Submissions from 2010
Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells, Ye-Chen Xiao, Ya-Dong Huang, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Inhibition of 3β- and 17β-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid, Binghai Zhao, Yanhui Chu, Dianne O. Hardy, Xiao-Kun Li, and Renshan Ge
Structure-dependent inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 activities by phthalates, Binghai Zhao, Yanhui Chu, Ya-Dong Huang, Dianne O. Hardy, Shaoqiang Lin, and Renshan Ge
Submissions from 2009
Activins regulate 17β-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells, Beata Bak, Laura Carpio, Jinjing L. Kipp, Pankaj Lamba, Ying Wang, Renshan Ge, Matthew P. Hardy, Kelly E. Mayo, and Daniel J. Bernard
The (+)- and (-)-gossypols potently inhibit human and rat 11β-hydroxysteroid dehydrogenase type 2, Bing-Bing Chen, Han Lin, Guo-Xin Hu, Ying Su, Hong-Yu Zhou, Qing-Quan Lian, Hui Cai, Dianne O. Hardy, Ding-Ying Gu, and Renshan Ge
An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective, C. Yan Cheng and Dolores D. Mruk
Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): An unexpected turn of events, C. Yan Cheng and Dolores D. Mruk
Leydig cells: From stem cells to aging, Haolin Chen, Renshan Ge, and Barry R. Zirkin
Peptidergic not monoaminergic fibers profusely innervate the young adult human testis, Yong-Guang Gong, Ming-Ming Feng, Xiang-Nong Hu, Yi-Qiu Wang, Min Gu, Wei Zhang, and Renshan Ge
Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8-dependent signaling: A novel survival pathway revealed, Yong-Guang Gong, Yi-Qiu Wang, Min Gu, Ming-Ming Feng, Wei Zhang, and Renshan Ge
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11β-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells, Dun Hong, Xing-Wang Li, Qing-Quan Lian, Pankaj Lamba, Daniel J. Bernard, Dianne O. Hardy, Hai-Xiao Chen, and Renshan Ge
Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study, Guo-Xin Hu, Lu-Feng Hu, Dai-Zheng Yang, Jun-Wei Li, Guo-Rong Chen, Bing-Bing Chen, Dolores D. Mruk, Michele Bonanomi, Bruno Silvestrini, C. Yan Cheng, and Renshan Ge
Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence, Guo-Xin Hu, Qing-Quan Lian, Renshan Ge, Dianne O. Hardy, and Xiao-Kun Li
An in vivo study on adjudin and blood-testis barrier dynamics, Ilona A. Kopera, Linlin Su, Barbara Bilínska, C. Yan Cheng, and Dolores D. Mruk
Nitric oxide and cyclic nucleotides: Their roles in junction dynamics and spermatogenesis, Nikki P.Y. Lee and C. Yan Cheng
Testicular cell junction: A novel target for male contraception, Nikki P.Y. Lee, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Value of serum antisperm antibodies in diagnosing obstructive azoospermia, Richard Lee, Marc Goldstein, Brant W. Ullery, Joshua Ehrlich, Marc Soares, Renee A. Razzano, Michael Herman, Mark A. Callahan, Philip S. Li, Peter N. Schlegel, and Steven S. Witkin
A decision analysis of treatments for nonobstructive azoospermia associated with varicocele, Richard Lee, Philip S. Li, Marc Goldstein, Glenn Schattman, and Peter N. Schlegel
Central modifications of allopregnanolone and β-endorphin following subcutaneous administration of Nestorone, E. Lenzi, N. Pluchino, S. Begliuomini, E. Casarosa, S. Merlini, A. Giannini, M. Luisi, Narender Kumar, Régine Sitruk-Ware, and A.R. Genazzani
Coordinating cellular events during spermatogenesis: A biochemical model, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium, Pearl P.Y. Lie, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Mitogen-activated protein kinases in male reproductive function, Michelle W.M. Li, Dolores D. Mruk, and C. Yan Cheng
Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Cytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?, Michelle W.M. Li, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B, Han Lin, Guo-Xin Hu, Lei Dong, Qiang Dong, Motoko Mukai, Bing-Bing Chen, Denise R. Holsberger, Chantal M. Sottas, Paul S. Cooke, Qing-Quan Lian, Xiao-Kun Li, and Renshan Ge
