The Population Council’s Center for Biomedical Research (CBR) is a vibrant hub of scientific investigation and product development. Our scientists address critical questions in reproductive health and develop innovative products that protect the health and well-being of millions of people worldwide. CBR is located at Rockefeller University in New York City.

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Submissions from 2017

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MAP/Microtubule affinity-regulating kinase, Elizabeth I. Tang and C. Yan Cheng

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Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system, Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu

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MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1, Olga Mizenina, Mayla Hsu, Ninochka Jean-Pierre, Meropi Aravantinou, Keith Levendosky, Maria Gabriela Paglini, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero

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MZC gel inhibits SHIV-RT and HSV-2 in macaque vaginal mucosa and SHIV-RT in rectal mucosa, Giulia Calenda, Guillermo Villegas, Patrick Barnable, Claudia Litterst, Keith Levendosky, Agegnehu Gettie, Michael Cooney, James Blanchard, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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Nestorone® (NES) a novel progestin for non-oral contraception: Structure-activity relationships and brain metabolism studies, Narender Kumar, Jerome Fagart, Philippe Liere, Scott J. Mitchell, Alanah R. Knibb, Isabelle Petit-Topin, Marion Rame, Martine El-Etr, Michael Schumacher, Jeremy J. Lambert, Marie-Edith Rafestin-Oblin, and Régine Sitruk-Ware

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Patent: Nestorone®/estradiol transdermal gel, Régine Sitruk-Ware, Dario Norberto Ramon Carrara, and Arnaud Grenier

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Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2, Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng

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Pixuna virus modifies host cell cytoskeleton to secure infection, Pedro Ignacio Gil, Guillermo Albrieu-Llinás, Estela Cecilia Mlewski, Marina Monetti, Laura Fozzatti, Cecilia Cuffini, José Fernández-Romero, Patricia Kunda, and Maria Gabriela Paglini

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Regulation of spermatogenesis by a local functional axis in the testis: Role of the basement membrane–derived noncollagenous 1 domain peptide, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Regulation of the blood–testis barrier by a local axis in the testis: Role of laminin α2 in the basement membrane, Ying Gao, Dolores D. Mruk, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant, Haiqi Chen, Ying Gao, Dolores D. Mruk, and C. Yan Cheng

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Sperm release at spermiation is regulated by changes in the organization of actin- and microtubule-based cytoskeletons at the apical ectoplasmic specialization—A study using the adjudin model, Linxi Li, Elizabeth I. Tang, Haiqi Chen, Qing-Quan Lian, Renshan Ge, Bruno Silvestrini, and C. Yan Cheng

Submissions from 2016

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A first-in-human trial of MIV-150 and zinc acetate co-formulated in a carrageenan gel: Safety, pharmacokinetics, acceptability, adherence and pharmacodynamics, Barbara Friedland, Craig Hoesley, Marlena Gehret Plagianos, Elena Hoskin, Shimin Zhang, Natalia Teleshova, Mohcine Alami, Lea Novak, Kyle Kleinbeck, Lauren L. Katzen, Thomas Zydowsky, José Fernández-Romero, and George W. Creasy

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AKAP9, a regulator of microtubule dynamics, contributes to blood-testis barrier function, Deepak Venkatesh, Dolores D. Mruk, Jan M. Herter, Xavier Cullere, Katarzyna Chojnacka, C. Yan Cheng, and Tanya N. Mayadas

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A novel microbicide/contraceptive intravaginal ring protects macaque genital mucosa against SHIV-RT infection ex vivo, Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael Cooney, Melissa Robbiani, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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A small molecule, which competes with MAdCAM-1, activates integrin α4β7 and fails to prevent mucosal transmission of SHIV-SF162P3, Geraldine Arrode-Bruses, Diana J. Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, and Elena Martinelli

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Baseline predictors of high adherence to a coitally dependent microbicide gel based on an objective marker of use: Findings from the Carraguard Phase 3 Trial, Barbara Friedland, Marie Stoner, Michelle Chau, Marlena Gehret Plagianos, Sumentheran N. Govender, Neetha S. Morar, Lydia Altini, Stephanie Skoler-Karpoff, Khatija Ahmed, Gita Ramjee, Constance Monedi, Robin A. Maguire, and Pekka Lahteenmaki

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Biology of the Sertoli cell in the fetal, pubertal, and adult mammalian testis, Katarzyna Chojnacka, Marta Zarzycka, and Dolores D. Mruk

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Cell polarity proteins and spermatogenesis, Ying Gao, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng

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Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption, Nan Li, Dolores D. Mruk, Ka-Wai Mok, Michelle W.M. Li, Chris K.C. Wong, Will M. Lee, Daishu Han, Bruno Silvestrini, and C. Yan Cheng

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Development, function and fate of fetal Leydig cells, Qing Wen, C. Yan Cheng, and Yi-Xun Liu

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Does cell polarity matter during spermatogenesis?, Ying Gao and C. Yan Cheng

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Editorial: It is time for new male contraceptives!, Christina Wang, Régine Sitruk-Ware, and David Serfaty

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Effective delivery of male contraceptives behind the blood-testis barrier (BTB)—Lesson from adjudin, Haiqi Chen, Dolores D. Mruk, Weiliang Xia, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng

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Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal, Dolores D. Mruk

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F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis, Ying Gao, Dolores D. Mruk, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Formin 1 regulates microtubule and F-actin organization to support spermatid transport during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Hormonal contraception and thrombosis, Régine Sitruk-Ware

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Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells, Katarzyna Chojnacka, Marta Zarzycka, Anna Hejmej, Dolores D. Mruk, Ewelina Gorowska, Malgorzata Kotula-Balak, Monika Klimek, and Barbara Bilinska

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Impact on hepatic estrogen-sensitive proteins by a 1-year contraceptive vaginal ring delivering Nestorone® and ethinyl estradiol, David F. Archer, M.A. Thomas, Jacqueline Conard, Ruth Merkatz, George W. Creasy, Kevin Roberts, Marlena Gehret Plagianos, Diana Blithe, and Régine Sitruk-Ware

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Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk

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In vitro exposure to PC-1005 and cervicovaginal lavage fluid from women vaginally administered PC-1005 inhibits HIV-1 and HSV-2 infection in human cervical mucosa, Guillermo Villegas, Giulia Calenda, Shimin Zhang, Olga Mizenina, Kyle Kleinbeck, Michael Cooney, Craig Hoesley, George W. Creasy, Barbara Friedland, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel, Akiva P. Novetsky, Marla J. Keller, Ana Gradissimo, Zigui Chen, Stephanie L. Morgan, Xiaonan Xue, Howard D. Strickler, José Fernández-Romero, Robert Burk, and Mark H. Einstein

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Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?, Nan Li, Dolores D. Mruk, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells, Tito T. Jesus, Pedro F. Oliveira, Joaquina Silva, Alberto Barros, Rita Ferreira, Mario Sousa, C. Yan Cheng, Branca M. Silva, and Marco G. Alves

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« Manifesto » de Paris : le temps est venu de disposer de nouvelles méthodes contraceptives masculines, David Serfaty, Régine Sitruk-Ware, Christina Wang, and Eberhard Nieschlag

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Men's understanding of and experiences during the postcircumcision abstinence period: Results from a field study of ShangRing circumcision during routine clinical services in Kenya and Zambia, Mark Barone, Philip S. Li, Robert Zulu, Quentin Awori, Kawango Agot, Stephanie Combes, Raymond Otieno Simba, Richard K. Lee, Catherine Hart, Jaim Jou Lai, Zude Zyambo, Marc Goldstein, Paul Feldblum, and David C. Sokal

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Multipurpose prevention approaches with antiretroviral-based formulations, Ninochka Jean-Pierre, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Samantha Seidor, Michael Cooney, Meredith R. Clark, Gustavo F. Doncel, Melissa Robbiani, Thomas Zydowsky, Natalia Teleshova, and José Fernández-Romero

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Overexpression of plastin 3 in Sertoli cells disrupts actin microfilament bundle homeostasis and perturbs the tight junction barrier, Nan Li, Will M. Lee, and C. Yan Cheng

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Planar cell polarity (PCP) proteins and spermatogenesis, Haiqi Chen and C. Yan Cheng

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Planar cell polarity (PCP) protein Vangl2 regulates ectoplasmic specialization dynamics via its effects on actin microfilaments in the testes of male rats, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis, Nan Li, Chris K.C. Wong, and C. Yan Cheng

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Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells, Ying Gao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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PolyICLC exerts pro- and anti-HIV effects on the DC-T cell milieu in vitro and in vivo, Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres M. Salazar, Michael Piatak Jr., Jeffrey D. Lifson, Melissa Robbiani, and Nina Derby

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Rectal HSV-2 infection may increase rectal SIV acquisition even in the context of SIVΔnef vaccination, Natalia Guerra-Perez, Meropi Aravantinou, Filippo Veglia, Diana J. Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis, Elizabeth I. Tang, Dolores D. Mruk, and C. Yan Cheng

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Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43, Nan Li, Dolores D. Mruk, Haiqi Chen, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng

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Risk of pregnancy in breastfeeding mothers: Role of the progesterone vaginal ring on birth spacing, Régine Sitruk-Ware, Saumya RamaRao, Ruth Merkatz, and John Townsend

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Sertoli cell Wt1 regulates peritubular myoid cell and fetal leydig cell differentiation during fetal testis development, Qing Wen, Yuqian Wang, Ji-Xin Tang, C. Yan Cheng, and Yi-Xun Liu

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Surgical outcomes of newly trained ShangRing circumcision providers, Quentin Awori, Richard K. Lee, Philip S. Li, Robert Zulu, Kawango Agot, Stephanie Combes, Raymond Otieno Simba, Catherine Hart, Jaim Jou Lai, Zude Zyambo, Marc Goldstein, Paul Feldblum, and Mark Barone

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The control of male fertility by spermatid-specific factors: Searching for contraceptive targets from spermatozoon’s head to tail, Su-Ren Chen, Alia Batool, Yu-Qian Wang, Xiao-Xia Hao, Chawn-Shang Chang, C. Yan Cheng, and Yi-Xun Liu

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Transport of germ cells across the seminiferous epithelium during spermatogenesis—The involvement of both actin- and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Xiang Xiao, Ying Gao, Darren S. Chu, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

Submissions from 2015

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Actin binding proteins in blood–testis barrier function, Nan Li, Dolores D. Mruk, and C. Yan Cheng

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Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Will M. Lee, Daishu Han, and C. Yan Cheng

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Adjudin – A male contraceptive with other biological activities, Yan Ho Cheng, Weiliang Xia, Elissa W.P. Wong, Qian Reuben Xie, Jiaxiang Shao, Tengyuan Liu, Yizhou Quan, Tingting Zhang, Xiao Yang, Keyi Geng, Bruno Silvestrini, and C. Yan Cheng

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Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway, Yizhou Quan, Li Xia, Jiaxiang Shao, Shankai Yin, C. Yan Cheng, Weiliang Xia, and Wei-Qiang Gao

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A dose-finding, cross-over study to evaluate the effect of a Nestorone®/Estradiol transdermal gel delivery on ovulation suppression in normal ovulating women, Vivian Brache; Ruth Merkatz; Narender Kumar; Cristian Jesam Gaete; Heather Sussman; Elena Hoskin; Kevin Roberts; Mohcine Alami; DeShawn Taylor; Aidelis Jorge; Horacio B. Croxatto; Ellen Lorange; Daniel R. Mishell, Jr.; and Régine Sitruk-Ware

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An intravaginal ring for the simultaneous delivery of an HIV-1 maturation inhibitor and reverse-transcriptase inhibitor for prophylaxis of HIV transmission, Shweta Ugaonkar, Justin T. Clark, Lexie B. English, Todd J. Johnson, Karen W. Buckheit, Robert J. Bahde, Daniel H. Appella, Robert W. Buckheit Jr., and Patrick F. Kiser

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A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Samantha Seidor, Olga Mizenina, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Keith Levendosky, Jessica Kenney, Meropi Aravantinou, Nina Derby, Brooke Grasperge, Agegnehu Gettie, James F. Blanchard, Narender Kumar, Kevin Roberts, Melissa Robbiani, José Fernández-Romero, and Thomas Zydowsky

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Applying emerging science to contraception research: Implications for the clinic, Régine Sitruk-Ware and Anita Nath

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Biomedical research at the Population Council, Population Council

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Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells, Xu Li, Cuixia Gao, Yupei Wu, C. Yan Cheng, Weiliang Xia, and Zhiping Zhang

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EB1 regulates tubulin and actin cytoskeletal networks at the Sertoli cell blood-testis barrier in male rats: An in vitro study, Elizabeth I. Tang, Ka-Wai Mok, Will M. Lee, and C. Yan Cheng

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Effects of a one year reusable contraceptive vaginal ring on vaginal microflora and the risk of vaginal infection: An open-label prospective evaluation, Yong-mei Huang, Ruth Merkatz, Sharon L. Hillier, Kevin Roberts, Diana Blithe, Régine Sitruk-Ware, and Mitchell Creinin

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European Society of Contraception statement on contraception in obese women, Gabriele S. Merki-Feld, Sven O. Skouby, David Serfaty, Medard M. Lech, Johannes Bitzer, Pier Giorgio Crosignani, Angelo Cagnacci, and Régine Sitruk-Ware

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Ezrin: A regulator of actin microfilaments in cell junctions of the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng

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Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics, N. Ece Gungor-Ordueri and C. Yan Cheng

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Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activity, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Daishu Han, Will M. Lee, and C. Yan Cheng

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Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus, Keith Levendosky, Olga Mizenina, Elena Martinelli, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Kyle Kleinbeck, Thierry Bonnaire, Melissa Robbiani, Thomas Zydowsky, Barry R. O'Keefe, and José Fernández-Romero

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Hormonal contraception and the risk of HIV acquisition: An individual participant data meta-analysis, Charles S. Morrison, Pai-lien Chen, Cynthia Kwok, Jared M. Baeten, Joelle Brown, Angela M. Cook, Lut Van Damme, Sinead Delany-Moretlwe, Suzanna C. Francis, Barbara Friedland, Richard J. Hayes, Renee Heffron, Saidi H. Kapiga, Quarraisha Abdool Karim, Stephanie Skoler-Karpoff, Rupert Kaul, R. Scott McClelland, Sheena McCormack, Nuala McGrath, Landon Myer, Helen Rees, Ariane van der Straten, Deborah Watson-Jones, Janneke van de Wijgert, Randy Stalter, and Nicola Low

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Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction, Nan Li, Zhenghui Liu, Yue Zhang, Qiaoyuan Chen, C. Yan Cheng, Will M. Lee, Yong-Mei Chen, and Daishu Han

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MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model, Patrick Barnable, Giulia Calenda, Thierry Bonnaire, Radhika Menon, Keith Levendosky, Agegnehu Gettie, James F. Blanchard, Michael Cooney, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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Multipurpose prevention technologies: The future of HIV and STI protection, José Fernández-Romero, Carolyn Deal, Betsy C. Herold, John Schiller, Dorothy Patton, Thomas Zydowsky, Joseph W. Romano, Christopher D. Petro, and Manjulaa Narasimhan

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Not just HIV: Preventing other viral sexually transmitted infections, José Fernández-Romero

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Preclinical assessments of vaginal microbicide candidate safety and efficacy, José Fernández-Romero, Natalia Teleshova, Thomas Zydowsky, and Melissa Robbiani

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Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex, Martine El-Etr, Marion Rame, Celine Boucher, Abdel M. Ghoumari, Narender Kumar, Philippe Liere, Antoine Pianos, Michael Schumacher, and Régine Sitruk-Ware

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Regulation of blood-testis barrier by actin binding proteins and protein kinases, Nan Li, Elizabeth I. Tang, and C. Yan Cheng

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Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection, Natalia Guerra-Perez, Ines Frank, Filippo Veglia, Meropi Aravantinou, Diana J. Goode, James L. Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice, Zhenghui Liu, Shutao Zhao, Qiaoyuan Chen, Keqin Yan, Peng Liu, Nan Li, C. Yan Cheng, Will M. Lee, and Daishu Han

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rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat Sertoli cells. An in vitro study, Ka-Wai Mok, Haiqi Chen, Will M. Lee, and C. Yan Cheng

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Safety, pharmacokinetics and acceptability of PC-1005 for vaginal use, Population Council

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Sertoli cells are the target of environmental toxicants in the testis—A mechanistic and therapeutic insight, Ying Gao, Dolores D. Mruk, and C. Yan Cheng

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Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes, Linlin Su, Yufei Zhang, C. Yan Cheng, Will M. Lee, Keping Ye, and Dahai Hu

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The mammalian blood–testis barrier: Its biology and regulation, Dolores D. Mruk and C. Yan Cheng

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The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration, Maria Meyer, Maria Claudia Gonzalez Deniselle, Laura Garay, Régine Sitruk-Ware, Rachida Guennoun, Michael Schumacher, and Alejandro De Nicola

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The Warburg effect revisited—Lesson from the Sertoli cell, Pedro F. Oliveira, Ana D. Martins, Ana C. Moreira, C. Yan Cheng, and Marco G. Alves

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Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model, C. Yan Cheng

Submissions from 2014

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Acceptability of a transdermal gel-based male hormonal contraceptive in a randomized controlled trial, Mara Y. Roth, Grace Shih, Niloufar Ilani, Christina Wang, Stephanie T. Page, William J. Bremner, Ronald S. Swerdloff, Régine Sitruk-Ware, Diana Blithe, and John K. Amory

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Acceptability of the Nestorone®/ethinyl estradiol contraceptive vaginal ring: Development of a model; implications for introduction, Ruth Merkatz, Marlena Gehret Plagianos, Michael Cooney, Elena Hoskin, Paul C. Hewett, and Barbara Mensch

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A combination microbicide gel protects macaques against vaginal SHIV-RT infection, but only partially reduces HSV-2 infection after a single high-dose co-challenge, Mayla Hsu, Meropi Aravantinou, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Nina Derby, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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Actin binding proteins, spermatid transport and spermiation, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, Elizabeth I. Tang, Daishu Han, Will M. Lee, Elissa W.P. Wong, and C. Yan Cheng

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A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants, Patrick Barnable, Giulia Calenda, Louise Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Michael Cooney, Kevin Roberts, Rhoda Sperling, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, Melissa Robbiani, and Natalia Teleshova

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A novel intravaginal ring (IVR) protects macaques against SHIV-RT infection and reduces HSV-2 shedding after repeated SHIV-RT/HSV-2 co-challenge, Thomas Zydowsky, Jessica Kenney, Meropi Aravantinou, Shweta Ugaonkar, Nina Derby, Larisa Kizima, Shimin Zhang, Olga Mizenina, José Fernández-Romero, and Melissa Robbiani

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Antiviral activity and mode of action of Griffithsin against HSV-2 and HPV: Preliminary studies of a potential non-ARV combination microbicide, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Larisa Kizima, Aixa Rodriguez, Ninochka Jean-Pierre, Melissa Robbiani, Barry R. O'Keefe, Thomas Zydowsky, and José Fernández-Romero

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A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV, Larisa Kizima, Aixa Rodriguez, Jessica Kenney, Nina Derby, Olga Mizenina, Radhika Menon, Samantha Seidor, Shimin Zhang, Keith Levendosky, Ninochka Jean-Pierre, Pavel Pugach, Guillermo Villegas, Brian E. Ford, Agegnehu Gettie, James F. Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Maria Gabriela Paglini, Natalia Teleshova, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero

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A randomized study on pharmacodynamic effects of vaginal rings delivering the progesterone receptor modulator ulipristal acetate: Research for a novel estrogen-free, method of contraception, Yong-mei Huang, Jeffrey T. Jensen, Vivian Brache, Leila Cochen, Alistair Williams, Marie-José Miranda, Horacio B. Croxatto, Narender Kumar, Heather Sussman, Elena Hoskin, Marlena Gehret Plagianos, Kevin Roberts, Ruth Merkatz, Diana Blithe, and Régine Sitruk-Ware

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Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium, C. Yan Cheng and Dolores D. Mruk

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Biology of spermatogenesis—The challenges ahead, C. Yan Cheng

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Cytokines, polarity proteins, and endosomal protein trafficking and signaling—The Sertoli cell blood–testis barrier system in vitro as a study model, Xiang Xiao, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng