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Submissions from 2023

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Development of mucoadhesive electrospun scaffolds for intravaginal delivery of Lactobacilli spp., a tenside, and metronidazole for the management of bacterial vaginosis, Margaret O. Ilomuanya, Peace O. Bassey, Deborah A. Ogundemuren, Uloma N. Ubani-Ukoma, Alkiviadis Tsamis, Yuwei Fan, Konstantinos Michalakis, Pavimol Angsantikul, Abdulrahman Usman, and Andrew N. Amenaghawon

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New approaches for developing biomarkers of hormonal contraceptive use, Rakhee Sachdeva, Narender Kumar, Vivian Brache, Barbara Friedland, Marlena Gehret Plagianos, Shimin Zhang, Larisa Kizima, Leila Cochon, Ana Sofía Tejada Tabar, Ann K. Blanc, and Ruth Merkatz

Submissions from 2022

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Exposed and sequestered antigens in testes and their protection by regulatory T cell-dependent systemic tolerance, Jessica Harakal, Hui Qiao, Karen Wheeler, Claudia Rival, Alberta G.A. Paul, Daniel M. Hardy, C. Yan Cheng, Erwin Goldberg, and Kenneth S.K. Tung

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mTORC1/rpS6 and p-FAK-Y407 signaling regulate spermatogenesis: Insights from studies of the adjudin pharmaceutical/toxicant model, Lingling Wang, Linxi Li, Xiaolong Wu, Chris K.C. Wong, Adolfo Perrotta, Bruno Silvestrini, Fei Sun, and C. Yan Cheng

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Role of laminin and collagen chains in human spermatogenesis—Insights from studies in rodents and scRNA-Seq transcriptome profiling, Xiaolong Wu, Sheng Gao, Lingling Wang, Tiao Bu, Siwen Wu, Liwei Zhou, Jie Shi, Di Wu, Fei Sun, and C. Yan Cheng

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Trichomonas vaginalis and spontaneous preterm birth in a high-risk obstetric cohort in Atlanta, GA, Marisa R. Young, Kristin M. Wall, Carolynn M. Dude, Emily R. Burdette, Denise J. Jamieson, Igho Ofotokun, and Lisa Haddad

Submissions from 2021

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Dissecting mammalian spermatogenesis using spatial transcriptomics, Haiqi Chen, Evan Murray, Anubhav Sinha, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley R. Cairns, Evan Z. Macosko, C. Yan Cheng, and Fei Chen

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A local regulatory network in the testis mediated by laminin and collagen fragments that supports spermatogenesis, Linxi Li, Huitao Li, Lingling Wang, Tiao Bu, Shiwen Liu, Baiping Mao, and C. Yan Cheng

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NC1-peptide derived from collagen α3 (IV) chain is a blood-tissue barrier regulator: Lesson from the testis, Shiwen Liu, Huitao Li, Renshan Ge, and C. Yan Cheng

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Tex13a optimizes sperm motility via its potential roles in mRNA turnover, Yinchuan Li, Panpan Mi, Xue Chen, Jiabao Wu, Xiaohua Liu, Yunge Tang, Jinmei Cheng, Yingying Huang, Weibing Qin, and C. Yan Cheng

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Dynamic profiles and transcriptional preferences of histone modifications during spermiogenesis, Yinchuan Li, Panpan Mi, Xue Chen, Jiabao Wu, Weibing Qin, Yiqi Shen, Pingbao Zhang, Yunge Tang, C. Yan Cheng, and Fei Sun

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The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407, Lingling Wang, Ming Yan, Huitao Li, Siwen Wu, Renshan Ge, Chris K.C. Wong, Bruno Silvestrini, Fei Sun, and C. Yan Cheng

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Microtubule-associated proteins (MAPs) in microtubule cytoskeletal dynamics and spermatogenesis, Lingling Wang, Ming Yan, Chris K.C. Wong, Renshan Ge, Xiaolong Wu, Fei Sun, and C. Yan Cheng