In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats, Han Lin, Qing-Quan Lian, Guo-Xin Hu, Yuan Jin, Yunhui Zhang, Dianne O. Hardy, Guo-Rong Chen, Zhong-Qiu Lu, Chantal M. Sottas, Matthew P. Hardy, and Renshan Ge
Transcription regulation in spermatogenesis, Wing-Yee Lui and C. Yan Cheng
Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men, Vahid Mahabadi, John K. Amory, Ronald S. Swerdloff, William J. Bremner, Stephanie T. Page, Régine Sitruk-Ware, Peter D. Christensen, Narender Kumar, Yun-yen Tsong, Diana Blithe, and Christina Wang
RAB13 participates in ectoplasmic specialization dynamics in the rat testis, Dolores D. Mruk and Ann S.N. Lau
Cadmium-induced testicular injury, Erica R. Siu, Dolores D. Mruk, Catarina S. Porto, and C. Yan Cheng
Focal adhesion kinase is a blood-testis barrier regulator, Erica R. Siu, Elissa W.P. Wong, Dolores D. Mruk, Catarina S. Porto, and C. Yan Cheng
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model, Erica R. Siu, Elissa W.P. Wong, Dolores D. Mruk, K.L. Sze, Catarina S. Porto, and C. Yan Cheng
Extracellular matrix and its role in spermatogenesis, Michelle K.Y. Siu and C. Yan Cheng
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier, Linlin Su, C. Yan Cheng, and Dolores D. Mruk
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis, Shengyi Sun, Elissa W.P. Wong, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng
Normal responses to restraint stress in mice lacking the gene for neuronal nitric oxide synthase, Ben-Avi Weissman, Chantal M. Sottas, Michael Holmes, Ping Zhou, Costantino Iadecola, Dianne O. Hardy, Renshan Ge, and Matthew P. Hardy
Polarity proteins and cell–cell interactions in the testis, Elissa W.P. Wong and C. Yan Cheng
14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes, Elissa W.P. Wong, Shengyi Sun, Michelle W.M. Li, Will M. Lee, and C. Yan Cheng
TGF-β3 and TNFα perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis, Weiliang Xia, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Submissions from 2008
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men, Petrice W. Brown, KeumSil Hwang, Peter N. Schlegel, and Patricia L. Morris
Rapid mechanisms of glucocorticoid signaling in the Leydig cell, Guo-Xin Hu, Qing-Quan Lian, Han Lin, Syed A. Latif, David J. Morris, Matthew P. Hardy, and Renshan Ge
Inhibition of 11β-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in leydig cells, Guo-Xin Hu, Han Lin, Chantal M. Sottas, David J. Morris, Matthew P. Hardy, and Renshan Ge
Cyclic 3′,5′-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm, Gary R. Hunnicutt, Dennis E. Koppel, Susanna Kwitny, and Ann E. Cowan
Adult varicocele, Howard H. Kim and Marc Goldstein
Dynamins, spermatogenesis and contraceptive development, Pearl P.Y. Lie, Dolores D. Mruk, and C. Yan Cheng
"Unlocking" the blood-testis barrier and the ectoplasmic specialization by cytokines during spermatogenesis: Emerging targets for male contraception, Michelle W.M. Li, Dolores D. Mruk, and C. Yan Cheng
Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero, Han Lin, Renshan Ge, Guo-Rong Chen, Guo-Xin Hu, Lei Dong, Qing-Quan Lian, Dianne O. Hardy, Chantal M. Sottas, Xiao-Kun Li, and Matthew P. Hardy
Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis, Peter Y. Liu, Ronald S. Swerdloff, Bradley D. Anawalt, Richard A. Anderson, William J. Bremner, Joerg Elliesen, Yi-Qun Gu, Wendy M. Kersemaekers, Robert I. McLachlan, M. Cristina Meriggiola, Eberhard Nieschlag, Régine Sitruk-Ware, Kirsten M. Vogelsong, Xing-Hai Wang, Frederick C.W. Wu, Michael Zitzmann, David J. Handelsman, and Christina Wang
Anchoring junctions as drug targets: Role in contraceptive development, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng
Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2, Thomas M. Onorato, Petrice W. Brown, and Patricia L. Morris
Interleukin 1 alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat, Oli Sarkar, Premendu P. Mathur, C. Yan Cheng, and Dolores D. Mruk
Nitric oxide-cGMP signaling: Its role in cell junction dynamics during spermatogenesis, Oli Sarkar, Premendu P. Mathur, and Dolores D. Mruk
