan Cheng
A study to assess the assembly of a functional blood–testis barrier in developing rat testes, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection, Ines Frank and Melissa Robbiani
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis, Yan Ho Cheng, Elissa W.P. Wong, and C. Yan Cheng
Characterization and functionality of proliferative human sertoli cells, Kitty Chui, Alpa Trivedi, C. Yan Cheng, Diana B. Cherbavaz, Paul F. Dazin, Ai Lam Thu Huynh, James B. Mitchell, Gabriel A. Rabinovich, Linda J. Noble-Haeusslein, and Constance M. John
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes, Xiang Xiao, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Desmosomes in the testis: Moving into an unchartered territory, Dolores D. Mruk and C. Yan Cheng
Differential nuclear receptor and gene expression in human endometrial adenocarcinoma cells: Regulation by a novel selective progesterone receptor modulator, KeumSil Hwang, Lyann Mitchell, Catherine Rapelje, and Patricia L. Morris
Drug transporters and blood–testis barrier function, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Drug transporters, the blood–testis barrier, and spermatogenesis, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes, Guo-Xin Hu, Binghai Zhao, Yanhui Chu, X.H. Li, Benson T. Akingbemi, Zhi-Qiang Zheng, and Renshan Ge
Emerging role for drug transporters at the blood-testis barrier, Dolores D. Mruk, Linlin Su, and C. Yan Cheng
Enhanced chemiluminescence (ECL) for routine immunoblotting. An inexpensive alternative to commercially available kits, Dolores D. Mruk and C. Yan Cheng
Environmental contaminants: Is male reproductive health at risk?, Dolores D. Mruk and C. Yan Cheng
Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2, Xue Ma, Qing-Quan Lian, Qiang Dong, and Renshan Ge
Environmental toxicants and male reproductive function, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Linlin Su, Erica R. Siu, Helen H.N. Yan, J. Mannu, Premendu P. Mathur, Michele Bonanomi, Bruno Silvestrini, and Dolores D. Mruk
Hormonal influences in multiple sclerosis: New therapeutic benefits for steroids, Martine El-Etr, Abdel M. Ghoumari, Régine Sitruk-Ware, and Michael Schumacher
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target, Elena Martinelli, Hugo Tharinger, Ines Frank, James Arthos, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro, Othell Begay, Ninochka Jean-Pierre, Ciby J. Abraham, Anne Chudolij, Samantha Seidor, Aixa Rodriguez, Brian E. Ford, Marcus Henderson, David Katz, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
Impacts of environmental toxicants on male reproductive dysfunction, Elissa W.P. Wong and C. Yan Cheng
Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood–testis-barrier-hemidesmosome functional axis in the testis, C. Yan Cheng, Pearl P.Y. Lie, Ka-Wai Mok, Yan Ho Cheng, Elissa W.P. Wong, Jayakanthan Mannu, Premendu P. Mathur, Helen H.N. Yan, and Dolores D. Mruk
Interleukin-1α is a regulator of the blood-testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas, Takeshi Maruo, Noriyuki Ohara, Shigeki Yoshida, Koji Nakabayashi, Hiroko Sasaki, Qin Xu, Hiroya Matsuo, Régine Sitruk-Ware, and Hideto Yamada
Male contraception: Where do we go from here?, C. Yan Cheng and Dolores D. Mruk
Metabolic effects of contraceptive steroids, Régine Sitruk-Ware and Anita Nath
Myeloid dendritic cells in HIV-1 infection, Nina Derby, Elena Martinelli, and Melissa Robbiani
Nomegestrol acetate, a novel progestogen for oral contraception, Alfred O. Mueck and Régine Sitruk-Ware
P-glycoprotein regulates blood–testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK), Linlin Su, Dolores D. Mruk, Wing Yee Lui, Will M. Lee, and C. Yan Chen
Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Xiang Xiao, Michelle W.M. Li, Wing Yee Lui, and Will M. Lee
Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors, Rashad Hussain, Martine El-Etr, Ouardia Gaci, Jennifer Rakotomamonjy, Wendy B. Macklin, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, and Abdel M. Ghoumari
Regulation of blood–testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Dolores D. Mruk, Helen H.N. Yan, Ka-Wai Mok, Jayakanthan Mannu, Premendu P. Mathur, Wing-Yee Lui, Will M. Lee, Michele Bonanomi, and Bruno Silvestrini
Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3, C. Yan Cheng and Dolores D. Mruk
Role of 11β-OH-C_19 and C_21 steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells, Syed A. Latif, Mae Shen, Renshan Ge, Chantal M. Sottas, Matthew P. Hardy, and David J. Morris
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids, Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, and Peter D. Sun
Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis, Dolores D. Mruk and C. Yan Cheng
The biology of the desmosome-like junction: A versatile anchoring junction and signal transducer in the seminiferous epithelium, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances, Binghai Zhao, Qing-Quan Lian, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
The myotubularin family of lipid phosphatases in disease and in spermatogenesis, Dolores D. Mruk and C. Yan Cheng
