Submissions from 2016
Impact on hepatic estrogen-sensitive proteins by a 1-year contraceptive vaginal ring delivering Nestorone® and ethinyl estradiol, David F. Archer, M.A. Thomas, Jacqueline Conard, Ruth Merkatz, George W. Creasy, Kevin Roberts, Marlena Gehret Plagianos, Diana Blithe, and Régine Sitruk-Ware
Planar cell polarity (PCP) proteins and spermatogenesis, Haiqi Chen and C. Yan Cheng
Planar cell polarity (PCP) protein Vangl2 regulates ectoplasmic specialization dynamics via its effects on actin microfilaments in the testes of male rats, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Effective delivery of male contraceptives behind the blood-testis barrier (BTB)—Lesson from adjudin, Haiqi Chen, Dolores D. Mruk, Weiliang Xia, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng
The control of male fertility by spermatid-specific factors: Searching for contraceptive targets from spermatozoon’s head to tail, Su-Ren Chen, Alia Batool, Yu-Qian Wang, Xiao-Xia Hao, Chawn-Shang Chang, C. Yan Cheng, and Yi-Xun Liu
Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk
Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells, Katarzyna Chojnacka, Marta Zarzycka, Anna Hejmej, Dolores D. Mruk, Ewelina Gorowska, Malgorzata Kotula-Balak, Monika Klimek, and Barbara Bilinska
Biology of the Sertoli cell in the fetal, pubertal, and adult mammalian testis, Katarzyna Chojnacka, Marta Zarzycka, and Dolores D. Mruk
Does cell polarity matter during spermatogenesis?, Ying Gao and C. Yan Cheng
Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells, Ying Gao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis, Ying Gao, Dolores D. Mruk, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
Cell polarity proteins and spermatogenesis, Ying Gao, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng
Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells, Tito T. Jesus, Pedro F. Oliveira, Joaquina Silva, Alberto Barros, Rita Ferreira, Mario Sousa, C. Yan Cheng, Branca M. Silva, and Marco G. Alves
Overexpression of plastin 3 in Sertoli cells disrupts actin microfilament bundle homeostasis and perturbs the tight junction barrier, Nan Li, Will M. Lee, and C. Yan Cheng
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43, Nan Li, Dolores D. Mruk, Haiqi Chen, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng
Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?, Nan Li, Dolores D. Mruk, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng
Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption, Nan Li, Dolores D. Mruk, Ka-Wai Mok, Michelle W.M. Li, Chris K.C. Wong, Will M. Lee, Daishu Han, Bruno Silvestrini, and C. Yan Cheng
Formin 1 regulates microtubule and F-actin organization to support spermatid transport during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng
Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis, Nan Li, Chris K.C. Wong, and C. Yan Cheng
Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal, Dolores D. Mruk
« Manifesto » de Paris : le temps est venu de disposer de nouvelles méthodes contraceptives masculines, David Serfaty, Régine Sitruk-Ware, Christina Wang, and Eberhard Nieschlag
Hormonal contraception and thrombosis, Régine Sitruk-Ware
Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis, Elizabeth I. Tang, Dolores D. Mruk, and C. Yan Cheng
AKAP9, a regulator of microtubule dynamics, contributes to blood-testis barrier function, Deepak Venkatesh, Dolores D. Mruk, Jan M. Herter, Xavier Cullere, Katarzyna Chojnacka, C. Yan Cheng, and Tanya N. Mayadas
Editorial: It is time for new male contraceptives!, Christina Wang, Régine Sitruk-Ware, and David Serfaty
Development, function and fate of fetal Leydig cells, Qing Wen, C. Yan Cheng, and Yi-Xun Liu
Transport of germ cells across the seminiferous epithelium during spermatogenesis—The involvement of both actin- and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Xiang Xiao, Ying Gao, Darren S. Chu, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
