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Submissions from 2016

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Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis, Elizabeth I. Tang, Dolores D. Mruk, and C. Yan Cheng

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AKAP9, a regulator of microtubule dynamics, contributes to blood-testis barrier function, Deepak Venkatesh, Dolores D. Mruk, Jan M. Herter, Xavier Cullere, Katarzyna Chojnacka, C. Yan Cheng, and Tanya N. Mayadas

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Development, function and fate of fetal Leydig cells, Qing Wen, C. Yan Cheng, and Yi-Xun Liu

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Transport of germ cells across the seminiferous epithelium during spermatogenesis—The involvement of both actin- and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Xiang Xiao, Ying Gao, Darren S. Chu, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

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Sertoli cell Wt1 regulates peritubular myoid cell and fetal leydig cell differentiation during fetal testis development, Qing Wen, Yuqian Wang, Ji-Xin Tang, C. Yan Cheng, and Yi-Xun Liu

Submissions from 2015

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Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model, C. Yan Cheng

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Adjudin – A male contraceptive with other biological activities, Yan Ho Cheng, Weiliang Xia, Elissa W.P. Wong, Qian Reuben Xie, Jiaxiang Shao, Tengyuan Liu, Yizhou Quan, Tingting Zhang, Xiao Yang, Keyi Geng, Bruno Silvestrini, and C. Yan Cheng

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Sertoli cells are the target of environmental toxicants in the testis—A mechanistic and therapeutic insight, Ying Gao, Dolores D. Mruk, and C. Yan Cheng

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Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection, Natalia Guerra-Perez, Ines Frank, Filippo Veglia, Meropi Aravantinou, Diana J. Goode, James L. Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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Ezrin: A regulator of actin microfilaments in cell junctions of the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng

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Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics, N. Ece Gungor-Ordueri and C. Yan Cheng

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Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction, Nan Li, Zhenghui Liu, Yue Zhang, Qiaoyuan Chen, C. Yan Cheng, Will M. Lee, Yong-Mei Chen, and Daishu Han

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Actin binding proteins in blood–testis barrier function, Nan Li, Dolores D. Mruk, and C. Yan Cheng

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Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activity, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Daishu Han, Will M. Lee, and C. Yan Cheng

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Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Chris K.C. Wong, Will M. Lee, Daishu Han, and C. Yan Cheng

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Regulation of blood-testis barrier by actin binding proteins and protein kinases, Nan Li, Elizabeth I. Tang, and C. Yan Cheng

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Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice, Zhenghui Liu, Shutao Zhao, Qiaoyuan Chen, Keqin Yan, Peng Liu, Nan Li, C. Yan Cheng, Will M. Lee, and Daishu Han

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Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells, Xu Li, Cuixia Gao, Yupei Wu, C. Yan Cheng, Weiliang Xia, and Zhiping Zhang

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rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat Sertoli cells. An in vitro study, Ka-Wai Mok, Haiqi Chen, Will M. Lee, and C. Yan Cheng

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The mammalian blood–testis barrier: Its biology and regulation, Dolores D. Mruk and C. Yan Cheng

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The Warburg effect revisited—Lesson from the Sertoli cell, Pedro F. Oliveira, Ana D. Martins, Ana C. Moreira, C. Yan Cheng, and Marco G. Alves

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Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway, Yizhou Quan, Li Xia, Jiaxiang Shao, Shankai Yin, C. Yan Cheng, Weiliang Xia, and Wei-Qiang Gao

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Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes, Linlin Su, Yufei Zhang, C. Yan Cheng, Will M. Lee, Keping Ye, and Dahai Hu

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EB1 regulates tubulin and actin cytoskeletal networks at the Sertoli cell blood-testis barrier in male rats: An in vitro study, Elizabeth I. Tang, Ka-Wai Mok, Will M. Lee, and C. Yan Cheng

Submissions from 2014

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Biology of spermatogenesis—The challenges ahead, C. Yan Cheng

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Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium, C. Yan Cheng and Dolores D. Mruk

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Thyroid hormone function in the rat testis, Ying Gao, Will M. Lee, and C. Yan Cheng

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Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis, N. Ece Gungor-Ordueri, Ciler Celik-Ozenci, and C. Yan Cheng

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New insights into FAK function and regulation during spermatogenesis, N. Ece Gungor-Ordueri, Dolores D. Mruk, Hin Ting Wan, Elissa W.P. Wong, Ciler Celik-Ozenci, Pearl P.Y. Lie, and C. Yan Cheng

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Ezrin is an actin binding protein that regulates Sertoli cell and spermatid adhesion during spermatogenesis, N. Ece Gungor-Ordueri, Elizabeth I. Tang, Ciler Celik-Ozenci, and C. Yan Cheng

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Sertolin mediates blood-testis barrier restructuring, Michelle W.M. Li, C. Yan Cheng, and Dolores D. Mruk

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rpS6 regulates blood–testis barrier dynamics through Akt-mediated effects on MMP-9, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng

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Intercellular adhesion molecule 1: Recent findings and new concepts involved in mammalian spermatogenesis, Dolores D. Mruk, Xiang Xiao, Marta Lydka, Michelle W.M. Li, Barbara Bilinska, and C. Yan Cheng

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Actin binding proteins, spermatid transport and spermiation, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, Elizabeth I. Tang, Daishu Han, Will M. Lee, Elissa W.P. Wong, and C. Yan Cheng

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Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors, Michael Schumacher, Claudia Mattern, Abdel M. Ghoumari, J.P. Oudinet, Florencia Labombarda, Régine Sitruk-Ware, Alejandro De Nicola, and Rachida Guennoun

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Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr^407: An in vitro study, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis, H.T. Wan, Dolores D. Mruk, Elizabeth I. Tang, Xiang Xiao, Yan Ho Cheng, Elissa W.P. Wong, Chris K.C. Wong, and C. Yan Cheng

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Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis, Qing Wen, Qiao-Song Zheng, Xi-Xia Li, Zhao-Yuan Hu, Fei Gao, C. Yan Cheng, and Yi-Xun Liu

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N-WASP is required for structural integrity of the blood-testis barrier, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, R'ada Massarwa, Ka-Wai Mok, Nan Li, Chris K.C. Wong, Will M. Lee, Scott B. Snapper, Ben-Zion Shilo, Eyal D. Schejter, and C. Yan Cheng

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Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins, Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Will M. Lee, Constance M. John, Paul J. Turek, Bruno Silvestrini, and C. Yan Cheng

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Germ cell transport across the seminiferous epithelium during spermatogenesis, Xiang Xiao, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: An in vitro study, Xiang Xiao, Dolores D. Mruk, Elissa W.P. Wong, Will M. Lee, Daishu Han, Chris K.C. Wong, and C. Yan Cheng

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Cytokines, polarity proteins, and endosomal protein trafficking and signaling—The Sertoli cell blood–testis barrier system in vitro as a study model, Xiang Xiao, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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p204-initiated innate antiviral response in mouse Leydig cells, Weiwei Zhu, Peng Liu, Lili Yu, Qiaoyuan Chen, Zhenghui Liu, Keqin Yan, Will M. Lee, C. Yan Cheng, and Daishu Han

Submissions from 2013

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Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, and Dolores D. Mruk

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Spermatogenesis, Mammals, C. Yan Cheng and Dolores D. Mruk

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Why do we need male contraceptives?, C. Yan Cheng and Dolores D. Mruk

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The neural androgen receptor: A therapeutic target for myelin repair in chronic demyelination, Rashad Hussain, Abdel M. Ghoumari, Bartosz Bielecki, Jerome Steibel, Nelly Boehm, Philippe Liere, Wendy B. Macklin, Narender Kumar, Rene Habert, Sakina Mhaouty-Kodja, Francois Tronche, Régine Sitruk-Ware, Michael Schumacher, and M. Said Ghandour

