The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide.
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Submissions from 2018
Monitoring the integrity of the blood-testis barrier (BTB): An in vivo assay, Haiqi Chen, Wing-Yee Lui, Dolores D. Mruk, Xiang Xiao, Renshan Ge, Qing-Quan Lian, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng
mTORC1/rpS6 regulates blood-testis barrier (BTB) dynamics and spermatogenetic function in the testis in vivo, Stephen Y.T. Li, Ming Yan, Haiqi Chen, Tito T. Jesus, Will M. Lee, Xiang Xiao, and C. Yan Cheng
Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects, Alejandro De Nicola, Laura Garay, Maria Meyer, Rachida Guennoun, Régine Sitruk-Ware, Michael Schumacher, and Maria Claudia Gonzalez Deniselle
Non-clinical studies of progesterone, Régine Sitruk-Ware
Patent: Combination product for the prevention of sexually transmitted infections, Barry R. O'Keefe, Melissa Robbiani, and José Fernández-Romero
Patent: Neuroprotection and myelin repair using Nestorone®, Régine Sitruk-Ware, Michael Schumacher, Maria Helmut, Roberta Brinton, Martine El-Etr, Abdelmouman Ghoumari, and Rachida Guennoun
Regulation of blood–testis barrier assembly in vivo by germ cells, Xiao-Yu Li, Yan Zhang, Xiu-Xia Wang, Cheng Jin, Yu-Qian Wang, Tie-Cheng Sun, Ji-Xin Tang, Alia Batool, Shou-Long Deng, Su-Ren Chen, C. Yan Cheng, and Yi-Xun Liu
Regulation of blood-testis barrier (BTB) dynamics, role of actin-, and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Nan Li, Dolores D. Mruk, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng
Safety of tubal occlusion by minilaparotomy provided by trained clinical officers versus assistant medical officers in Tanzania: A randomized, controlled, noninferiority trial, Mark Barone, Zuhura Mbuguni, Japhet Ominde Achola, Annette Almeida, Carmela Cordero, Joseph Kanama, Adriana Marquina, Projestine Muganyizi, Jamilla Mwanga, Daniel Ouma, Caitlin S. Shannon, and Leopold Tibyehabwa
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7, Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa Byrareddy, Philip J. Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D. Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A. Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S. Fauci, and James Arthos
Signaling pathways regulating blood-tissue barriers—Lesson from the testis, Qing Wen, Elizabeth I. Tang, Ying Gao, Tito T. Jesus, Darren S. Chu, Will M. Lee, Chris K.C. Wong, Yi-Xun Liu, Xiang Xiao, Bruno Silvestrini, and C. Yan Cheng
Simplifying the ShangRing technique for circumcision in boys and men: Use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment, Mark Barone, Philip S. Li, Richard K. Lee, Daniel Ouma, Millicent Oundo, Mukhaye Barasa, Jairus Oketch, Patrick Otiende, Nixon Nyangweso, Mary N. Maina, Nicholas Kiswi, Betty Chirchir, Marc Goldstein, and Quentin Awori
Solid state ^13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system, Clare F. McCoy, David C. Apperley, Bruce Variano, Heather Sussman, Dan Loeven, Peter Boyd, and R. Karl Malcolm
Study to evaluate the safety of griffithsin in a carrageenan gel in healthy women, Population Council
SUMOylation regulates germinal vesicle break-down and the AKT/PKB pathway during mouse oocyte maturation, Weber Beringui Feitosa and Patricia L. Morris
Therapeutic progestin segesterone acetate promotes neurogenesis: Implications for sustaining regeneration in female brain, Shuhua Chen, Narender Kumar, Zisu Mao, Régine Sitruk-Ware, and Roberta Diaz Brinton
Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: Updated indirect comparison meta-analysis, Agustin Conde-Agudelo, Roberto Romero, Eduardo Da Fonseca, John M. O'Brien, Elcin Cetingoz, George W. Creasy, Sonia S. Hassan, Offer Erez, Percy Pacora, and Kypros H. Nicolaides
Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