Progesterone and progestins: Neuroprotection and myelin repair, Michael Schumacher, Régine Sitruk-Ware, and Alejandro De Nicola
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Delivery of contraceptives to men: Lesson from other therapeutic drugs, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng
Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis, Elissa W.P. Wong, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells, Helen H.N. Yan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Cross-talk between tight and anchoring junctions: Lesson from the testis, Helen H.N. Yan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis, Helen H.N. Yan, Dolores D. Mruk, Elissa W.P. Wong, Will M. Lee, and C. Yan Cheng
Submissions from 2007
Effect of a single vaginal administration of levonorgestrel in Carraguard® gel on the ovulatory process: A potential candidate for "dual protection" emergency contraception, Vivian Brache, Horacio B. Croxatto, Régine Sitruk-Ware, Robin A. Maguire, Juan Carlos Montero, Narender Kumar, Ana Maria Salvatierra, Ana Sofia Tejada, Leila Cochon, María Luisa Forcelledo, Pekka Lahteenmaki, Francisco Alvarez, and Anibal Faundes
Development of a cryopreservation protocol for Leydig cells, Guo-Rong Chen, Renshan Ge, Han Lin, Lei Dong, Chantal M. Sottas, and Matthew P. Hardy
Gene expression during development of fetal and adult Leydig cells, Lei Dong, Scott A. Jelinsky, Joshua N. Finger, Daniel S. Johnston, Gregory S. Kopf, Chantal M. Sottas, Matthew P. Hardy, and Renshan Ge
An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive, Ian S. Fraser, Edith Weisberg, Narender Kumar, Sushma Kumar, Andrew J. Humberstone, Louise McCrossin, Deborah Shaw, Yun-yen Tsong, and Régine Sitruk-Ware
Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats, Renshan Ge, Guo-Rong Chen, Qiang Dong, Benson T. Akingbemi, Chantal M. Sottas, Michelle Santos, Stuart C. Sealfon, Daniel J. Bernard, and Matthew P. Hardy
Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations, Renshan Ge, Guo-Rong Chen, Cigdem Tanrikut, and Matthew P. Hardy
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes, Nikki P.Y. Lee, Dolores D. Mruk, Weiliang Xia, and C. Yan Cheng
Regulation of cell junction dynamics by cytokines in the testis—A molecular and biochemical perspective, Wing Yee Lui and C. Yan Cheng
Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas, Takeshi Maruo, Noriyuki Ohara, Hiroya Matsuo, Qin Xu, Wei Chen, Régine Sitruk-Ware, and Elof D.B. Johansson
Rab4A GTPase-catenin interactions are involved in cell junction dynamics in the testis, Dolores D. Mruk, Ann S.N. Lau, Oli Sarkar, and Weiliang Xia
GM1 dynamics as a marker for membrane changes associated with the process of capacitation in murine and bovine spermatozoa, Vimal Selvaraj, Danielle E. Buttke, Atsushi Asano, John L. McElwee, Collin A. Wolff, Jacquelyn L. Nelson, Angela V. Klaus, Gary R. Hunnicutt, and Alexander J. Travis
Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys, Carol A. Shively, Charles E. Wood, Thomas C. Register, Stephanie L. Willard, Cynthia J. Lees, Haiying Chen, Régine Sitruk-Ware, Yun-yen Tsong, and J. Mark Cline
New hormonal therapies and regimens in the postmenopause: Routes of administration and timing of initiation, Régine Sitruk-Ware
7α-methyl-19-nortestosterone (MENT) vs testosterone in combination with etonogestrel implants for spermatogenic suppression in healthy men, Melanie J. Walton, Narender Kumar, David T. Baird, Helen Ludlow, and Richard A. Anderson
A seamless trespass: Germ cell migration across the seminiferous epithelium during spermatogenesis, Claire Q.F. Wang and C. Yan Cheng
Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface, Claire Q.F. Wang, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress, Ben-Avi Weissman, Chantal M. Sottas, Ping Zhou, Costantino Iadecola, and Matthew P. Hardy
C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes, Weiliang Xia, Dolores D. Mruk, and C. Yan Cheng
Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model, Weiliang Xia, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development, Helen H.N. Yan, Dolores D. Mruk, and C. Yan Cheng
Ectoplasmic specialization: A friend or a foe of spermatogenesis?, Helen H.N. Yan, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Submissions from 2006
A novel class of small RNAs bind to MILI protein in mouse testes, Alexei Aravin, Dimos Gaidatzis, Sebastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia L. Morris, Michael J. Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano, Minchen Chien, James J. Russo, Jingyue Ju, Robert Sheridan, Chris Sander, Mihaela Zavolan, and Thomas Tuschl
Visualization of GM1 with cholera toxin B in live epididymal versus ejaculated bull, mouse, and human spermatozoa, Danielle E. Buttke, Jacquelyn L. Nelson, Peter N. Schlegel, Gary R. Hunnicutt, and Alexander J. Travis
In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development, Renshan Ge, Qiang Dong, Chantal M. Sottas, Vassilios Papadopoulos, Barry R. Zirkin, and Matthew P. Hardy
A multistep kinase-based Sertoli cell autocrine-amplifying loop regulates prostaglandins, their receptors, and cytokines, Tomomoto Ishikawa and Patricia L. Morris
Interleukin-1β signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in sertoli epithelial cells, Tomomoto Ishikawa and Patricia L. Morris
Dynamic II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes, Pearl P.Y. Lie, Weiliang Xia, Claire Q.F. Wang, Dolores D. Mruk, Helen H.N. Yan, Ching-hang Wong, Will M. Lee, and C. Yan Cheng
Tumor necrosis factor α reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes, Michelle W.M. Li, Weiliang Xia, Dolores D. Mruk, Claire Q.F. Wang, Helen H.N. Yan, Michelle K.Y. Siu, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng
A male contraceptive targeting germ cell adhesion, Dolores D. Mruk, Ching-hang Wong, Bruno Silvestrini, and C. Yan Cheng
A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice, Gopinath S. Palanisamy, Yong-Pil Cheon, Jaeyeon Kim, Athilakshmi Kannan, Quanxi Li, Marcey Sato, Srinivasa R. Mantena, Régine Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions, Oli Sarkar, Weiliang Xia, and Dolores D. Mruk
SUMO-1, human male germ cell development, and the androgen receptor in the testis of men with normal and abnormal spermatogenesis, Margarita Vigodner, Tomomoto Ishikawa, Peter N. Schlegel, and Patricia L. Morris
The sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin, Katja M. Wolski, Dolores D. Mruk, and Don F. Cameron
Differential interactions between transforming growth factor-β3/ TβR1, TAB1, and CD2AP disrupt blood-testis barrier and sertoli-germ cell adhesion, Weiliang Xia, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng
Laminin α3 forms a complex with β3 and γ3 chains that serves as the ligand for α6β1-integrin at the apical ectoplasmic specialization in adult rat testes, Helen H.N. Yan and C. Yan Cheng
Submissions from 2005
Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID, Allison E. Falender, Richard N. Freiman, Kenneth G. Geles, Kirk C. Lo, KeumSil Hwang, Dolores J. Lamb, Patricia L. Morris, Robert Tjian, and JoAnne S. Richards
11β-hydroxysteroid dehydrogenase 2 in rat leydig cells: Its role in blunting glucocorticoid action at physiological levels of substrate, Renshan Ge, Qiang Dong, Enmei Niu, Chantal M. Sottas, Dianne O. Hardy, James F. Catterall, Syed A. Latif, David J. Morris, and Matthew P. Hardy
Gene expression in rat leydig cells during development from the progenitor to adult stage: A cluster analysis, Renshan Ge, Qiang Dong, Chantal M. Sottas, Haolin Chen, Barry R. Zirkin, and Matthew P. Hardy
Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated, Renshan Ge, Qiang Dong, Chantal M. Sottas, Syed A. Latif, David J. Morris, and Matthew P. Hardy
Stress hormone and male reproductive function, Matthew P. Hardy, Hui-Bao Gao, Qiang Dong, Renshan Ge, Qian Wang, Wei Ran Chai, Xing Feng, and Chantal M. Sottas