As we add more content to Knowledge Commons, some collections will initially have a limited number of resources. Please check back regularly to find content.
Submissions from 2024
Ex vivo colonic tissue susceptibility to HIV-1 in cisgender men and women, Patrick Barnable, Sampurna Mukhopadhyay, Larisa Kizima, Narender Kumar, Marlena Gehret Plagianos, Saurabh Mehandru, and Natalia Teleshova
Submissions from 2023
Herpes simplex virus type 2 prevalence and association with inflammatory cytokines among sexual and gender minorities living with and without HIV-1 from Lagos, Nigeria, Meropi Aravantinou, Marlena Gehret Plagianos, Afoke Kokogho, Sylvia Adebajo, Rebecca G. Nowak, Elizabeth Shoyemi, Charles Ekeh, Kara Lombardi, Sheila Peel, Stefan Baral, Trevor A. Crowell, Nina Derby, Natalia Teleshova, and Elena Martinelli
Influence of hormonal contraceptive use and HIV on cervicovaginal cytokines and microbiota in Malawi, Lisa Haddad, Jennifer H. Tang, Nicole L. Davis, Athena P. Kourtis, Lameck Chinula, Albans Msika, Gerald Tegha, Mina C. Hosseinipour, Julie A.E. Nelson, Marcia M. Hobbs, Pawel Gajer, Jacques Ravel, and Kristina De Paris
Vaginal microbiome, antiretroviral concentrations, and HIV genital shedding in the setting of hormonal contraception initiation in Malawi, Alyssa M. Lantz, Mackenzie L. Cottrell, Amanda H. Corbett, Lameck Chinula, Athena P. Kourtis, Julie A.E. Nelson, Gerald Tegha, Stacey Hurst, Pawel Gajer, Jacques Ravel, Lisa Haddad, Jennifer H. Tang, and Melanie R. Nicol
Drug reprofiling to identify potential HIV-1 protease inhibitors, Sunday Okafor, Abigail Meyer, Jay Gadsden, Fadi Ahmed, Lilian Guzmán, Hashim Ahmed, José Fernández-Romero, and Pavimol Angsantikul
Characterization of viruses in Phase 3 and Phase 3b trials (the Ring Study and the Dapivirine Ring Extended Access and Monitoring Trial) of the Dapivirine vaginal ring for human immunodeficiency virus type 1 infection risk reduction, John Steytler, Charles Craig, Elna van der Ryst, Ben Van Baelen, Jeremy Nuttall, Neliette van Niekerk, John Mellors, Urvi Parikh, and Carole Wallis
Clinical presentation, treatment response, and virology outcomes of women who seroconverted in the Dapivirine Vaginal Ring Trials—The Ring Study and DREAM, John Steytler, Elna van der Ryst, Charles Craig, Ben Van Baelen, Jeremy Nuttall, Neliette van Niekerk, John Mellors, Urvi Parikh, and Carole Wallis
Submissions from 2022
Discovery of novel HIV protease inhibitors using modern computational techniques, Sunday Okafor and Pavimol Angsantikul
Discovery of novel HIV protease inhibitors using modern computational techniques, Sunday Okafor, Pavimol Angsantikul, and Hashim Ahmed
Drug repurposing for HIV-1 protease inhibitors: High throughput virtual screening, rigid molecular docking and molecular dynamics studies, Sunday Okafor, Pavimol Angsantikul, and Hashim Ahmed
Results of a phase 1, randomized, placebo controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel, Natalia Teleshova, Marla J. Keller, José Fernández-Romero, Barbara Friedland, George W. Creasy, Marlena Gehret Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U. Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R. O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N. Fichorova, Tamara Kalir, and Thomas Zydowsky
Estradiol inhibits HIV-1BaL infection and induces CFL1 expression in peripheral blood mononuclear cells and endocervical mucosa, Neeharika Verma, Sampurna Mukhopadhyay, Patrick Barnable, Marlena Gehret Plagianos, and Natalia Teleshova
Submissions from 2021
Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies, Ines Frank, Maria Sole Cigoli, Muhammad Shafique Arif, Marissa D. Fahlberg, Stephanie Maldonado, Giulia Calenda, Amarendra Pegu, Eun Sung Yang, Reda Rawi, Gwo-Yu Chuang, Hui Geng, Cuiping Liu, Tongqing Zhou, Peter D. Kwong, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Christine M. Fennessey, Brandon F. Keele, Monica Vaccari, Thomas J. Hope, Anthony S. Fauci, John R. Mascola, and Elena Martinelli
