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Submissions from 2015

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Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activity, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Daishu Han, Will M. Lee, and C. Yan Cheng

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Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Will M. Lee, Daishu Han, and C. Yan Cheng

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Regulation of blood-testis barrier by actin binding proteins and protein kinases, Nan Li, Elizabeth I. Tang, and C. Yan Cheng

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Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice, Zhenghui Liu, Shutao Zhao, Qiaoyuan Chen, Keqin Yan, Peng Liu, Nan Li, C. Yan Cheng, Will M. Lee, and Daishu Han

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Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells, Xu Li, Cuixia Gao, Yupei Wu, C. Yan Cheng, Weiliang Xia, and Zhiping Zhang

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rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat Sertoli cells. An in vitro study, Ka-Wai Mok, Haiqi Chen, Will M. Lee, and C. Yan Cheng

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The mammalian blood–testis barrier: Its biology and regulation, Dolores D. Mruk and C. Yan Cheng

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The Warburg effect revisited—Lesson from the Sertoli cell, Pedro F. Oliveira, Ana D. Martins, Ana C. Moreira, C. Yan Cheng, and Marco G. Alves

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Biomedical research at the Population Council, Population Council

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Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes, Linlin Su, Yufei Zhang, C. Yan Cheng, Will M. Lee, Keping Ye, and Dahai Hu

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EB1 regulates tubulin and actin cytoskeletal networks at the Sertoli cell blood-testis barrier in male rats: An in vitro study, Elizabeth I. Tang, Ka-Wai Mok, Will M. Lee, and C. Yan Cheng

Submissions from 2014

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Biology of spermatogenesis—The challenges ahead, C. Yan Cheng

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Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium, C. Yan Cheng and Dolores D. Mruk

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Thyroid hormone function in the rat testis, Ying Gao, Will M. Lee, and C. Yan Cheng

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Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng

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New insights into FAK function and regulation during spermatogenesis, N. Ece Gungor-Ordueri, Dolores D. Mruk, Hin Ting Wan, Elissa W.P. Wong, Ciler Celik-Ozenci, Pearl P.Y. Lie, and C. Yan Cheng

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Ezrin is an actin binding protein that regulates Sertoli cell and spermatid adhesion during spermatogenesis, N. Ece Gungor-Ordueri, Elizabeth I. Tang, Ciler Celik-Ozenci, and C. Yan Cheng

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Sertolin mediates blood-testis barrier restructuring, Michelle W.M. Li, C. Yan Cheng, and Dolores D. Mruk

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rpS6 regulates blood–testis barrier dynamics through Akt-mediated effects on MMP-9, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng

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Intercellular adhesion molecule 1: Recent findings and new concepts involved in mammalian spermatogenesis, Dolores D. Mruk, Xiang Xiao, Marta Lydka, Michelle W.M. Li, Barbara Bilinska, and C. Yan Cheng

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Actin binding proteins, spermatid transport and spermiation, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, Elizabeth I. Tang, Daishu Han, Will M. Lee, Elissa W.P. Wong, and C. Yan Cheng

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Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors, Michael Schumacher, Claudia Mattern, Abdel M. Ghoumari, J.P. Oudinet, Florencia Labombarda, Régine Sitruk-Ware, Alejandro De Nicola, and Rachida Guennoun

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Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr^407: An in vitro study, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis, H.T. Wan, Dolores D. Mruk, Elizabeth I. Tang, Xiang Xiao, Yan Ho Cheng, Elissa W.P. Wong, Chris K.C. Wong, and C. Yan Cheng

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Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis, Qing Wen, Qiao-Song Zheng, Xi-Xia Li, Zhao-Yuan Hu, Fei Gao, C. Yan Cheng, and Yi-Xun Liu

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N-WASP is required for structural integrity of the blood-testis barrier, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, R'ada Massarwa, Ka-Wai Mok, Nan Li, Chris K.C. Wong, Will M. Lee, Scott B. Snapper, Ben-Zion Shilo, Eyal D. Schejter, and C. Yan Cheng

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Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Constance M. John, Paul J. Turek, Bruno Silvestrini, and C. Yan Cheng

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Germ cell transport across the seminiferous epithelium during spermatogenesis, Xiang Xiao, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: An in vitro study, Xiang Xiao, Dolores D. Mruk, Elissa W.P. Wong, Will M. Lee, Daishu Han, Chris K.C. Wong, and C. Yan Cheng

