Submissions from 2014
Thyroid hormone function in the rat testis, Ying Gao, Will M. Lee, and C. Yan Cheng
Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits, Carolien Grammen, Myriam Baes, Steven Haenen, Jasper Verguts, Koen Augustyns, Thomas Zydowsky, Paolo La Colla, Patrick Augustijns, and Joachim Brouwers
Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis, Qing Wen, Qiao-Song Zheng, Xi-Xia Li, Zhao-Yuan Hu, Fei Gao, C. Yan Cheng, and Yi-Xun Liu
Submissions from 2013
7a-methyl-19-nortestosterone (MENT®): The Population Council's contribution to research on male contraception and treatment of hypogonadism, Eberhard Nieschlag, Narender Kumar, and Régine Sitruk-Ware
Actin cross-linking protein palladin and spermatogenesis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng
Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation, Jiaxiang Shao, Tengyuan Liu, Qian Reuben Xie, Tingting Zhang, Hemei Yu, Boshi Wang, Weihai Ying, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia
Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP), Xiao-jing Qian, Yan Ho Cheng, Pranitha Jenardhanan, Dolores D. Mruk, Premendu P. Mathur, Weiliang Xia, Bruno Silvestrini, and C. Yan Cheng
A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo, Jessica Kenney; Aixa Rodriguez; Larisa Kizima; Samantha Seidor; Radhika Menon; Ninochka Jean-Pierre; Pavel Pugach; Keith Levendosky; Nina Derby; Agegnehu Gettie; James Blanchard; Michael Piatak, Jr.; Jeffrey D. Lifson; Gabriela Paglini; Thomas Zydowsky; Melissa Robbiani; and José Fernández-Romero
Breast cancer resistance protein (Bcrp) and the testis—An unexpected turn of events, Xiao-jing Qian, Yan Ho Cheng, Dolores D. Mruk, and C. Yan Cheng
Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, and C. Yan Cheng
Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills, Régine Sitruk-Ware and Anita Nath
Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone® gels, Mara Y. Roth, Niloufar Ilani, Christina Wang, Stephanie T. Page, William J. Bremner, Ronald S. Swerdloff, Clint Dart, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, and John K. Amory
Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors, Axel Mann, Nikolas Friedrich, Anders Krarup, Jacqueline Weber, Emanuel Stiegeler, Birgit Dreier, Pavel Pugach, Melissa Robbiani, Tina Riedel, Kerstin Moehle, John A. Robinson, Peter Rusert, Andreas Pluckthun, and Alexandra Trkola
Contraception technology: Past, present and future, Régine Sitruk-Ware; Anita Nath; and Daniel R. Mishell, Jr.
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood–testis barrier axis via its effects on protein recruitment and distribution, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng
Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, and Dolores D. Mruk
Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis, Stephen Y.T. Li, Dolores D. Mruk, and C. Yan Cheng
Germ cells contribute to the function of the Sertoli cell barrier: An in vitro study, Linlin Su, Ilona A. Kopera-Sobota, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk
Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans, Kun Li, Ya Ni, Yi He, Wen-Ying Chen, Jian-Xin Lu, C. Yan Cheng, Renshan Ge, and Qi-Xian Shi
In search of the optimal delivery method for anti-HIV microbicides: Are intravaginal rings the way forward?, Nina Derby, Thomas Zydowsky, and Melissa Robbiani
Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat, Xiang Xiao, C. Yan Cheng, and Dolores D. Mruk
Intercellular adhesion molecules (ICAMs) and spermatogenesis, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng
Male contraceptive Adjudin is a potential anti-cancer drug, Qian Reuben Xie, Yewei Liu, Jiaxiang Shao, Jian Yang, Tengyuan Liu, Tingting Zhang, Boshi Wang, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia
MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis, Elizabeth I. Tang and Dolores D. Mruk
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics, Elissa W.P. Wong and C. Yan Cheng
New vision for contraceptive research and development, Régine Sitruk-Ware and Peter J. Donaldson
Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, Pearl P.Y. Lie, and C. Yan Cheng
p-FAK-Tyr^397 regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization, Hin Ting Wan, Dolores D. Mruk, Stephen Y.T. Li, Ka-Wai Mok, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng
Progesterone and related progestins: Potential new health benefits, Régine Sitruk-Ware and Martine El-Etr
RAI14 (retinoic acid induced protein 14) is an F-actin regulator—Lesson from the testis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng
Rai14 (Retinoic Acid Induced Protein 14) is involved in regulating F-Actin dynamics at the ectoplasmic specialization in the rat testis, Xiao-jing Qian, Dolores D. Mruk, and C. Yan Cheng
Regulation of actin dynamics and protein trafficking during spermatogenesis—Insights into a complex process, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng
Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the 'yin' and 'yang' effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng
Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Safety and adherence of a non-medicated intravaginal ring (IVR) (MTN-005), Population Council
Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex, Elissa W.P. Wong, Will M. Lee, and C. Yan Cheng
Signalling pathways regulating the blood–testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Simian immunodeficiency virus interactions with macaque dendritic cells, Natalia Teleshova, Nina Derby, Elena Martinelli, Pavel Pugach, Giulia Calenda, and Melissa Robbiani
Spermatogenesis, Mammals, C. Yan Cheng and Dolores D. Mruk
Statement on combined hormonal contraceptives containing third- or fourth-generation progestogens or cyproterone acetate, and the associated risk of thromboembolism, Johannes Bitzer, Jean-Jacques Amy, Rob Beerthuizen, Martin Birkhauser, Teresa Bombas, Mitchell Creinin, Philip Darney, Lisa Ferreira Vicente, Kristina Gemzell-Danielsson, Bruno Imthurn, Jeffrey T. Jensen, Andrew M. Kaunitz, Ali Kubba, Medard M. Lech, Diana Mansour, Gabriele Merki, Thomas Rabe, Katrina Sedlecki, David Serfaty, Jacques Seydoux, Lee P. Shulman, Régine Sitruk-Ware, Sven O. Skouby, Anne Szarewski, James Trussell, and Carolyn Westhoff
Targeting testis-specific proteins to inhibit spermatogenesis: Lesson from endocrine disrupting chemicals, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng
The apical ES–BTB–BM functional axis is an emerging target for toxicant-induced infertility, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng
The frequency of α4β7high memory CD4+ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection, Elena Martinelli; Filippo Veglia; Diana J. Goode; Natalia Guerra-Perez; Meropi Aravantinou; James Arthos; Michael Piatak, Jr.; Jeffrey D. Lifson; James Blanchard; Agegnehu Gettie; and Melissa Robbiani
The neural androgen receptor: A therapeutic target for myelin repair in chronic demyelination, Rashad Hussain, Abdel M. Ghoumari, Bartosz Bielecki, Jerome Steibel, Nelly Boehm, Philippe Liere, Wendy B. Macklin, Narender Kumar, Rene Habert, Sakina Mhaouty-Kodja, Francois Tronche, Régine Sitruk-Ware, Michael Schumacher, and M. Said Ghandour
Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary, Shanmugasundaram Nallasamy, Jaeyeon Kim, Régine Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi
Why do we need male contraceptives?, C. Yan Cheng and Dolores D. Mruk
Submissions from 2012
A new combination of testosterone and nestorone transdermal gels for male hormonal contraception, Niloufar Ilani, Mara Y. Roth, John K. Amory, Ronald S. Swerdloff, Clint Dart, Stephanie T. Page, William J. Bremner, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, and Christina Wang
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques, Rachel Singer, Paul Mawson, Nina Derby, Aixa Rodriguez, Larisa Kizima, Radhika Menon, Daniel Goldman, Jessica Kenney, Meropi Aravantinou, Samantha Seidor, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Melissa Robbiani, and Thomas Zydowsky
A peptide derived from laminin-γ3 reversibly impairs spermatogenesis in rats, Linlin Su, Dolores D. Mruk, Pearl P.Y. Lie, Bruno Silvestrini, and C. Yan Cheng
A single dose of a MIV-150/zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use, Jessica Kenney, Rachel Singer, Nina Derby, Meropi Aravantinou, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Shimin Zhang, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy, Edith Jasny, Suzanne Geer, Ines Frank, Panagiotis Vagenas, Meropi Aravantinou, Andres M. Salazar, Jeffrey D. Lifson, Michael Piatak Jr., Agegnehu Gettie, James L. Blanchard, and Melissa Robbiani
Drug transporters in spermatogenesis: A re-evaluation of recent data on P-glycoprotein, Dolores D. Mruk and C. Yan Cheng
Effects of a novel estrogen-free, progesterone receptor modulator-contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women, Vivian Brache; Régine Sitruk-Ware; A. Williams; Diana Blithe; Horacio B. Croxatto; Narender Kumar; Sushma Kumar; Yun-yen Tsong; Irving Sivin; Anita Nath; Heather Sussman; Leila Cochon; Marie-José Miranda; Veronica Reyes; Anibal Faundes; and Daniel R. Mishell, Jr.
Filamin A: A regulator of blood-testis barrier assembly during post-natal development, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis, Wenhui Su, Dolores D. Mruk, Pearl P.Y. Lie, Wing-Yee Lui, and C. Yan Cheng
Focal adhesion kinase-Tyr^407 and -Tyr^397 exhibit antagonistic effects on blood–testis barrier dynamics in the rat, Pearl P.Y. Lie, Dolores D. Mruk, Ka-Wai Mok, Linlin Su, Will M. Lee, and C. Yan Cheng
Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein, Mandana Rad, Jacobus Burggraaf, Régine Sitruk-Ware, Marieke L. de Kam, Adam F. Cohen, and Cornelius Kluft
In search of suitable in vitro models to study germ cell movement across the blood-testis barrier, Dolores D. Mruk and C. Yan Cheng
Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis, Elizabeth I. Tang, Xiang Xiao, Dolores D. Mruk, Xiao-jing Qian, Ka-Wai Mok, Pranitha Jenardhanan, Will M. Lee, Premendu P. Mathur, and C. Yan Cheng
Non-specific microbicide development: Then and now, Joseph W. Romano, Melissa Robbiani, Gustavo F. Doncel, and Thomas Moench
Postpartum unintended pregnancy and contraception practice among rural-to-urban migrant women in Shanghai, Yong-mei Huang, Ruth Merkatz, Jian-Zhong Kang, Kevin Roberts, Xiao-Yu Hu, Francis Di Donato, Régine Sitruk-Ware, and Li-nan Cheng
Progesterone receptors: A key for neuroprotection in experimental stroke, Ailing Liu, Isabelle Margaill, Shaodong Zhang, Florencia Labombarda, Berard Coqueran, Brigitte Delespierre, Philippe Liere, Catherine Marchand-Leroux, Bert W. O'Malley, John P. Lydon, Alejandro De Nicola, Régine Sitruk-Ware, Claudia Mattern, Michel Plotkine, Michael Schumacher, and Rachida Guennoun
Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
rpS6 regulates blood–testis barrier dynamics by affecting F-actin organization and protein recruitment, Ka-Wai Mok, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
The blood–testis barrier and its implications for male contraception, C. Yan Cheng and Dolores D. Mruk
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection, Meropi Aravantinou, Rachel Singer, Nina Derby, Giulia Calenda, Paul Mawson, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Guillermo Villegas, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, Natalia Teleshova, and Melissa Robbiani
The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood–testis barrier dynamics and spermatid polarity during spermatogenesis, Wenhui Su, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton, Marta Lydka, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk
Vasectomy reversal in humans, Aaron M. Bernie, E. Charles Osterberg, Peter J. Stahl, Ranjith Ramasamy, and Marc Goldstein
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high dose HSV-2 vaginal and rectal challenge, José Fernández-Romero, Ciby J. Abraham, Aixa Rodriguez, Larisa Kizima, Ninochka Jean-Pierre, Radhika Menon, Othell Begay, Samantha Seidor, Brian E. Ford, Pedro I. Gil, Jennifer Peters, David Katz, Melissa Robbiani, and Thomas Zydowsky
Submissions from 2011
7 α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: A preclinical study in the aged male orchidectomized rat model, M. Sinnesael, F. Callewaert, M. Morreels, Narender Kumar, Régine Sitruk-Ware, K. van Proeyen, P. Hespel, Steven Boonen, F. Claessens, and Dirk Vanderschueren
Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis, Michelle W.M. Li, Xiang Xiao, Dolores D. Mruk, Yee-ling Lam, Will M. Lee, Wing-Yee Lui, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng
Actin binding proteins and spermiogenesis: Some unexpected findings, C. Yan Cheng and Dolores D. Mruk
Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes, Ka-Wai Mok, Dolores D. Mruk, Pearl P.Y. Lie, Wing Yee Lui, and C. Yan Cheng
Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, Dolores D. Mruk, and Bruno Silvestrini
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
An in vitro system to study sertoli cell blood-testis barrier dynamics, Dolores D. Mruk and C. Yan Cheng
A study to assess the assembly of a functional blood–testis barrier in developing rat testes, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection, Ines Frank and Melissa Robbiani
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis, Yan Ho Cheng, Elissa W.P. Wong, and C. Yan Cheng
Characterization and functionality of proliferative human sertoli cells, Kitty Chui, Alpa Trivedi, C. Yan Cheng, Diana B. Cherbavaz, Paul F. Dazin, Ai Lam Thu Huynh, James B. Mitchell, Gabriel A. Rabinovich, Linda J. Noble-Haeusslein, and Constance M. John
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes, Xiang Xiao, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Desmosomes in the testis: Moving into an unchartered territory, Dolores D. Mruk and C. Yan Cheng
Differential nuclear receptor and gene expression in human endometrial adenocarcinoma cells: Regulation by a novel selective progesterone receptor modulator, KeumSil Hwang, Lyann Mitchell, Catherine Rapelje, and Patricia L. Morris
Drug transporters and blood–testis barrier function, Linlin Su, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Drug transporters, the blood–testis barrier, and spermatogenesis, Linlin Su, Dolores D. Mruk, and C. Yan Cheng
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes, Guo-Xin Hu, Binghai Zhao, Yanhui Chu, X.H. Li, Benson T. Akingbemi, Zhi-Qiang Zheng, and Renshan Ge
Emerging role for drug transporters at the blood-testis barrier, Dolores D. Mruk, Linlin Su, and C. Yan Cheng
Enhanced chemiluminescence (ECL) for routine immunoblotting. An inexpensive alternative to commercially available kits, Dolores D. Mruk and C. Yan Cheng
Environmental contaminants: Is male reproductive health at risk?, Dolores D. Mruk and C. Yan Cheng
Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2, Xue Ma, Qing-Quan Lian, Qiang Dong, and Renshan Ge
Environmental toxicants and male reproductive function, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Linlin Su, Erica R. Siu, Helen H.N. Yan, J. Mannu, Premendu P. Mathur, Michele Bonanomi, Bruno Silvestrini, and Dolores D. Mruk
Hormonal influences in multiple sclerosis: New therapeutic benefits for steroids, Martine El-Etr, Abdel M. Ghoumari, Régine Sitruk-Ware, and Michael Schumacher
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target, Elena Martinelli, Hugo Tharinger, Ines Frank, James Arthos, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro, Othell Begay, Ninochka Jean-Pierre, Ciby J. Abraham, Anne Chudolij, Samantha Seidor, Aixa Rodriguez, Brian E. Ford, Marcus Henderson, David Katz, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
Impacts of environmental toxicants on male reproductive dysfunction, Elissa W.P. Wong and C. Yan Cheng
Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood–testis-barrier-hemidesmosome functional axis in the testis, C. Yan Cheng, Pearl P.Y. Lie, Ka-Wai Mok, Yan Ho Cheng, Elissa W.P. Wong, Jayakanthan Mannu, Premendu P. Mathur, Helen H.N. Yan, and Dolores D. Mruk