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Motor proteins and spermatogenesis, Siwen Wu, Huitao Li, Lingling Wang, Nathan Mak, Xiaolong Wu, Renshan Ge, Fei Sun, and C. Yan Cheng

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AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis, Siwen Wu, Linxi Li, Xiaolong Wu, Chris K.C. Wong, Fei Sun, and C. Yan Cheng

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KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin and septin cytoskeletons, Siwen Wu, Lixiu Lv, Linxi Li, Lingling Wang, Baiping Mao, Jun Li, Xian Shen, Renshan Ge, Chris K.C. Wong, Fei Sun, and C. Yan Cheng

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An in vitro assay to monitor sertoli cell blood-testis barrier (BTB) integrity, Siwen Wu, Lingling Wang, Elizabeth I. Tang, Junlu Wang, and C. Yan Cheng

Submissions from 2020

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407, Huitao Li, Shiwen Liu, Siwen Wu, Renshan Ge, and C. Yan Cheng

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Bioactive fragments of laminin and collagen chains—Lesson from the testis, Huitao Li, Shiwen Liu, Siwen Wu, Linxi Li, Renshan Ge, and C. Yan Cheng

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Role of cell polarity and planar cell polarity (PCP) proteins in spermatogenesis, Linxi Li, Huitao Li, Lingling Wang, Siwen Wu, Lixiu Lv, Anam Tahir, Xiang Xiao, Chris K.C. Wong, Fei Sun, and C. Yan Cheng

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Endogenously produced LG3/4/5-peptide protects testes against toxicant-induced injury, Linxi Li, Baiping Mao, Siwen Wu, Huitao Li, Lixiu Lv, Renshan Ge, and C. Yan Cheng

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NC1‐peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1, Shiwen Liu, Huitao Li, Siwen Wu, Linxi Li, Renshan Ge, and C. Yan Cheng

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Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis, Zhengyu Luo, Xiaorong Wang, Hong Jiang, Ruoyu Wang, Jian Chen, Yusheng Chen, Qianlan Xu, Jun Cao, Xiaowen Gong, Ji Wu, Yungui Yang, Wenbo Li, Chunsheng Han, C. Yan Cheng, Michael G. Rosenfeld, Fei Sun, and Xiaoyuan Song

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Role of microtubule +TIPs and -TIPs in spermatogenesis—Insights from studies of toxicant models, Baiping Mao, Renshan Ge, and C. Yan Cheng

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Testin regulates the blood‐testis barrier via disturbing occludin/ZO‐1 association and actin organization, Linlin Su, Zhaohua Wang, Songtao Xie, Dahai Hu, C. Yan Cheng, Dolores D. Mruk, and Yongjun Guan

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Microtubule cytoskeleton and spermatogenesis—Lesson from studies of toxicant models, Lingling Wang, Ming Yan, Siwen Wu, Baiping Mao, Chris K.C. Wong, Renshan Ge, Fei Sun, and C. Yan Cheng

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Actin binding proteins, actin cytoskeleton and spermatogenesis—Lesson from toxicant models, Lingling Wang, Ming Yan, Siwen Wu, Xiaolong Wu, Tiao Bu, Chris K.C. Wong, Renshan Ge, Fei Sun, and C. Yan Cheng

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An exploration of the role of Sertoli cells on fetal testis development using cell ablation strategy, Yu-Qian Wang, Jin-Mei Cheng, Qing Wen, Ji-Xin Tang, Jian Li, Su-Ren Chen, and Yi-Xun Liu

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Crosstalk between Sertoli and germ cells in male fertility, Siwen Wu, Ming Yan, Renshan Ge, and C. Yan Cheng

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Unraveling epigenomic abnormality in azoospermic human males by WGBS, RNA-Seq, and transcriptome profiling analyses, Xiaolong Wu, Chunhai Luo, Longfei Hu, Xue Chen, Yunmei Chen, Jue Fan, C. Yan Cheng, and Fei Sun

Submissions from 2019

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Combined Nestorone–testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men, Bradley D. Anawalt, Mara Y. Roth, Jonas Ceponis, Vijaya Surampadi, John K. Amory, Ronald S. Swerdloff, Peter Y. Liu, Clint Dart, William J. Bremner, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, Stephanie T. Page, and Christina Wang

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Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: Results of two multicentre, open-label, single-arm, phase 3 trials, David F. Archer, Ruth Merkatz, Luis Bahamondes, Carolyn Westhoff, Philip Darney, Dan Apter, Jeffrey T. Jensen, Vivian Brache, Anita L. Nelson, Erika Banks, György Bártfai, David J. Portman, Marlena Gehret Plagianos, Clint Dart, Narender Kumar, George W. Creasy, Régine Sitruk-Ware, and Diana Blithe

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Mucosal susceptibility to human immunodeficiency virus infection in the proliferative and secretory phases of the menstrual cycle, Giulia Calenda, Guillermo Villegas, Alexandra Reis, Lily Millen, Patrick Barnable, Lisa Mamkina, Narender Kumar, Kevin Roberts, Tamara Kalir, Elena Martinelli, Rhoda Sperling, and Natalia Teleshova

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F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin, Haiqi Chen, Dolores D. Mruk, Chris K.C. Wong, Bruno Silvestrini, and C. Yan Cheng

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Segesterone acetate/ethinyl estradiol 12-month contraceptive vaginal system safety evaluation, Kristina Gemzell-Danielsson, Régine Sitruk-Ware, Mitchell Creinin, Michael Thomas, Kurt T. Barnhart, George W. Creasy, Heather Sussman, Mohcine Alami, Anne E. Burke, Edith Weisberg, Ian S. Fraser, Marie-José Miranda, Melissa Gilliam, James Liu, Bruce R. Carr, Marlena Gehret Plagianos, Kevin Roberts, and Diana Blithe

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Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization, Linxi Li, Baiping Mao, Ming Yan, Siwen Wu, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro study, Linxi Li, Siwen Wu, Ming Yan, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

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CAMSAP2 is a microtubule minus-end targeting protein (-TIP) that regulates BTB dynamics through cytoskeletal organization, Baiping Mao, Linxi Li, Renshan Ge, Chao Li, Chris K.C. Wong, Bruno Silvestrini, Qing-Quan Lian, and C. Yan Cheng

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Regulation of BTB dynamics in spermatogenesis—Insights from the adjudin model, Baiping Mao, Linxi Li, Ming Yan, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis—Lesson from the adjudin model, Baiping Mao, Linxi Li, Ming Yan, Chris K.C. Wong, Bruno Silvestrini, Chao Li, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Efficacy and safety of a 1-year segesterone acetate and ethinyl estradiol contraceptive vaginal system, Ruth Merkatz, Maureen Magnani, Heather Sussman, George W. Creasy, and Régine Sitruk-Ware

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Comparative transcriptome analysis of the human endocervix and ectocervix during the proliferative and secretory phases of the menstrual cycle, Sampurna Mukhopadhyay, Y. Liang, H. Hur, Guillermo Villegas, Giulia Calenda, Alexandra Reis, Lily Millen, Patrick Barnable, Lisa Mamkina, Narender Kumar, Tamara Kalir, Rhoda Sperling, and Natalia Teleshova

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Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization, Wenhui Su and C. Yan Cheng

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Bone turnover markers in women participating in a dose-finding trial of a contraceptive vaginal ring releasing Nestorone and estradiol, Molly Tiedeken, Carolyn Westhoff, Adi Cohen, Serge Cremers, Régine Sitruk-Ware, Diana Blithe, and The NICHD Contraceptive Trials Network Vaginal Ring Group

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Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic, Julian P. Tuazon, Régine Sitruk-Ware, and Cesario V. Borlongan

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Bleeding profile associated with 1-year use of the segesterone acetate/ethinyl estradiol contraceptive vaginal system: Pooled analysis from phase 3 trials, Carolina Sales Vieira, Ian S. Fraser, Marlena Gehret Plagianos, Anne E. Burke, Carolyn Westhoff, Jeffrey T. Jensen, Vivian Brache, Luis Bahamondes, Ruth Merkatz, Régine Sitruk-Ware, and Diana Blithe

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Kruppel-like factor 6 regulates Sertoli cell blood-testis barrier, Xiu-Xia Wang, Yan Zhang, Xiao-Yu Li, Jian Li, Ji-Xin Tang, Yuan-Yuan Li, Shou-Long Deng, C. Yan Cheng, and Yi-Xun Liu

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Myosin VIIa supports spermatid/organelle transport and cell adhesion during spermatogenesis in the rat testis, Qing Wen, Siwen Wu, Will M. Lee, Chris K.C. Wong, Wing-Yee Lui, Bruno Silvestrini, and C. Yan Cheng

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mTORC1/rpS6 and spermatogenic function in the testis—Insights from the adjudin model, Siwen Wu, Ming Yan, Linxi Li, Baiping Mao, Chris K.C. Wong, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Emerging role for SRC family kinases in junction dynamics during spermatogenesis, Xiang Xiao, Yue Yang, Baiping Mao, C. Yan Cheng, and Ya Ni

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mTORC1/rpS6 signaling complex that modifies BTB transport function—An in vivo study using the adjudin model, Ming Yan, Linxi Li, Baiping Mao, Huitao Li, Stephen Y.T. Li, Dolores D. Mruk, Bruno Silvestrini, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

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Preventing secondary exposure to women from men applying a novel Nestorone/testosterone contraceptive gel, F. Yuen, S. Wu, A. Thirumalai, Ronald S. Swerdloff, Stephanie T. Page, Peter Y. Liu, Clint Dart, H. Wu, Diana Blithe, Régine Sitruk-Ware, J. Long, F. Bai, L. Hull, William J. Bremner, Bradley D. Anawalt, and Christina Wang

Submissions from 2018

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A germline-specific role for the mTORC2 component Rictor in maintaining spermatogonial differentiation and intercellular adhesion in mouse testis, Shun Bai, Le Cheng, Yingwen Zhang, Chunsen Zhu, Zhiping Zhu, Ruping Zhu, C. Yan Cheng, Lan Ye, and Ke Zheng

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Simplifying the ShangRing technique for circumcision in boys and men: Use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment, Mark Barone, Philip S. Li, Richard K. Lee, Daniel Ouma, Millicent Oundo, Mukhaye Barasa, Jairus Oketch, Patrick Otiende, Nixon Nyangweso, Mary N. Maina, Nicholas Kiswi, Betty Chirchir, Marc Goldstein, and Quentin Awori

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Safety of tubal occlusion by minilaparotomy provided by trained clinical officers versus assistant medical officers in Tanzania: A randomized, controlled, noninferiority trial, Mark Barone, Zuhura Mbuguni, Japhet Ominde Achola, Annette Almeida, Carmela Cordero, Joseph Kanama, Adriana Marquina, Projestine Muganyizi, Jamilla Mwanga, Daniel Ouma, Caitlin S. Shannon, and Leopold Tibyehabwa

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Monitoring the integrity of the blood-testis barrier (BTB): An in vivo assay, Haiqi Chen, Wing-Yee Lui, Dolores D. Mruk, Xiang Xiao, Renshan Ge, Qing-Quan Lian, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Cell polarity and planar cell polarity (PCP) in spermatogenesis, Haiqi Chen, Dolores D. Mruk, Wing-Yee Lui, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng

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Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Therapeutic progestin segesterone acetate promotes neurogenesis: Implications for sustaining regeneration in female brain, Shuhua Chen, Narender Kumar, Zisu Mao, Régine Sitruk-Ware, and Roberta Diaz Brinton

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Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: Updated indirect comparison meta-analysis, Agustin Conde-Agudelo, Roberto Romero, Eduardo Da Fonseca, John M. O'Brien, Elcin Cetingoz, George W. Creasy, Sonia S. Hassan, Offer Erez, Percy Pacora, and Kypros H. Nicolaides

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Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells, Shou-Long Deng, Zhi-Peng Wang, Cheng Jin, Xiao-Long Kang, Alia Batool, Yan Zhang, Xiao-Yu Li, Xiu-Xia Wang, Su-Ren Chen, Chawn-Shang Chang, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu

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Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects, Alejandro De Nicola, Laura Garay, Maria Meyer, Rachida Guennoun, Régine Sitruk-Ware, Michael Schumacher, and Maria Claudia Gonzalez Deniselle

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SUMOylation regulates germinal vesicle break-down and the AKT/PKB pathway during mouse oocyte maturation, Weber Beringui Feitosa and Patricia L. Morris

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Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone® and estradiol: Pharmacokinetics from a dose-finding study, Jeffrey T. Jensen, Alison E. Edelman, Beatrice A. Chen, D.F. Archer, Kurt T. Barnhart, M.A. Thomas, Anne E. Burke, Carolyn Westhoff, Livia Wan, Régine Sitruk-Ware, Narender Kumar, Bruce Variano, and Diana Blithe

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Characterization of molecular changes in endometrium associated with chronic use of progesterone receptor modulators: Ulipristal acetate versus mifepristone, Athilakshmi Kannan, A. Bhurke, Régine Sitruk-Ware, P.G. Lalitkumar, Kristina Gemzell-Danielsson, A. Williams, R.N. Taylor, Milan K. Bagchi, and Indrani C. Bagchi

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mTORC1/rpS6 regulates blood-testis barrier (BTB) dynamics and spermatogenetic function in the testis in vivo, Stephen Y.T. Li, Ming Yan, Haiqi Chen, Tito T. Jesus, Will M. Lee, Xiang Xiao, and C. Yan Cheng

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Regulation of blood–testis barrier assembly in vivo by germ cells, Xiao-Yu Li, Yan Zhang, Xiu-Xia Wang, Cheng Jin, Yu-Qian Wang, Tie-Cheng Sun, Ji-Xin Tang, Alia Batool, Shou-Long Deng, Su-Ren Chen, C. Yan Cheng, and Yi-Xun Liu

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Mechanistic insights into PFOS-mediated Sertoli cell injury, Baiping Mao, Dolores D. Mruk, Qing-Quan Lian, Renshan Ge, Chao Li, Bruno Silvestrini, and C. Yan Cheng

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Male germ cells support long-term propagation of Zika virus, Christopher L. Robinson, Angie C.N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel, and Shuibing Chen

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Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: A randomized, crossover drug–drug interaction study, Katharine B. Simmons, Narender Kumar, Marlena Gehret Plagianos, Kevin Roberts, Elena Hoskin, Leo Han, Mohcine Alami, George W. Creasy, Bruce Variano, and Ruth Merkatz

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Non-clinical studies of progesterone, Régine Sitruk-Ware

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Factors associated with non-adherence to instructions for using the Nestorone®/ethinyl estradiol contraceptive vaginal ring, Bianca M. Stifani, Marlena Gehret Plagianos, Carolina Sales Vieira, and Ruth Merkatz

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Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis, Qing Wen, Nan Li, Xiang Xiao, Wing-Yee Lui, Darren S. Chu, Chris K.C. Wong, Qing-Quan Lian, Renshan Ge, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Cell polarity and cytoskeletons—Lesson from the testis, Qing Wen, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Wing-Yee Lui, Will M. Lee, Xiang Xiao, Bruno Silvestrini, and C. Yan Cheng

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Signaling pathways regulating blood-tissue barriers—Lesson from the testis, Qing Wen, Elizabeth I. Tang, Ying Gao, Tito T. Jesus, Darren S. Chu, Will M. Lee, Chris K.C. Wong, Yi-Xun Liu, Xiang Xiao, Bruno Silvestrini, and C. Yan Cheng

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Advances in our understanding of human spermatogenesis, Qing Wen, Elizabeth I. Tang, Tito T. Jesus, Bruno Silvestrini, and C. Yan Cheng

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Regulation of blood-testis barrier (BTB) dynamics, role of actin-, and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Nan Li, Dolores D. Mruk, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Cell junctions in the testis as targets for toxicants, Elissa W.P. Wong, Helen H.N. Yan, Michelle W.M. Li, Pearl P.Y. Lie, Dolores D. Mruk, and C. Yan Cheng

