Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3

Authors

Guo-Xin Hu
Guang Liang
Yanhui Chu
Xiao-Kun Li
Qing-Quan Lian
Han Lin
Yi He
Yadong Huang
Dianne O. Hardy, Population Council
Renshan Ge, Population Council

Document Type

Article (peer-reviewed)

Publication Date

2010

Abstract

Non-steroidal compounds that inhibit 17β-hydroxysteroid dehydrogenase isoform 3 (17β-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17β-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.

Recommended Citation

Hu, Guo-Xin, Guang Liang, Yanhui Chu, Xiao-Kun Li, Qing-Quan Lian, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, and Renshan Ge. 2010. "Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3," Bioorganic and Medicinal Chemistry Letters 20(8): 2549–2551.

DOI

10.1016/j.bmcl.2010.02.089

Language

English