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Cytokines, polarity proteins, and endosomal protein trafficking and signaling—The Sertoli cell blood–testis barrier system in vitro as a study model, Xiang Xiao, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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p204-initiated innate antiviral response in mouse Leydig cells, Weiwei Zhu, Peng Liu, Lili Yu, Qiaoyuan Chen, Zhenghui Liu, Keqin Yan, Will M. Lee, C. Yan Cheng, and Daishu Han

Submissions from 2013

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Statement on combined hormonal contraceptives containing third- or fourth-generation progestogens or cyproterone acetate, and the associated risk of thromboembolism, Johannes Bitzer, Jean-Jacques Amy, Rob Beerthuizen, Martin Birkhauser, Teresa Bombas, Mitchell Creinin, Philip Darney, Lisa Ferreira Vicente, Kristina Gemzell-Danielsson, Bruno Imthurn, Jeffrey T. Jensen, Andrew M. Kaunitz, Ali Kubba, Medard M. Lech, Diana Mansour, Gabriele Merki, Thomas Rabe, Katrina Sedlecki, David Serfaty, Jacques Seydoux, Lee P. Shulman, Régine Sitruk-Ware, Sven O. Skouby, Anne Szarewski, James Trussell, and Carolyn Westhoff

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Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, and Dolores D. Mruk

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Spermatogenesis, Mammals, C. Yan Cheng and Dolores D. Mruk

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Why do we need male contraceptives?, C. Yan Cheng and Dolores D. Mruk

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Signalling pathways regulating the blood–testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk

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Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans, Kun Li, Ya Ni, Yi He, Wen-Ying Chen, Jian-Xin Lu, C. Yan Cheng, Renshan Ge, and Qi-Xian Shi

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Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis, Stephen Y.T. Li, Dolores D. Mruk, and C. Yan Cheng

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Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the 'yin' and 'yang' effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng

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Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary, Shanmugasundaram Nallasamy, Jaeyeon Kim, Régine Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi

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Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP), Xiao-jing Qian, Yan Ho Cheng, Pranitha Jenardhanan, Dolores D. Mruk, Premendu P. Mathur, Weiliang Xia, Bruno Silvestrini, and C. Yan Cheng

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Breast cancer resistance protein (Bcrp) and the testis—An unexpected turn of events, Xiao-jing Qian, Yan Ho Cheng, Dolores D. Mruk, and C. Yan Cheng

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Rai14 (Retinoic Acid Induced Protein 14) is involved in regulating F-Actin dynamics at the ectoplasmic specialization in the rat testis, Xiao-jing Qian, Dolores D. Mruk, and C. Yan Cheng

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Actin cross-linking protein palladin and spermatogenesis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng

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RAI14 (retinoic acid induced protein 14) is an F-actin regulator—Lesson from the testis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng

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Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, and C. Yan Cheng

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Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, Pearl P.Y. Lie, and C. Yan Cheng

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Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone® gels, Mara Y. Roth, Niloufar Ilani, Christina Wang, Stephanie T. Page, William J. Bremner, Ronald S. Swerdloff, Clint Dart, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, and John K. Amory

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Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation, Jiaxiang Shao, Tengyuan Liu, Qian Reuben Xie, Tingting Zhang, Hemei Yu, Boshi Wang, Weihai Ying, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia

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Progesterone and related progestins: Potential new health benefits, Régine Sitruk-Ware and Martine El-Etr

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Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills, Régine Sitruk-Ware and Anita Nath

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Germ cells contribute to the function of the Sertoli cell barrier: An in vitro study, Linlin Su, Ilona A. Kopera-Sobota, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk

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Regulation of actin dynamics and protein trafficking during spermatogenesis—Insights into a complex process, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng

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MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis, Elizabeth I. Tang and Dolores D. Mruk

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p-FAK-Tyr^397 regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization, Hin Ting Wan, Dolores D. Mruk, Stephen Y.T. Li, Ka-Wai Mok, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Targeting testis-specific proteins to inhibit spermatogenesis: Lesson from endocrine disrupting chemicals, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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The apical ES–BTB–BM functional axis is an emerging target for toxicant-induced infertility, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics, Elissa W.P. Wong and C. Yan Cheng

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Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex, Elissa W.P. Wong, Will M. Lee, and C. Yan Cheng

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Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat, Xiang Xiao, C. Yan Cheng, and Dolores D. Mruk

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c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood–testis barrier axis via its effects on protein recruitment and distribution, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng

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Intercellular adhesion molecules (ICAMs) and spermatogenesis, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng

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Male contraceptive Adjudin is a potential anti-cancer drug, Qian Reuben Xie, Yewei Liu, Jiaxiang Shao, Jian Yang, Tengyuan Liu, Tingting Zhang, Boshi Wang, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia