Mitogen-activated protein kinases in male reproductive function
Document Type
Article (peer-reviewed)
Publication Date
2009
Abstract
Recent studies have shown that male reproductive function is modulated via the mitogen-activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male reproductive processes, including spermatogenesis, sperm maturation and activation, capacitation and acrosome reaction, before fertilization of the oocyte. In this review, we discuss the latest findings in this rapidly developing field regarding the role of MAPK in male reproduction in animal models and in human spermatozoa in vitro. This research will facilitate the design of future studies in humans, although much work is needed before this information can be used to manage male infertility and environmental toxicant-induced testicular injury in men, such as blood-testis-barrier disruption.
Recommended Citation
Li, Michelle W.M., Dolores D. Mruk, and C. Yan Cheng. 2009. "Mitogen-activated protein kinases in male reproductive function," Trends in Molecular Medicine 15(4): 159–168.
DOI
10.1016/j.molmed.2009.02.002
Language
English
Project
Probing Studies in Male Contraception
https://doi.org/10.1016/j.molmed.2009.02.002