HIV-1 establishes a sanctuary site in the testis by permeating the BTB through changes in cytoskeletal organization, Siwen Wu, Ines Frank, Nina Derby, Elena Martinelli, and C. Yan Cheng
Submissions from 2020
No-flip ShangRing circumcision in 10-12 year old boys: Results from randomized clinical trials in Kenya, Omar Al Hussein Alawamlh, Quentin Awori, Mark Barone, Soo-Jeong Kim, Marc Goldstein, Philip S. Li, and Richard K. Lee
Anti-α4β7 monoclonal antibody–conjugated nanoparticles block integrin α4β7 on intravaginal T cells in rhesus macaques, Sidi Yang, Geraldine Arrode-Bruses, Ines Frank, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, and Emmanuel A. Ho
Submissions from 2019
Use of topical versus injectable anaesthesia for ShangRing circumcisions in men and boys in Kenya: Results from a randomized controlled trial, Quentin Awori, Philip S. Li, Richard K. Lee, Daniel Ouma, Millicent Oundo, Mukhaye Barasa, Nereah Obura, David Mwamkita, Raymond Otieno Simba, Jairus Oketch, Nixon Nyangweso, Mary N. Maina, Nicholas Kiswi, Michael Kirui, Betty Chirchir, Marc Goldstein, and Mark Barone
New subtype B containing HIV-1 circulating recombinant of sub-Saharan Africa origin in Nigerian men who have sex with men, Erik Billings, Gustavo H. Kijak, Eric Sanders-Buell, Nicaise Ndembi, Anne Marie O'Sullivan, Sylvia Adebajo, Afoke Kokogho, Mark Milazzo, Kara Lombardi, Stefan Baral, Rebecca G. Nowak, Habib O. Ramadhani, Robert Gramzinski, Merlin L. Robb, Nelson L. Michael, Manhattan E. Charurat, Julie Ake, Trevor A. Crowell, Sodsai Tovanabutra, MHRP Viral Sequencing Core, and TRUST/RV368 Study Group
Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques, Giulia Calenda, Ines Frank, Geraldine Arrode-Bruses, Amarendra Pegu, Keyun Wang, James Arthos, Claudia Cicala, Kenneth A. Rogers, Lisa Shirreff, Brooke Grasperge, James L. Blanchard, Stephanie Maldonado, Kevin Roberts, Agegnehu Gettie, Francois Villinger, Anthony S. Fauci, John R. Mascola, and Elena Martinelli
Mucosal susceptibility to human immunodeficiency virus infection in the proliferative and secretory phases of the menstrual cycle, Giulia Calenda, Guillermo Villegas, Alexandra Reis, Lily Millen, Patrick Barnable, Lisa Mamkina, Narender Kumar, Kevin Roberts, Tamara Kalir, Elena Martinelli, Rhoda Sperling, and Natalia Teleshova
Topical formulations to prevent sexually transmitted infections: Are we on track?, José Fernández-Romero, Maria Gabriela Paglini, and Thomas Zydowsky
A tat/rev induced limiting dilution assay to measure viral reservoirs in non-human primate models of HIV infection, Ines Frank, Arpan Acharya, Nanda K. Routhu, Meropi Aravantinou, Justin L. Harper, Stephanie Maldonado, Maria Sole Cigoli, Stanka Semova, Svetlana Mazel, Mirko Paiardini, Nina Derby, Siddappa Byrareddy, and Elena Martinelli
Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya, Elijah Odoyo-June, Nandi Owuor, Saida Kassim, Stephanie Davis, Kawango Agot, Kennedy Serrem, George Otieno, Quentin Awori, Jonas Hines, Carlos Toledo, Catey Laube, Christine Kisia, Appolonia Aoko, Vincent Ojiambo, Zebedee Mwandi, Ambrose Juma, and Bartilol Kigen
Submissions from 2018
Integrin α_4β_7 blockade preferentially impacts CCR6^+ lymphocyte subsets in blood and mucosal tissues of naive rhesus macaques, Giulia Calenda, Rassamon Keawvichit, Geraldine Arrode-Bruses, Kovit Pattanapanyasat, Ines Frank, Siddappa Byrareddy, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Keith A. Reimann, Aftab A. Ansari, and Elena Martinelli
Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo, Nina Derby, Manjari Lal, Meropi Aravantinou, Larisa Kizima, Patrick Barnable, Aixa Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R. O'Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José Fernández-Romero, and Thomas Zydowsky
Development of a vaginal fast-dissolving insert combining griffithsin and carrageenan for potential use against sexually transmitted infections, Manjari Lal, Manshun Lai, Shweta Ugaonkar, Asa Wesenberg, Larisa Kizima, Aixa Rodriguez, Keith Levendosky, Olga Mizenina, José Fernández-Romero, and Thomas Zydowsky
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7, Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa Byrareddy, Philip J. Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D. Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A. Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S. Fauci, and James Arthos
MAdCAM costimulation through Integrin-α_4β_7 promotes HIV replication, Fatima Nawaz, Livia R. Goes, Jocelyn C. Ray, Ronke Olowojesiku, Alia Sajani, Aftab A. Ansari, Ian Perrone, Joseph Hiatt, Donald Van Ryk, Danlan Wei, Mia Waliszewski, Marcelo A. Soares, Katija Jelicic, Mark Connors, Stephen A. Migueles, Elena Martinelli, Francois Villinger, Claudia Cicala, Anthony S. Fauci, and James Arthos
Study to evaluate the safety of griffithsin in a carrageenan gel in healthy women, Population Council
A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective, Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng
Submissions from 2017
Experimental oral herpes simplex virus-1 (HSV-1) co-infection in simian immunodeficiency virus (SIV)-infected rhesus macaques, Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, and Nina Derby
MZC gel inhibits SHIV-RT and HSV-2 in macaque vaginal mucosa and SHIV-RT in rectal mucosa, Giulia Calenda, Guillermo Villegas, Patrick Barnable, Claudia Litterst, Keith Levendosky, Agegnehu Gettie, Michael Cooney, James Blanchard, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques, Nina Derby, Meropi Aravantinou, Jessica Kenney, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Olga Mizenina, Keith Levendosky, Michael Cooney, Samantha Seidor, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Achieving the optimal vaginal state: Using vaginal products and study gels in Uganda, Zimbabwe, and South Africa, Zoe Duby, Barbara Mensch, Miriam Hartmann, Elizabeth T. Montgomery, Imelda Mahaka, Linda-Gail Bekker, and Ariane van der Straten
Pixuna virus modifies host cell cytoskeleton to secure infection, Pedro Ignacio Gil, Guillermo Albrieu-Llinás, Estela Cecilia Mlewski, Marina Monetti, Laura Fozzatti, Cecilia Cuffini, José Fernández-Romero, Patricia Kunda, and Maria Gabriela Paglini
MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1, Olga Mizenina, Mayla Hsu, Ninochka Jean-Pierre, Meropi Aravantinou, Keith Levendosky, Maria Gabriela Paglini, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
A fresh look at an old problem, Thomas Zydowsky
Submissions from 2016
PolyICLC exerts pro- and anti-HIV effects on the DC-T cell milieu in vitro and in vivo, Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres M. Salazar, Michael Piatak Jr., Jeffrey D. Lifson, Melissa Robbiani, and Nina Derby
A small molecule, which competes with MAdCAM-1, activates integrin α4β7 and fails to prevent mucosal transmission of SHIV-SF162P3, Geraldine Arrode-Bruses, Diana J. Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, and Elena Martinelli
Surgical outcomes of newly trained ShangRing circumcision providers, Quentin Awori, Richard K. Lee, Philip S. Li, Robert Zulu, Kawango Agot, Stephanie Combes, Raymond Otieno Simba, Catherine Hart, Jaim Jou Lai, Zude Zyambo, Marc Goldstein, Paul Feldblum, and Mark Barone
A first-in-human trial of MIV-150 and zinc acetate co-formulated in a carrageenan gel: Safety, pharmacokinetics, acceptability, adherence and pharmacodynamics, Barbara Friedland, Craig Hoesley, Marlena Gehret Plagianos, Elena Hoskin, Shimin Zhang, Natalia Teleshova, Mohcine Alami, Lea Novak, Kyle Kleinbeck, Lauren L. Katzen, Thomas Zydowsky, José Fernández-Romero, and George W. Creasy
Baseline predictors of high adherence to a coitally dependent microbicide gel based on an objective marker of use: Findings from the Carraguard Phase 3 Trial, Barbara Friedland, Marie Stoner, Michelle Chau, Marlena Gehret Plagianos, Sumentheran N. Govender, Neetha S. Morar, Lydia Altini, Stephanie Skoler-Karpoff, Khatija Ahmed, Gita Ramjee, Constance Monedi, Robin A. Maguire, and Pekka Lahteenmaki
Rectal HSV-2 infection may increase rectal SIV acquisition even in the context of SIVΔnef vaccination, Natalia Guerra-Perez, Meropi Aravantinou, Filippo Veglia, Diana J. Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli
Multipurpose prevention approaches with antiretroviral-based formulations, Ninochka Jean-Pierre, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Samantha Seidor, Michael Cooney, Meredith R. Clark, Gustavo F. Doncel, Melissa Robbiani, Thomas Zydowsky, Natalia Teleshova, and José Fernández-Romero
In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel, Akiva P. Novetsky, Marla J. Keller, Ana Gradissimo, Zigui Chen, Stephanie L. Morgan, Xiaonan Xue, Howard D. Strickler, José Fernández-Romero, Robert Burk, and Mark H. Einstein
A novel microbicide/contraceptive intravaginal ring protects macaque genital mucosa against SHIV-RT infection ex vivo, Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael Cooney, Melissa Robbiani, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
In vitro exposure to PC-1005 and cervicovaginal lavage fluid from women vaginally administered PC-1005 inhibits HIV-1 and HSV-2 infection in human cervical mucosa, Guillermo Villegas, Giulia Calenda, Shimin Zhang, Olga Mizenina, Kyle Kleinbeck, Michael Cooney, Craig Hoesley, George W. Creasy, Barbara Friedland, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
Submissions from 2015
MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model, Patrick Barnable, Giulia Calenda, Thierry Bonnaire, Radhika Menon, Keith Levendosky, Agegnehu Gettie, James F. Blanchard, Michael Cooney, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova
Not just HIV: Preventing other viral sexually transmitted infections, José Fernández-Romero
Multipurpose prevention technologies: The future of HIV and STI protection, José Fernández-Romero, Carolyn Deal, Betsy C. Herold, John Schiller, Dorothy Patton, Thomas Zydowsky, Joseph W. Romano, Christopher D. Petro, and Manjulaa Narasimhan
Preclinical assessments of vaginal microbicide candidate safety and efficacy, José Fernández-Romero, Natalia Teleshova, Thomas Zydowsky, and Melissa Robbiani
Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection, Natalia Guerra-Perez, Ines Frank, Filippo Veglia, Meropi Aravantinou, Diana J. Goode, James L. Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli
Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus, Keith Levendosky, Olga Mizenina, Elena Martinelli, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Kyle Kleinbeck, Thierry Bonnaire, Melissa Robbiani, Thomas Zydowsky, Barry R. O'Keefe, and José Fernández-Romero
Hormonal contraception and the risk of HIV acquisition: An individual participant data meta-analysis, Charles S. Morrison, Pai-lien Chen, Cynthia Kwok, Jared M. Baeten, Joelle Brown, Angela M. Cook, Lut Van Damme, Sinead Delany-Moretlwe, Suzanna C. Francis, Barbara Friedland, Richard J. Hayes, Renee Heffron, Saidi H. Kapiga, Quarraisha Abdool Karim, Stephanie Skoler-Karpoff, Rupert Kaul, R. Scott McClelland, Sheena McCormack, Nuala McGrath, Landon Myer, Helen Rees, Ariane van der Straten, Deborah Watson-Jones, Janneke van de Wijgert, Randy Stalter, and Nicola Low