Sertoli cell Wt1 regulates peritubular myoid cell and fetal leydig cell differentiation during fetal testis development, Qing Wen, Yuqian Wang, Ji-Xin Tang, C. Yan Cheng, and Yi-Xun Liu
Submissions from 2015
A dose-finding, cross-over study to evaluate the effect of a Nestorone®/Estradiol transdermal gel delivery on ovulation suppression in normal ovulating women, Vivian Brache; Ruth Merkatz; Narender Kumar; Cristian Jesam Gaete; Heather Sussman; Elena Hoskin; Kevin Roberts; Mohcine Alami; DeShawn Taylor; Aidelis Jorge; Horacio B. Croxatto; Ellen Lorange; Daniel R. Mishell, Jr.; and Régine Sitruk-Ware
Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model, C. Yan Cheng
Adjudin – A male contraceptive with other biological activities, Yan Ho Cheng, Weiliang Xia, Elissa W.P. Wong, Qian Reuben Xie, Jiaxiang Shao, Tengyuan Liu, Yizhou Quan, Tingting Zhang, Xiao Yang, Keyi Geng, Bruno Silvestrini, and C. Yan Cheng
Sertoli cells are the target of environmental toxicants in the testis—A mechanistic and therapeutic insight, Ying Gao, Dolores D. Mruk, and C. Yan Cheng
Ezrin: A regulator of actin microfilaments in cell junctions of the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng
Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics, N. Ece Gungor-Ordueri and C. Yan Cheng
Effects of a one year reusable contraceptive vaginal ring on vaginal microflora and the risk of vaginal infection: An open-label prospective evaluation, Yong-mei Huang, Ruth Merkatz, Sharon L. Hillier, Kevin Roberts, Diana Blithe, Régine Sitruk-Ware, and Mitchell Creinin
Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus, Keith Levendosky, Olga Mizenina, Elena Martinelli, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Kyle Kleinbeck, Thierry Bonnaire, Melissa Robbiani, Thomas Zydowsky, Barry R. O'Keefe, and José Fernández-Romero
Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction, Nan Li, Zhenghui Liu, Yue Zhang, Qiaoyuan Chen, C. Yan Cheng, Will M. Lee, Yong-Mei Chen, and Daishu Han
Actin binding proteins in blood–testis barrier function, Nan Li, Dolores D. Mruk, and C. Yan Cheng
Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng
Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activity, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Daishu Han, Will M. Lee, and C. Yan Cheng
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Will M. Lee, Daishu Han, and C. Yan Cheng
Regulation of blood-testis barrier by actin binding proteins and protein kinases, Nan Li, Elizabeth I. Tang, and C. Yan Cheng
Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice, Zhenghui Liu, Shutao Zhao, Qiaoyuan Chen, Keqin Yan, Peng Liu, Nan Li, C. Yan Cheng, Will M. Lee, and Daishu Han
Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells, Xu Li, Cuixia Gao, Yupei Wu, C. Yan Cheng, Weiliang Xia, and Zhiping Zhang
European Society of Contraception statement on contraception in obese women, Gabriele S. Merki-Feld, Sven O. Skouby, David Serfaty, Medard M. Lech, Johannes Bitzer, Pier Giorgio Crosignani, Angelo Cagnacci, and Régine Sitruk-Ware
The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration, Maria Meyer, Maria Claudia Gonzalez Deniselle, Laura Garay, Régine Sitruk-Ware, Rachida Guennoun, Michael Schumacher, and Alejandro De Nicola
rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat Sertoli cells. An in vitro study, Ka-Wai Mok, Haiqi Chen, Will M. Lee, and C. Yan Cheng
The mammalian blood–testis barrier: Its biology and regulation, Dolores D. Mruk and C. Yan Cheng
The Warburg effect revisited—Lesson from the Sertoli cell, Pedro F. Oliveira, Ana D. Martins, Ana C. Moreira, C. Yan Cheng, and Marco G. Alves
Biomedical research at the Population Council, Population Council
Applying emerging science to contraception research: Implications for the clinic, Régine Sitruk-Ware and Anita Nath
Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes, Linlin Su, Yufei Zhang, C. Yan Cheng, Will M. Lee, Keping Ye, and Dahai Hu
EB1 regulates tubulin and actin cytoskeletal networks at the Sertoli cell blood-testis barrier in male rats: An in vitro study, Elizabeth I. Tang, Ka-Wai Mok, Will M. Lee, and C. Yan Cheng
A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Samantha Seidor, Olga Mizenina, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Keith Levendosky, Jessica Kenney, Meropi Aravantinou, Nina Derby, Brooke Grasperge, Agegnehu Gettie, James F. Blanchard, Narender Kumar, Kevin Roberts, Melissa Robbiani, José Fernández-Romero, and Thomas Zydowsky
Submissions from 2014
Biology of spermatogenesis—The challenges ahead, C. Yan Cheng
Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium, C. Yan Cheng and Dolores D. Mruk
Interaction of oligomeric breast cancer resistant protein (BCRP) with adjudin: A male contraceptive with anti-cancer activity, Yan Ho Cheng, Pranitha Jenardhanan, Premendu P. Mathur, Xiaojing Qian, Weiliang Xia, Bruno Silvestrini, and C. Yan Cheng
Thyroid hormone function in the rat testis, Ying Gao, Will M. Lee, and C. Yan Cheng
Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng
New insights into FAK function and regulation during spermatogenesis, N. Ece Gungor-Ordueri, Dolores D. Mruk, Hin Ting Wan, Elissa W.P. Wong, Ciler Celik-Ozenci, Pearl P.Y. Lie, and C. Yan Cheng
Ezrin is an actin binding protein that regulates Sertoli cell and spermatid adhesion during spermatogenesis, N. Ece Gungor-Ordueri, Elizabeth I. Tang, Ciler Celik-Ozenci, and C. Yan Cheng
Sertolin mediates blood-testis barrier restructuring, Michelle W.M. Li, C. Yan Cheng, and Dolores D. Mruk
rpS6 regulates blood–testis barrier dynamics through Akt-mediated effects on MMP-9, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng
Intercellular adhesion molecule 1: Recent findings and new concepts involved in mammalian spermatogenesis, Dolores D. Mruk, Xiang Xiao, Marta Lydka, Michelle W.M. Li, Barbara Bilinska, and C. Yan Cheng
Actin binding proteins, spermatid transport and spermiation, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, Elizabeth I. Tang, Daishu Han, Will M. Lee, Elissa W.P. Wong, and C. Yan Cheng
Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors, Michael Schumacher, Claudia Mattern, Abdel M. Ghoumari, J.P. Oudinet, Florencia Labombarda, Régine Sitruk-Ware, Alejandro De Nicola, and Rachida Guennoun
Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr^407: An in vitro study, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng
Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis, H.T. Wan, Dolores D. Mruk, Elizabeth I. Tang, Xiang Xiao, Yan Ho Cheng, Elissa W.P. Wong, Chris K.C. Wong, and C. Yan Cheng
Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis, Qing Wen, Qiao-Song Zheng, Xi-Xia Li, Zhao-Yuan Hu, Fei Gao, C. Yan Cheng, and Yi-Xun Liu
N-WASP is required for structural integrity of the blood-testis barrier, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, R'ada Massarwa, Ka-Wai Mok, Nan Li, Chris K.C. Wong, Will M. Lee, Scott B. Snapper, Ben-Zion Shilo, Eyal D. Schejter, and C. Yan Cheng
Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Constance M. John, Paul J. Turek, Bruno Silvestrini, and C. Yan Cheng
Germ cell transport across the seminiferous epithelium during spermatogenesis, Xiang Xiao, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng
Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: An in vitro study, Xiang Xiao, Dolores D. Mruk, Elissa W.P. Wong, Will M. Lee, Daishu Han, Chris K.C. Wong, and C. Yan Cheng
Cytokines, polarity proteins, and endosomal protein trafficking and signaling—The Sertoli cell blood–testis barrier system in vitro as a study model, Xiang Xiao, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng
p204-initiated innate antiviral response in mouse Leydig cells, Weiwei Zhu, Peng Liu, Lili Yu, Qiaoyuan Chen, Zhenghui Liu, Keqin Yan, Will M. Lee, C. Yan Cheng, and Daishu Han
Submissions from 2013
Statement on combined hormonal contraceptives containing third- or fourth-generation progestogens or cyproterone acetate, and the associated risk of thromboembolism, Johannes Bitzer, Jean-Jacques Amy, Rob Beerthuizen, Martin Birkhauser, Teresa Bombas, Mitchell Creinin, Philip Darney, Lisa Ferreira Vicente, Kristina Gemzell-Danielsson, Bruno Imthurn, Jeffrey T. Jensen, Andrew M. Kaunitz, Ali Kubba, Medard M. Lech, Diana Mansour, Gabriele Merki, Thomas Rabe, Katrina Sedlecki, David Serfaty, Jacques Seydoux, Lee P. Shulman, Régine Sitruk-Ware, Sven O. Skouby, Anne Szarewski, James Trussell, and Carolyn Westhoff
Contraception orale et risque vasculaire, Philippe Bouchard, Alfred Spira, Yves Ville, Jacqueline Conard, and Régine Sitruk-Ware
Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, and Dolores D. Mruk
Spermatogenesis, Mammals, C. Yan Cheng and Dolores D. Mruk
Why do we need male contraceptives?, C. Yan Cheng and Dolores D. Mruk
The neural androgen receptor: A therapeutic target for myelin repair in chronic demyelination, Rashad Hussain, Abdel M. Ghoumari, Bartosz Bielecki, Jerome Steibel, Nelly Boehm, Philippe Liere, Wendy B. Macklin, Narender Kumar, Rene Habert, Sakina Mhaouty-Kodja, Francois Tronche, Régine Sitruk-Ware, Michael Schumacher, and M. Said Ghandour
New advances on disease biomarkers and molecular targets in biomedicine, Nikki P. Lee, John M. Luk, and C. Yan Cheng
Signalling pathways regulating the blood–testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans, Kun Li, Ya Ni, Yi He, Wen-Ying Chen, Jian-Xin Lu, C. Yan Cheng, Renshan Ge, and Qi-Xian Shi
Gap junctions and blood-tissue barriers, Michelle W.M. Li, Dolores D. Mruk, and C. Yan Cheng
Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis, Stephen Y.T. Li, Dolores D. Mruk, and C. Yan Cheng
Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis, Wing-Yee Lui and C. Yan Cheng
The apical ectoplasmic specialization-blood-testis barrier functional axis is A novel target for male contraception, Ka-Wai Mok, Pearl P.Y. Lie, Dolores D. Mruk, Jayakanthan Mannu, Premendu P. Mathur, Bruno Silvestrini, and C. Yan Cheng
Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the 'yin' and 'yang' effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng
Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary, Shanmugasundaram Nallasamy, Jaeyeon Kim, Régine Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi
Safety and adherence of a non-medicated intravaginal ring (IVR) (MTN-005), Population Council
Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP), Xiao-jing Qian, Yan Ho Cheng, Pranitha Jenardhanan, Dolores D. Mruk, Premendu P. Mathur, Weiliang Xia, Bruno Silvestrini, and C. Yan Cheng
Breast cancer resistance protein (Bcrp) and the testis—An unexpected turn of events, Xiao-jing Qian, Yan Ho Cheng, Dolores D. Mruk, and C. Yan Cheng
Rai14 (Retinoic Acid Induced Protein 14) is involved in regulating F-Actin dynamics at the ectoplasmic specialization in the rat testis, Xiao-jing Qian, Dolores D. Mruk, and C. Yan Cheng
Actin cross-linking protein palladin and spermatogenesis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng
RAI14 (retinoic acid induced protein 14) is an F-actin regulator—Lesson from the testis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng
Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, and C. Yan Cheng
Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, Pearl P.Y. Lie, and C. Yan Cheng
Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone® gels, Mara Y. Roth, Niloufar Ilani, Christina Wang, Stephanie T. Page, William J. Bremner, Ronald S. Swerdloff, Clint Dart, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, and John K. Amory