Submissions from 2017

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A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques, Meropi Aravantinou, Ines Frank, Geraldine Arrode-Bruses, Moriah Szpara, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Nina Derby, and Elena Martinelli

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Adjudin—A male contraceptive with anti-cancer, anti-neuroinflammation and anti-ototoxicity activities, Yan Ho Cheng, Weiliang Xia, Xiang Xiao, Elizabeth I. Tang, Haiqi Chen, Qing Wen, Ying Gao, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

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Focal adhesion kinase (FAK), Haiqi Chen and C. Yan Cheng

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Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant, Haiqi Chen, Ying Gao, Dolores D. Mruk, and C. Yan Cheng

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Drebrin and spermatogenesis, Haiqi Chen, Michelle W.M. Li, and C. Yan Cheng

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Regulation of spermatogenesis by a local functional axis in the testis: Role of the basement membrane–derived noncollagenous 1 domain peptide, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Human spermatogenesis and its regulation, Haiqi Chen, Dolores D. Mruk, Xiang Xiao, and C. Yan Cheng

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Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk

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Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system, Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu

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Basement membrane laminin α2 regulates BTB dynamics via its effects on F-actin- and microtubule (MT)-cytoskeletons via mTORC1 signaling, Ying Gao, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2, Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng

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Regulation of the blood–testis barrier by a local axis in the testis: Role of laminin α2 in the basement membrane, Ying Gao, Dolores D. Mruk, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Mammalian target of rapamycin (mTOR): A central regulator of male fertility?, Tito T. Jesus, Pedro F. Oliveira, Mario Sousa, C. Yan Cheng, and Marco G. Alves

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Nestorone® (NES) a novel progestin for non-oral contraception: Structure-activity relationships and brain metabolism studies, Narender Kumar, Jerome Fagart, Philippe Liere, Scott J. Mitchell, Alanah R. Knibb, Isabelle Petit-Topin, Marion Rame, Martine El-Etr, Michael Schumacher, Jeremy J. Lambert, Marie-Edith Rafestin-Oblin, and Régine Sitruk-Ware

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Cell polarity, cell adhesion, and spermatogenesis: Role of cytoskeletons, Linxi Li, Ying Gao, Haiqi Chen, Tito T. Jesus, Elizabeth I. Tang, Nan Li, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

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Sperm release at spermiation is regulated by changes in the organization of actin- and microtubule-based cytoskeletons at the apical ectoplasmic specialization—A study using the adjudin model, Linxi Li, Elizabeth I. Tang, Haiqi Chen, Qing-Quan Lian, Renshan Ge, Bruno Silvestrini, and C. Yan Cheng

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Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with α-catenin at the blood–testis barrier, Dolores D. Mruk, Michele Bonanomi, and Bruno Silvestrini

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Emerging role for mammalian target of rapamycin in male fertility, Pedro F. Oliveira, C. Yan Cheng, and Marco G. Alves

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Abcb1a and Abcb1b genes function differentially in blood–testis barrier dynamics in the rat, Linlin Su, C. Yan Cheng, Will M. Lee, Min Zhang, Fangfang Yang, Bin Zhao, Daishu Han, Yixun Liu, and Dahai Hu

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MAP/Microtubule affinity-regulating kinase, Elizabeth I. Tang and C. Yan Cheng

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Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance, Kenneth S.K. Tung, Jessica Harakal, Hui Qiao, Claudia Rival, Jonathan C.H. Li, Alberta G.A. Paul, Karen Wheeler, Patcharin Pramoonjago, Constance M. Grafer, Wei Sun, Robert D. Sampson, Elissa W.P. Wong, Prabhakara P. Reddi, Umesh S. Deshmukh, Daniel M. Hardy, Huanghui Tang, C. Yan Cheng, and Erwin Goldberg

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Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: A randomized clinical trial, Michael Zitzmann, Julia Rohayem, J. Raidt, Sabine Kliesch, Narender Kumar, and Régine Sitruk-Ware