Germ cell transport across the seminiferous epithelium during spermatogenesis

Document Type

Article (peer-reviewed)

Publication Date

2014

Abstract

Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.

DOI

10.1152/physiol.00001.2014

Language

English

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