Biomedical research at the Population Council, Population Council
Safety, pharmacokinetics and acceptability of PC-1005 for vaginal use, Population Council
An intravaginal ring for the simultaneous delivery of an HIV-1 maturation inhibitor and reverse-transcriptase inhibitor for prophylaxis of HIV transmission, Shweta Ugaonkar, Justin T. Clark, Lexie B. English, Todd J. Johnson, Karen W. Buckheit, Robert J. Bahde, Daniel H. Appella, Robert W. Buckheit Jr., and Patrick F. Kiser
A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Samantha Seidor, Olga Mizenina, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Keith Levendosky, Jessica Kenney, Meropi Aravantinou, Nina Derby, Brooke Grasperge, Agegnehu Gettie, James F. Blanchard, Narender Kumar, Kevin Roberts, Melissa Robbiani, José Fernández-Romero, and Thomas Zydowsky
Submissions from 2014
A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants, Patrick Barnable, Giulia Calenda, Louise Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Michael Cooney, Kevin Roberts, Rhoda Sperling, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, Melissa Robbiani, and Natalia Teleshova
First-in-human safety and pharmacokinetics (PK) of a MIV-150/zinc acetate/carrageenan gel (PC-1005), George W. Creasy, Craig Hoesley, Barbara Friedland, Shimin Zhang, Marlena Gehret Plagianos, Kyle Kleinbeck, Keith Levendosky, José Fernández-Romero, and Thomas Zydowsky
Microbicidas para la prevención de infecciones de transmisión sexual: estado actual y estrategias para la evaluación preclínica de nuevos candidatos, José Fernández-Romero, Pedro I. Gil, Viviana Re, Melissa Robbiani, and Gabriela Paglini
Sex hormones selectively impact the endocervical mucosal microenvironment: Implications for HIV transmission, Diana J. Goode, Meropi Aravantinou, Sebastian Jarl, Rosaline Truong, Nina Derby, Natalia Guerra-Perez, Jessica Kenney, James Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli
HSV-2-driven increase in the expression of α_4β_7 correlates with increased susceptibility to vaginal SHIV_SF162P3 infection, Diana J. Goode, Rosaline Truong, Guillermo Villegas, Giulia Calenda, Natalia Guerra-Perez, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli
Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits, Carolien Grammen, Myriam Baes, Steven Haenen, Jasper Verguts, Koen Augustyns, Thomas Zydowsky, Paolo La Colla, Patrick Augustijns, and Joachim Brouwers
A combination microbicide gel protects macaques against vaginal SHIV-RT infection, but only partially reduces HSV-2 infection after a single high-dose co-challenge, Mayla Hsu, Meropi Aravantinou, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Nina Derby, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques, Mayla Hsu, Brandon F. Keele, Meropi Aravantinou, Noa Krawczyk, Samantha Seidor, Ciby J. Abraham, Shimin Zhang, Aixa Rodriguez, Larisa Kizima, Nina Derby, Ninochka Jean-Pierre, Olga Mizenina, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
MZC and 1% TFV gel: Multipurpose prevention approaches, Ninochka Jean-Pierre, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Samantha Seidor, Meredith R. Clark, Gustavo F. Doncel, Melissa Robbiani, Thomas Zydowsky, Natalia Teleshova, and José Fernández-Romero
Short communication: A repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides, Jessica Kenney, Nina Derby, Meropi Aravantinou, Kyle Kleinbeck, Ines Frank, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Thomas Zydowsky, and Melissa Robbiani
A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV, Larisa Kizima, Aixa Rodriguez, Jessica Kenney, Nina Derby, Olga Mizenina, Radhika Menon, Samantha Seidor, Shimin Zhang, Keith Levendosky, Ninochka Jean-Pierre, Pavel Pugach, Guillermo Villegas, Brian E. Ford, Agegnehu Gettie, James F. Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Maria Gabriela Paglini, Natalia Teleshova, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
Antiviral activity and mode of action of Griffithsin against HSV-2 and HPV: Preliminary studies of a potential non-ARV combination microbicide, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Larisa Kizima, Aixa Rodriguez, Ninochka Jean-Pierre, Melissa Robbiani, Barry R. O'Keefe, Thomas Zydowsky, and José Fernández-Romero
MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection, Louise Ouattara, Patrick Barnable, Paul Mawson, Samantha Seidor, Thomas Zydowsky, Larisa Kizima, Aixa Rodriguez, José Fernández-Romero, Michael Cooney, Kevin Roberts, Agegnehu Gettie, James Blanchard, Melissa Robbiani, and Natalia Teleshova
In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition, Aixa Rodriguez, Kyle Kleinbeck, Olga Mizenina, Larisa Kizima, Keith Levendosky, Ninochka Jean-Pierre, Guillermo Villegas, Brian E. Ford, Michael Cooney, Natalia Teleshova, Melissa Robbiani, Betsy C. Herold, Thomas Zydowsky, and José Fernández-Romero
A novel intravaginal ring (IVR) protects macaques against SHIV-RT infection and reduces HSV-2 shedding after repeated SHIV-RT/HSV-2 co-challenge, Thomas Zydowsky, Jessica Kenney, Meropi Aravantinou, Shweta Ugaonkar, Nina Derby, Larisa Kizima, Shimin Zhang, Olga Mizenina, José Fernández-Romero, and Melissa Robbiani
Submissions from 2013
In search of the optimal delivery method for anti-HIV microbicides: Are intravaginal rings the way forward?, Nina Derby, Thomas Zydowsky, and Melissa Robbiani
A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo, Jessica Kenney; Aixa Rodriguez; Larisa Kizima; Samantha Seidor; Radhika Menon; Ninochka Jean-Pierre; Pavel Pugach; Keith Levendosky; Nina Derby; Agegnehu Gettie; James Blanchard; Michael Piatak, Jr.; Jeffrey D. Lifson; Gabriela Paglini; Thomas Zydowsky; Melissa Robbiani; and José Fernández-Romero
Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors, Axel Mann, Nikolas Friedrich, Anders Krarup, Jacqueline Weber, Emanuel Stiegeler, Birgit Dreier, Pavel Pugach, Melissa Robbiani, Tina Riedel, Kerstin Moehle, John A. Robinson, Peter Rusert, Andreas Pluckthun, and Alexandra Trkola
The frequency of α4β7high memory CD4+ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection, Elena Martinelli; Filippo Veglia; Diana J. Goode; Natalia Guerra-Perez; Meropi Aravantinou; James Arthos; Michael Piatak, Jr.; Jeffrey D. Lifson; James Blanchard; Agegnehu Gettie; and Melissa Robbiani
Simian immunodeficiency virus interactions with macaque dendritic cells, Natalia Teleshova, Nina Derby, Elena Martinelli, Pavel Pugach, Giulia Calenda, and Melissa Robbiani
Submissions from 2012
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection, Meropi Aravantinou, Rachel Singer, Nina Derby, Giulia Calenda, Paul Mawson, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Guillermo Villegas, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, Natalia Teleshova, and Melissa Robbiani
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high dose HSV-2 vaginal and rectal challenge, José Fernández-Romero, Ciby J. Abraham, Aixa Rodriguez, Larisa Kizima, Ninochka Jean-Pierre, Radhika Menon, Othell Begay, Samantha Seidor, Brian E. Ford, Pedro I. Gil, Jennifer Peters, David Katz, Melissa Robbiani, and Thomas Zydowsky
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy, Edith Jasny, Suzanne Geer, Ines Frank, Panagiotis Vagenas, Meropi Aravantinou, Andres M. Salazar, Jeffrey D. Lifson, Michael Piatak Jr., Agegnehu Gettie, James L. Blanchard, and Melissa Robbiani
A single dose of a MIV-150/zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use, Jessica Kenney, Rachel Singer, Nina Derby, Meropi Aravantinou, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Shimin Zhang, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Acceptability in microbicide and PrEP trials: Current status and a reconceptualization, Barbara Mensch, Ariane van der Straten, and Lauren L. Katzen
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques, Rachel Singer, Paul Mawson, Nina Derby, Aixa Rodriguez, Larisa Kizima, Radhika Menon, Daniel Goldman, Jessica Kenney, Meropi Aravantinou, Samantha Seidor, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Melissa Robbiani, and Thomas Zydowsky
Submissions from 2011
Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro, Othell Begay, Ninochka Jean-Pierre, Ciby J. Abraham, Anne Chudolij, Samantha Seidor, Aixa Rodriguez, Brian E. Ford, Marcus Henderson, David Katz, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero
Myeloid dendritic cells in HIV-1 infection, Nina Derby, Elena Martinelli, and Melissa Robbiani
Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection, Ines Frank and Melissa Robbiani
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target, Elena Martinelli, Hugo Tharinger, Ines Frank, James Arthos, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques, Rachel Singer, Nina Derby, Aixa Rodriguez, Larisa Kizima, Jessica Kenney, Meropi Aravantinou, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids, Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, and Peter D. Sun
Submissions from 2010
Expanded safety and acceptability of the candidate vaginal microbicide Carraguard® in South Africa, Lydia Altini, Kelly Blanchard, Nicol Coetzee, Alana de Kock, Christopher J. Elias, Charlotte Ellertson, Barbara Friedland, Anwar Hoosen, Heidi E. Jones, Peter H. Kilmarx, Mabitso Marumo, C. Elizabeth McGrory, Constance Monedi, Gugulethu Ndlovu, Bels Nkompala, Annalie Pistorius, Gita Ramjee, Mohlatlego Sebola, Annik Sorhaindo, Abigail Norris Turner, Kathryn Tweedy, Janneke van de Wijgert, Manuela M. Williams, and Beverly Winikoff
In vivo binding and retention of CD4-Specific DARPin 57.2 in macaques, Pavel Pugach, Anders Krarup, Agegnehu Gettie, Marcelo Kuroda, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Alexandra Trkola, and Melissa Robbiani
Horizons: Looking back, moving forward, Naomi Rutenberg and Deborah Weiss
A tonsillar polyICLC/At-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation, Panagiotis Vagenas, Meropi Aravantinou, Vennansha G. Williams, Edith Jasny, Michael Piatak Jr., Jeffrey D. Lifson, Andres M. Salazar, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Submissions from 2009
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy, Federica Crostarosa, Meropi Aravantinou, Onome J. Akpogheneta, Edith Jasny, Andrew Shaw, Jessica Kenney, Michael Piatak Jr., Jeffrey D. Lifson, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Thomas M. Zydowsky, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G, Susanna Trapp, Nina Derby, Rachel Singer, Andrew Shaw, Vennansha G. Williams, Stuart G. Turville, Julian W. Bess Jr., Jeffrey D. Lifson, and Melissa Robbiani
Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239, Panagiotis Vagenas; Vennansha G. Williams; Michael Piatak, Jr.; Julian W. Bess; Jeffrey D. Lifson; James Blanchard; Agegnehu Gettie; and Melissa Robbiani
Submissions from 2008
A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells, Ines Frank, Hella Stössel, Agegnehu Gettie, Stuart G. Turville, Julian W. Bess, Jeffrey D. Lifson, Irving Sivin, Nikolaus Romani, and Melissa Robbiani
CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics, Andreas Schweizer, Peter Rusert, Livia Berlinger, Claudia R. Ruprecht, Axel Mann, Stéphanie Corthesy, Stuart G. Turville, Meropi Aravantinou, Marek Fischer, Melissa Robbiani, Patrick Amstutz, and Alexandra Trkola