Submissions from 2017
Abcb1a and Abcb1b genes function differentially in blood–testis barrier dynamics in the rat, Linlin Su, C. Yan Cheng, Will M. Lee, Min Zhang, Fangfang Yang, Bin Zhao, Daishu Han, Yixun Liu, and Dahai Hu
Adjudin—A male contraceptive with anti-cancer, anti-neuroinflammation and anti-ototoxicity activities, Yan Ho Cheng, Weiliang Xia, Xiang Xiao, Elizabeth I. Tang, Haiqi Chen, Qing Wen, Ying Gao, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
A fresh look at an old problem, Thomas Zydowsky
A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques, Meropi Aravantinou, Ines Frank, Geraldine Arrode-Bruses, Moriah Szpara, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Nina Derby, and Elena Martinelli
An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques, Nina Derby, Meropi Aravantinou, Jessica Kenney, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Olga Mizenina, Keith Levendosky, Michael Cooney, Samantha Seidor, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk
Basement membrane laminin α2 regulates BTB dynamics via its effects on F-actin- and microtubule (MT)-cytoskeletons via mTORC1 signaling, Ying Gao, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
Cell polarity, cell adhesion, and spermatogenesis: Role of cytoskeletons, Linxi Li, Ying Gao, Haiqi Chen, Tito T. Jesus, Elizabeth I. Tang, Nan Li, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng
Drebrin and spermatogenesis, Haiqi Chen, Michelle W.M. Li, and C. Yan Cheng
Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance, Kenneth S.K. Tung, Jessica Harakal, Hui Qiao, Claudia Rival, Jonathan C.H. Li, Alberta G.A. Paul, Karen Wheeler, Patcharin Pramoonjago, Constance M. Grafer, Wei Sun, Robert D. Sampson, Elissa W.P. Wong, Prabhakara P. Reddi, Umesh S. Deshmukh, Daniel M. Hardy, Huanghui Tang, C. Yan Cheng, and Erwin Goldberg
Emerging role for mammalian target of rapamycin in male fertility, Pedro F. Oliveira, C. Yan Cheng, and Marco G. Alves
Experimental oral herpes simplex virus-1 (HSV-1) co-infection in simian immunodeficiency virus (SIV)-infected rhesus macaques, Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, and Nina Derby
Factors predicting improper use of a woman-controlled long-acting reversible contraceptive: Results from the acceptability study of a novel contraceptive vaginal ring, Bianca M. Stifani, Marlena Gehret Plagianos, Carolina Sales Vieira, and Ruth Merkatz
Focal adhesion kinase (FAK), Haiqi Chen and C. Yan Cheng
Human spermatogenesis and its regulation, Haiqi Chen, Dolores D. Mruk, Xiang Xiao, and C. Yan Cheng
Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: A randomized clinical trial, Michael Zitzmann, Julia Rohayem, J. Raidt, Sabine Kliesch, Narender Kumar, and Régine Sitruk-Ware
Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with α-catenin at the blood–testis barrier, Dolores D. Mruk, Michele Bonanomi, and Bruno Silvestrini
Mammalian target of rapamycin (mTOR): A central regulator of male fertility?, Tito T. Jesus, Pedro F. Oliveira, Mario Sousa, C. Yan Cheng, and Marco G. Alves
MAP/Microtubule affinity-regulating kinase, Elizabeth I. Tang and C. Yan Cheng
Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system, Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu
MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1, Olga Mizenina, Mayla Hsu, Ninochka Jean-Pierre, Meropi Aravantinou, Keith Levendosky, Maria Gabriela Paglini, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
MZC gel inhibits SHIV-RT and HSV-2 in macaque vaginal mucosa and SHIV-RT in rectal mucosa, Giulia Calenda, Guillermo Villegas, Patrick Barnable, Claudia Litterst, Keith Levendosky, Agegnehu Gettie, Michael Cooney, James Blanchard, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