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques, Rachel Singer, Nina Derby, Aixa Rodriguez, Larisa Kizima, Jessica Kenney, Meropi Aravantinou, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes, Michelle K.Y. Siu, Ching-hang Wong, Weiliang Xia, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Validation of a dye stain assay for vaginally inserted hydroxyethylcellulose-filled microbicide applicators, Lauren L. Katzen, José Fernández-Romero, Avina Sarna, Kailapuri G. Murugavel, Daniel Gawarecki, Thomas Zydowsky, and Barbara Mensch
Submissions from 2010
7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat leydig cells, Guo-Xin Hu, Qing-Quan Lian, Bing-Bing Chen, Pramod Vishwanath Prasad, Narender Kumar, Zhi-Qiang Zheng, and Renshan Ge
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo, Linlin Su, C. Yan Cheng, and Dolores D. Mruk
A local autocrine axis in the testes that regulates spermatogenesis, C. Yan Cheng and Dolores D. Mruk
A tonsillar polyICLC/At-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation, Panagiotis Vagenas, Meropi Aravantinou, Vennansha G. Williams, Edith Jasny, Michael Piatak Jr., Jeffrey D. Lifson, Andres M. Salazar, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Claudin and occludin expression and function in the seminiferous epithelium, Carla M.K. Morrow, Dolores D. Mruk, C. Yan Cheng, and R. A. Hess
Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo, Lifei Liu, Liqin Zhao, Hongyun She, Shuhua Chen, Jun Ming Wang, Charisse Wong, Kelsey McClure, Régine Sitruk-Ware, and Roberta Diaz Brinton
Connexin 43 is critical to maintain the homeostasis of the blood–testis barrier via its effects on tight junction reassembly, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3, Guo-Xin Hu, Guang Liang, Yanhui Chu, Xiao-Kun Li, Qing-Quan Lian, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, and Renshan Ge
Cytoskeletal dynamics and spermatogenesis, Pearl P.Y. Lie, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Deletion of the Igf1 gene: Suppressive effects on adult Leydig cell development, Guo-Xin Hu, Han Lin, Guo-Rong Chen, Bing-Bing Chen, Qing-Quan Lian, Dianne O. Hardy, Barry R. Zirkin, and Renshan Ge
Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood–testis barrier, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women, Gabriela Noe; Régine Sitruk-Ware; Fernando Zegers-Hochschild; Bruce Variano; Juan Carlos Montero; P. Arriagada; A. Li; Frank Z. Stanczyk; J.C. Felix; Daniel R. Mishell, Jr.; and Horacio B. Croxatto
Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells, Ye-Chen Xiao, Ya-Dong Huang, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Inhibition of 3β- and 17β-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid, Binghai Zhao, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Inhibition of LH-stimulated androgen production in rat immature Leydig cells: Effects on nuclear receptor steroidogenic factor 1 by FGF2, Ye-Chen Xiao, Dianne O. Hardy, Chantal M. Sottas, Xiao-Kun Li, and Renshan Ge
Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques, Robert M. Brenner, Ov D. Slayden, Anita Nath, Yun-yen Tsong, and Régine Sitruk-Ware
In vivo binding and retention of CD4-Specific DARPin 57.2 in macaques, Pavel Pugach, Anders Krarup, Agegnehu Gettie, Marcelo Kuroda, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Alexandra Trkola, and Melissa Robbiani
New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk
New frontiers in nonhormonal male contraception, C. Yan Cheng and Dolores D. Mruk
No-needle local anesthesia for adult male circumcision, Yifeng Peng, Puneet Masson, Philip S. Li, Yue Chang, Long Tian, Richard Lee, Howard H. Kim, David C. Sokal, and Marc Goldstein
Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats, Shang-Qin Chen, Jin-Ni Chen, Xiao-Hong Cai, Guo-Rong Chen, Yuan Gao, Renshan Ge, Hai-Shan Wu, Zhen-Lang Lin, and Jing Lin
Progesterone vaginal ring for contraceptive use during lactation, Anita Nath and Régine Sitruk-Ware
Regulation of blood–testis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event, Elissa W.P. Wong, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances, C. Yan Cheng, Elissa W.P. Wong, Helen H.N. Yan, and Dolores D. Mruk
Restricted Arp3 expression in the testis prevents blood–testis barrier disruption during junction restructuring at spermatogenesis, Pearl P.Y. Lie, Apple Y.N. Chan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Sertoli-germ cell junctions in the testis: A review of recent data, Ilona A. Ropera, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk
Single-dose Pharmacokinetics of Nestorone®, a potential female-contraceptive, Pramod Vishwanath Prasad, Mohammad Bashir, Régine Sitruk-Ware, and Narender Kumar
State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices, Irving Sivin and I. Batar
State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices, Irving Sivin and I. Batar
State-of-the-art of non-hormonal methods of contraception: I. Mechanical barrier contraception, I. Batar and Irving Sivin