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Signalling pathways regulating the blood–testis barrier, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk

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Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans, Kun Li, Ya Ni, Yi He, Wen-Ying Chen, Jian-Xin Lu, C. Yan Cheng, Renshan Ge, and Qi-Xian Shi

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Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis, Stephen Y.T. Li, Dolores D. Mruk, and C. Yan Cheng

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Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors, Axel Mann, Nikolas Friedrich, Anders Krarup, Jacqueline Weber, Emanuel Stiegeler, Birgit Dreier, Pavel Pugach, Melissa Robbiani, Tina Riedel, Kerstin Moehle, John A. Robinson, Peter Rusert, Andreas Pluckthun, and Alexandra Trkola

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Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the 'yin' and 'yang' effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, Ka-Wai Mok, Dolores D. Mruk, and C. Yan Cheng

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Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP), Xiao-jing Qian, Yan Ho Cheng, Pranitha Jenardhanan, Dolores D. Mruk, Premendu P. Mathur, Weiliang Xia, Bruno Silvestrini, and C. Yan Cheng

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Breast cancer resistance protein (Bcrp) and the testis—An unexpected turn of events, Xiao-jing Qian, Yan Ho Cheng, Dolores D. Mruk, and C. Yan Cheng

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Rai14 (Retinoic Acid Induced Protein 14) is involved in regulating F-Actin dynamics at the ectoplasmic specialization in the rat testis, Xiao-jing Qian, Dolores D. Mruk, and C. Yan Cheng

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Actin cross-linking protein palladin and spermatogenesis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng

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RAI14 (retinoic acid induced protein 14) is an F-actin regulator—Lesson from the testis, Xiao-jing Qian, Dolores D. Mruk, Yan Ho Cheng, and C. Yan Cheng

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Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, and C. Yan Cheng

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Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes, Xiao-jing Qian, Dolores D. Mruk, Elissa W.P. Wong, Pearl P.Y. Lie, and C. Yan Cheng

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Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone® gels, Mara Y. Roth, Niloufar Ilani, Christina Wang, Stephanie T. Page, William J. Bremner, Ronald S. Swerdloff, Clint Dart, Régine Sitruk-Ware, Narender Kumar, Diana Blithe, and John K. Amory

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Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation, Jiaxiang Shao, Tengyuan Liu, Qian Reuben Xie, Tingting Zhang, Hemei Yu, Boshi Wang, Weihai Ying, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia

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Germ cells contribute to the function of the Sertoli cell barrier: An in vitro study, Linlin Su, Ilona A. Kopera-Sobota, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk

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Regulation of actin dynamics and protein trafficking during spermatogenesis—Insights into a complex process, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng

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MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis, Elizabeth I. Tang and Dolores D. Mruk

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p-FAK-Tyr^397 regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization, Hin Ting Wan, Dolores D. Mruk, Stephen Y.T. Li, Ka-Wai Mok, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Targeting testis-specific proteins to inhibit spermatogenesis: Lesson from endocrine disrupting chemicals, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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The apical ES–BTB–BM functional axis is an emerging target for toxicant-induced infertility, Hin Ting Wan, Dolores D. Mruk, Chris K.C. Wong, and C. Yan Cheng

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NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics, Elissa W.P. Wong and C. Yan Cheng

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Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex, Elissa W.P. Wong, Will M. Lee, and C. Yan Cheng

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Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat, Xiang Xiao, C. Yan Cheng, and Dolores D. Mruk

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c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood–testis barrier axis via its effects on protein recruitment and distribution, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng

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Intercellular adhesion molecules (ICAMs) and spermatogenesis, Xiang Xiao, Dolores D. Mruk, and C. Yan Cheng

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Male contraceptive Adjudin is a potential anti-cancer drug, Qian Reuben Xie, Yewei Liu, Jiaxiang Shao, Jian Yang, Tengyuan Liu, Tingting Zhang, Boshi Wang, Dolores D. Mruk, Bruno Silvestrini, C. Yan Cheng, and Weiliang Xia

Submissions from 2012

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The blood–testis barrier and its implications for male contraception, C. Yan Cheng and Dolores D. Mruk

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The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics, Pearl P.Y. Lie, C. Yan Cheng, and Dolores D. Mruk

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Focal adhesion kinase-Tyr^407 and -Tyr^397 exhibit antagonistic effects on blood–testis barrier dynamics in the rat, Pearl P.Y. Lie, Dolores D. Mruk, Ka-Wai Mok, Linlin Su, Will M. Lee, and C. Yan Cheng

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Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton, Marta Lydka, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk

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Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility, Ka-Wai Mok, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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rpS6 regulates blood–testis barrier dynamics by affecting F-actin organization and protein recruitment, Ka-Wai Mok, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

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Drug transporters in spermatogenesis: A re-evaluation of recent data on P-glycoprotein, Dolores D. Mruk and C. Yan Cheng

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In search of suitable in vitro models to study germ cell movement across the blood-testis barrier, Dolores D. Mruk and C. Yan Cheng

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Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines, Linlin Su, Dolores D. Mruk, and C. Yan Cheng

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Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor, Linlin Su, Dolores D. Mruk, and C. Yan Cheng

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A peptide derived from laminin-γ3 reversibly impairs spermatogenesis in rats, Linlin Su, Dolores D. Mruk, Pearl P.Y. Lie, Bruno Silvestrini, and C. Yan Cheng

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Filamin A: A regulator of blood-testis barrier assembly during post-natal development, Wenhui Su, Dolores D. Mruk, and C. Yan Cheng

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Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis, Wenhui Su, Dolores D. Mruk, Pearl P.Y. Lie, Wing-Yee Lui, and C. Yan Cheng

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The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood–testis barrier dynamics and spermatid polarity during spermatogenesis, Wenhui Su, Elissa W.P. Wong, Dolores D. Mruk, and C. Yan Cheng

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Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis, Elizabeth I. Tang, Xiang Xiao, Dolores D. Mruk, Xiao-jing Qian, Ka-Wai Mok, Pranitha Jenardhanan, Will M. Lee, Premendu P. Mathur, and C. Yan Cheng

Submissions from 2011

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Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro, Othell Begay, Ninochka Jean-Pierre, Ciby J. Abraham, Anne Chudolij, Samantha Seidor, Aixa Rodriguez, Brian E. Ford, Marcus Henderson, David Katz, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero

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Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood–testis-barrier-hemidesmosome functional axis in the testis, C. Yan Cheng, Pearl P.Y. Lie, Ka-Wai Mok, Yan Ho Cheng, Elissa W.P. Wong, Jayakanthan Mannu, Premendu P. Mathur, Helen H.N. Yan, and Dolores D. Mruk

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Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3, C. Yan Cheng, Pearl P.Y. Lie, Elissa W.P. Wong, Dolores D. Mruk, and Bruno Silvestrini

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Actin binding proteins and spermiogenesis: Some unexpected findings, C. Yan Cheng and Dolores D. Mruk

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Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3, C. Yan Cheng and Dolores D. Mruk

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Regulation of blood–testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Dolores D. Mruk, Helen H.N. Yan, Ka-Wai Mok, Jayakanthan Mannu, Premendu P. Mathur, Wing-Yee Lui, Will M. Lee, Michele Bonanomi, and Bruno Silvestrini

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Environmental toxicants and male reproductive function, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Michelle W.M. Li, Linlin Su, Erica R. Siu, Helen H.N. Yan, J. Mannu, Premendu P. Mathur, Michele Bonanomi, Bruno Silvestrini, and Dolores D. Mruk

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Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis, C. Yan Cheng, Elissa W.P. Wong, Pearl P.Y. Lie, Dolores D. Mruk, Xiang Xiao, Michelle W.M. Li, Wing Yee Lui, and Will M. Lee

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Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis, Yan Ho Cheng, Elissa W.P. Wong, and C. Yan Cheng