Nestorone® (NES) a novel progestin for non-oral contraception: Structure-activity relationships and brain metabolism studies, Narender Kumar, Jerome Fagart, Philippe Liere, Scott J. Mitchell, Alanah R. Knibb, Isabelle Petit-Topin, Marion Rame, Martine El-Etr, Michael Schumacher, Jeremy J. Lambert, Marie-Edith Rafestin-Oblin, and Régine Sitruk-Ware
Patent: Nestorone®/estradiol transdermal gel, Régine Sitruk-Ware, Dario Norberto Ramon Carrara, and Arnaud Grenier
Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2, Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng
Pixuna virus modifies host cell cytoskeleton to secure infection, Pedro Ignacio Gil, Guillermo Albrieu-Llinás, Estela Cecilia Mlewski, Marina Monetti, Laura Fozzatti, Cecilia Cuffini, José Fernández-Romero, Patricia Kunda, and Maria Gabriela Paglini
Regulation of spermatogenesis by a local functional axis in the testis: Role of the basement membrane–derived noncollagenous 1 domain peptide, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Regulation of the blood–testis barrier by a local axis in the testis: Role of laminin α2 in the basement membrane, Ying Gao, Dolores D. Mruk, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant, Haiqi Chen, Ying Gao, Dolores D. Mruk, and C. Yan Cheng
Sperm release at spermiation is regulated by changes in the organization of actin- and microtubule-based cytoskeletons at the apical ectoplasmic specialization—A study using the adjudin model, Linxi Li, Elizabeth I. Tang, Haiqi Chen, Qing-Quan Lian, Renshan Ge, Bruno Silvestrini, and C. Yan Cheng
Submissions from 2016
A first-in-human trial of MIV-150 and zinc acetate co-formulated in a carrageenan gel: Safety, pharmacokinetics, acceptability, adherence and pharmacodynamics, Barbara Friedland, Craig Hoesley, Marlena Gehret Plagianos, Elena Hoskin, Shimin Zhang, Natalia Teleshova, Mohcine Alami, Lea Novak, Kyle Kleinbeck, Lauren L. Katzen, Thomas Zydowsky, José Fernández-Romero, and George W. Creasy
AKAP9, a regulator of microtubule dynamics, contributes to blood-testis barrier function, Deepak Venkatesh, Dolores D. Mruk, Jan M. Herter, Xavier Cullere, Katarzyna Chojnacka, C. Yan Cheng, and Tanya N. Mayadas
A novel microbicide/contraceptive intravaginal ring protects macaque genital mucosa against SHIV-RT infection ex vivo, Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael Cooney, Melissa Robbiani, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
A small molecule, which competes with MAdCAM-1, activates integrin α4β7 and fails to prevent mucosal transmission of SHIV-SF162P3, Geraldine Arrode-Bruses, Diana J. Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, and Elena Martinelli
Baseline predictors of high adherence to a coitally dependent microbicide gel based on an objective marker of use: Findings from the Carraguard Phase 3 Trial, Barbara Friedland, Marie Stoner, Michelle Chau, Marlena Gehret Plagianos, Sumentheran N. Govender, Neetha S. Morar, Lydia Altini, Stephanie Skoler-Karpoff, Khatija Ahmed, Gita Ramjee, Constance Monedi, Robin A. Maguire, and Pekka Lahteenmaki
Biology of the Sertoli cell in the fetal, pubertal, and adult mammalian testis, Katarzyna Chojnacka, Marta Zarzycka, and Dolores D. Mruk
Cell polarity proteins and spermatogenesis, Ying Gao, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng
Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption, Nan Li, Dolores D. Mruk, Ka-Wai Mok, Michelle W.M. Li, Chris K.C. Wong, Will M. Lee, Daishu Han, Bruno Silvestrini, and C. Yan Cheng
Development, function and fate of fetal Leydig cells, Qing Wen, C. Yan Cheng, and Yi-Xun Liu
Does cell polarity matter during spermatogenesis?, Ying Gao and C. Yan Cheng
Editorial: It is time for new male contraceptives!, Christina Wang, Régine Sitruk-Ware, and David Serfaty
Effective delivery of male contraceptives behind the blood-testis barrier (BTB)—Lesson from adjudin, Haiqi Chen, Dolores D. Mruk, Weiliang Xia, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng
Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal, Dolores D. Mruk
F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis, Ying Gao, Dolores D. Mruk, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
Formin 1 regulates microtubule and F-actin organization to support spermatid transport during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng
Hormonal contraception and thrombosis, Régine Sitruk-Ware
Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells, Katarzyna Chojnacka, Marta Zarzycka, Anna Hejmej, Dolores D. Mruk, Ewelina Gorowska, Malgorzata Kotula-Balak, Monika Klimek, and Barbara Bilinska
Impact on hepatic estrogen-sensitive proteins by a 1-year contraceptive vaginal ring delivering Nestorone® and ethinyl estradiol, David F. Archer, M.A. Thomas, Jacqueline Conard, Ruth Merkatz, George W. Creasy, Kevin Roberts, Marlena Gehret Plagianos, Diana Blithe, and Régine Sitruk-Ware
Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk
In vitro exposure to PC-1005 and cervicovaginal lavage fluid from women vaginally administered PC-1005 inhibits HIV-1 and HSV-2 infection in human cervical mucosa, Guillermo Villegas, Giulia Calenda, Shimin Zhang, Olga Mizenina, Kyle Kleinbeck, Michael Cooney, Craig Hoesley, George W. Creasy, Barbara Friedland, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel, Akiva P. Novetsky, Marla J. Keller, Ana Gradissimo, Zigui Chen, Stephanie L. Morgan, Xiaonan Xue, Howard D. Strickler, José Fernández-Romero, Robert Burk, and Mark H. Einstein
Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?, Nan Li, Dolores D. Mruk, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng
Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells, Tito T. Jesus, Pedro F. Oliveira, Joaquina Silva, Alberto Barros, Rita Ferreira, Mario Sousa, C. Yan Cheng, Branca M. Silva, and Marco G. Alves
« Manifesto » de Paris : le temps est venu de disposer de nouvelles méthodes contraceptives masculines, David Serfaty, Régine Sitruk-Ware, Christina Wang, and Eberhard Nieschlag
Men's understanding of and experiences during the postcircumcision abstinence period: Results from a field study of ShangRing circumcision during routine clinical services in Kenya and Zambia, Mark Barone, Philip S. Li, Robert Zulu, Quentin Awori, Kawango Agot, Stephanie Combes, Raymond Otieno Simba, Richard K. Lee, Catherine Hart, Jaim Jou Lai, Zude Zyambo, Marc Goldstein, Paul Feldblum, and David C. Sokal
Multipurpose prevention approaches with antiretroviral-based formulations, Ninochka Jean-Pierre, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Samantha Seidor, Michael Cooney, Meredith R. Clark, Gustavo F. Doncel, Melissa Robbiani, Thomas Zydowsky, Natalia Teleshova, and José Fernández-Romero
Overexpression of plastin 3 in Sertoli cells disrupts actin microfilament bundle homeostasis and perturbs the tight junction barrier, Nan Li, Will M. Lee, and C. Yan Cheng
Patent: Myelin regeneration with androgens, Régine Sitruk-Ware, Michael Schumacher, Abdelmouman Ghoumari, Said Ghandour, Rashad Hussain, and Bartosz Bielecki
Patent: Neuroprotection and myelin repair using Nestorone®, Régine Sitruk-Ware, Michael Schumacher, Maria Helmut, Roberta Brinton, Martine El-Etr, Abdelmouman Ghoumari, and Rachida Guennoun
Planar cell polarity (PCP) proteins and spermatogenesis, Haiqi Chen and C. Yan Cheng
Planar cell polarity (PCP) protein Vangl2 regulates ectoplasmic specialization dynamics via its effects on actin microfilaments in the testes of male rats, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis, Nan Li, Chris K.C. Wong, and C. Yan Cheng
Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells, Ying Gao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
PolyICLC exerts pro- and anti-HIV effects on the DC-T cell milieu in vitro and in vivo, Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres M. Salazar, Michael Piatak Jr., Jeffrey D. Lifson, Melissa Robbiani, and Nina Derby
Rectal HSV-2 infection may increase rectal SIV acquisition even in the context of SIVΔnef vaccination, Natalia Guerra-Perez, Meropi Aravantinou, Filippo Veglia, Diana J. Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli
Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis, Elizabeth I. Tang, Dolores D. Mruk, and C. Yan Cheng
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43, Nan Li, Dolores D. Mruk, Haiqi Chen, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng
Risk of pregnancy in breastfeeding mothers: Role of the progesterone vaginal ring on birth spacing, Régine Sitruk-Ware, Saumya RamaRao, Ruth Merkatz, and John Townsend
Sertoli cell Wt1 regulates peritubular myoid cell and fetal leydig cell differentiation during fetal testis development, Qing Wen, Yuqian Wang, Ji-Xin Tang, C. Yan Cheng, and Yi-Xun Liu
Surgical outcomes of newly trained ShangRing circumcision providers, Quentin Awori, Richard K. Lee, Philip S. Li, Robert Zulu, Kawango Agot, Stephanie Combes, Raymond Otieno Simba, Catherine Hart, Jaim Jou Lai, Zude Zyambo, Marc Goldstein, Paul Feldblum, and Mark Barone
The control of male fertility by spermatid-specific factors: Searching for contraceptive targets from spermatozoon’s head to tail, Su-Ren Chen, Alia Batool, Yu-Qian Wang, Xiao-Xia Hao, Chawn-Shang Chang, C. Yan Cheng, and Yi-Xun Liu
Transport of germ cells across the seminiferous epithelium during spermatogenesis—The involvement of both actin- and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Xiang Xiao, Ying Gao, Darren S. Chu, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
Submissions from 2015
Actin binding proteins in blood–testis barrier function, Nan Li, Dolores D. Mruk, and C. Yan Cheng
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Will M. Lee, Daishu Han, and C. Yan Cheng
Adjudin – A male contraceptive with other biological activities, Yan Ho Cheng, Weiliang Xia, Elissa W.P. Wong, Qian Reuben Xie, Jiaxiang Shao, Tengyuan Liu, Yizhou Quan, Tingting Zhang, Xiao Yang, Keyi Geng, Bruno Silvestrini, and C. Yan Cheng
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway, Yizhou Quan, Li Xia, Jiaxiang Shao, Shankai Yin, C. Yan Cheng, Weiliang Xia, and Wei-Qiang Gao
A dose-finding, cross-over study to evaluate the effect of a Nestorone®/Estradiol transdermal gel delivery on ovulation suppression in normal ovulating women, Vivian Brache; Ruth Merkatz; Narender Kumar; Cristian Jesam Gaete; Heather Sussman; Elena Hoskin; Kevin Roberts; Mohcine Alami; DeShawn Taylor; Aidelis Jorge; Horacio B. Croxatto; Ellen Lorange; Daniel R. Mishell, Jr.; and Régine Sitruk-Ware
An intravaginal ring for the simultaneous delivery of an HIV-1 maturation inhibitor and reverse-transcriptase inhibitor for prophylaxis of HIV transmission, Shweta Ugaonkar, Justin T. Clark, Lexie B. English, Todd J. Johnson, Karen W. Buckheit, Robert J. Bahde, Daniel H. Appella, Robert W. Buckheit Jr., and Patrick F. Kiser
A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Samantha Seidor, Olga Mizenina, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Keith Levendosky, Jessica Kenney, Meropi Aravantinou, Nina Derby, Brooke Grasperge, Agegnehu Gettie, James F. Blanchard, Narender Kumar, Kevin Roberts, Melissa Robbiani, José Fernández-Romero, and Thomas Zydowsky
Applying emerging science to contraception research: Implications for the clinic, Régine Sitruk-Ware and Anita Nath
Biomedical research at the Population Council, Population Council
Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells, Xu Li, Cuixia Gao, Yupei Wu, C. Yan Cheng, Weiliang Xia, and Zhiping Zhang