Submissions from 2013
Use of the dye stain assay and ultraviolet light test for assessing vaginal insertion of placebo-filled applicators before and after sex, Marla J. Keller, Niall Buckley, Lauren L. Katzen, Jennifer Walsh, Barbara Friedland, Sarah A. Littlefield, Juan Lin, Xiaonan Xue, Terri Cornelison, Betsy C. Herold, and Mark H. Einstein
A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo, Jessica Kenney; Aixa Rodriguez; Larisa Kizima; Samantha Seidor; Radhika Menon; Ninochka Jean-Pierre; Pavel Pugach; Keith Levendosky; Nina Derby; Agegnehu Gettie; James Blanchard; Michael Piatak, Jr.; Jeffrey D. Lifson; Gabriela Paglini; Thomas Zydowsky; Melissa Robbiani; and José Fernández-Romero
Lost in translation: Assessing effectiveness of focus group questioning techniques to develop improved translation of terminology used in HIV prevention clinical trials, Natasha Mack, Catalina B. Ramirez, Barbara Friedland, and Soori Nnko
Characteristics of female sex workers in southern India willing and unwilling to participate in a placebo gel trial, Barbara Mensch, Barbara Friedland, Sharon Abbott, Lauren L. Katzen, Waimar Tun, Christine A. Kelly, Avina Sarna, Aylur K. Srikrishnan, and Suniti Solomon
Prevalence of HIV-1 drug resistance among women screening for HIV prevention trials in KwaZulu-Natal, South Africa (MTN-009), Urvi M. Parikh, Photini Kiepiela, Shayhana Ganesh, Kailazarid Gomez, Stephanie Horn, Krista Eskay, Cliff Kelly, Barbara Mensch, Pamina M. Gorbach, Lydia Soto-Torres, Gita Ramjee, John W. Mellors, and IPTc Taskforce
A toolkit for developing bilingual lexicons for international HIV prevention clinical trials, Catalina B. Ramirez, Natasha Mack, and Barbara Friedland
Sexually transmitted infections and reproductive health morbidity in a cohort of female sex workers screened for a microbicide feasibility study in Nellore, India, Avina Sarna, Barbara Friedland, Aylur K. Srikrishnan, Lauren L. Katzen, Waimar Tun, Sharon Abbott, Ulrike Rawiel, Christine A. Kelly, C.S. Shalini, Suniti Solomon, and Barbara Mensch
Evaluation of 3 approaches for assessing adherence to vaginal gel application in clinical trials, Ariane van der Straten, Helen Cheng, Barbara Mensch, Barbara Friedland, Lauren L. Katzen, Sarah A. Littlefield, Niall Buckley, Lilia Espinoza, Marla J. Keller, Betsy C. Herold, and Mark H. Einstein
Microbicide clinical trial adherence: Insights for introduction, Cynthia Woodsong, Kathleen M. MacQueen, K. Rivet Amico, Barbara Friedland, Mitzy Gafos, Leila Mansoor, Elizabeth E. Tolley, and Sheena McCormack
Submissions from 2012
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection, Meropi Aravantinou, Rachel Singer, Nina Derby, Giulia Calenda, Paul Mawson, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Guillermo Villegas, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, Natalia Teleshova, and Melissa Robbiani
Shaping the operations research agenda for antiretroviral-based prevention products for women: Gels and rings, Martha Brady and C. Elizabeth McGrory
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high dose HSV-2 vaginal and rectal challenge, José Fernández-Romero, Ciby J. Abraham, Aixa Rodriguez, Larisa Kizima, Ninochka Jean-Pierre, Radhika Menon, Othell Begay, Samantha Seidor, Brian E. Ford, Pedro I. Gil, Jennifer Peters, David Katz, Melissa Robbiani, and Thomas Zydowsky
2012 IPM Annual Report—From Science to Solutions: Developing New Health Technologies for Women, International Partnership for Microbicides
Maternal health and HIV/AIDS, International Partnership for Microbicides
A single dose of a MIV-150/zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use, Jessica Kenney, Rachel Singer, Nina Derby, Meropi Aravantinou, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Shimin Zhang, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Acceptability in microbicide and PrEP trials: Current status and a reconceptualization, Barbara Mensch, Ariane van der Straten, and Lauren L. Katzen
Nonclinical development needs and regulatory requirements for multipurpose prevention technologies: A primer, Joseph W. Romano, Martha Brady, and Judy Manning
Non-specific microbicide development: Then and now, Joseph W. Romano, Melissa Robbiani, Gustavo F. Doncel, and Thomas Moench
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques, Rachel Singer, Paul Mawson, Nina Derby, Aixa Rodriguez, Larisa Kizima, Radhika Menon, Daniel Goldman, Jessica Kenney, Meropi Aravantinou, Samantha Seidor, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Melissa Robbiani, and Thomas Zydowsky
Submissions from 2011
Constructing a critical path for product development, commercialization, and access, Martha Brady
Facilitating regulatory approval of multipurpose prevention technologies for sexual and reproductive health, Martha Brady
Day of dialogue on multipurpose prevention technologies: Toward clarity in nomenclature, Martha Brady and C. Elizabeth McGrory
What regulatory guidance exists for multipurpose prevention technologies (MPTs)? A review of key guidance documents and their applicability to MPTs, Martha Brady and Heeyoung Park
Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection, Ines Frank and Melissa Robbiani
Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors, Rashad Hussain, Martine El-Etr, Ouardia Gaci, Jennifer Rakotomamonjy, Wendy B. Macklin, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, and Abdel M. Ghoumari
2011 IPM Annual Report—A Decade of Progress Advancing HIV Prevention for Women, International Partnership for Microbicides
Women and HIV/AIDS, International Partnership for Microbicides
Women and the need for microbicides, International Partnership for Microbicides
Validation of a dye stain assay for vaginally inserted hydroxyethylcellulose-filled microbicide applicators, Lauren L. Katzen, José Fernández-Romero, Avina Sarna, Kailapuri G. Murugavel, Daniel Gawarecki, Thomas Zydowsky, and Barbara Mensch
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani
Assessing the reporting of adherence and sexual activity in a simulated microbicide trial in South Africa: An interview mode experiment using a placebo gel, Barbara Mensch, Paul C. Hewett, Sharon Abbott, Johanna Rankin, Sarah A. Littlefield, Khatija Ahmed, Nazira Cassim, Smruti Patel, Gita Ramjee, Thesla Palanee, Stanley J. Mierzwa, and Stephanie Skoler-Karpoff
Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand, Sara J. Whitehead, Catherine A. McLean, Supaporn Chaikummao, Sarah Braunstein, Wat Utaivoravit, Janneke van de Wijgert, Philip A. Mock, Taweesap Siraprapasiri, Barbara Friedland, Peter H. Kilmarx, and Lauri Markowitz
Submissions from 2010
Expanded safety and acceptability of the candidate vaginal microbicide Carraguard® in South Africa, Lydia Altini, Kelly Blanchard, Nicol Coetzee, Alana de Kock, Christopher J. Elias, Charlotte Ellertson, Barbara Friedland, Anwar Hoosen, Heidi E. Jones, Peter H. Kilmarx, Mabitso Marumo, C. Elizabeth McGrory, Constance Monedi, Gugulethu Ndlovu, Bels Nkompala, Annalie Pistorius, Gita Ramjee, Mohlatlego Sebola, Annik Sorhaindo, Abigail Norris Turner, Kathryn Tweedy, Janneke van de Wijgert, Manuela M. Williams, and Beverly Winikoff
2010 IPM Annual Report—Building on Breakthroughs, International Partnership for Microbicides
HIV/AIDS and the Millennium Development Goals: Microbicides and the need for long-term prevention, International Partnership for Microbicides
Microbicides research: Hope for the future, benefits for today, International Partnership for Microbicides
Submissions from 2009
Effect of sexual intercourse on the absorption of levonorgestrel after vaginal administration of 0.75 mg in Carraguard® gel: A randomized, cross-over, pharmacokinetic study, Vivian Brache, Horacio B. Croxatto, Narender Kumar, Régine Sitruk-Ware, Leila Cochón, Veronica Schiappacasse, Irving Sivin, Carla Muñoz, Robin A. Maguire, and Anibal Faundes
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy, Federica Crostarosa, Meropi Aravantinou, Onome J. Akpogheneta, Edith Jasny, Andrew Shaw, Jessica Kenney, Michael Piatak Jr., Jeffrey D. Lifson, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Thomas M. Zydowsky, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
2009 IPM Annual Report—Microbicides: New Science, New Hope, International Partnership for Microbicides
Acceptability of a Carrageenan-based candidate vaginal microbicide and matching placebo: Findings from a Phase II safety trial among women in Chiang Rai, Thailand, Heidi E. Jones, Supaporn Chaikummao, Janneke van de Wijgert, Barbara Friedland, Chomnad Manopaiboon, Paisit Witwatwongwana, Mayuree Wankrairot, Nartlada Chantharojwong, and Peter H. Kilmarx
Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring, Joseph W. Romano, Bruce Variano, P. Coplan, J. Van Roey, K. Douville, Zeda Rosenberg, Marleen Temmerman, H. Verstraelen, L. Van Bortel, S. Weyers, and M. Mitchnick
Many vaginal microbicide trial participants acknowledged they had misreported sensitive sexual behavior in face-to-face interviews, Abigail Norris Turner, Alana de Kock, Amy Meehan-Ritter, Kelly Blanchard, Mohlatlego H. Sebola, Anwar Hoosen, Nicol Coetzee, and Charlotte Ellertson
Submissions from 2008
No increase in cervicovaginal proinflammatory cytokines after Carraguard use in a placebo-controlled randomized clinical trial, Liesbeth J.M. Bollen, Kelly Blanchard, Peter H. Kilmarx, Supaporn Chaikummao, Cathy Connolly, Punneporn Wasinrapee, Nucharee Srivirojana, Jullapong Achalapong, Jordan W. Tappero, and Janet M. McNicholl
A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells, Ines Frank, Hella Stössel, Agegnehu Gettie, Stuart G. Turville, Julian W. Bess, Jeffrey D. Lifson, Irving Sivin, Nikolaus Romani, and Melissa Robbiani
2008 IPM Annual Report—Progress on the Path to HIV Prevention, International Partnership for Microbicides
Microbicides Access Forum 2008, International Partnership for Microbicides
The use of antiretroviral drugs (ARVs) in microbicides and the potential for the development of drug-resistant strains of HIV, International Partnership for Microbicides
A randomized, placebo-controlled trial to assess the safety and acceptability of use of carraguard vaginal gel by heterosexual couples in Thailand, Peter H. Kilmarx, Kelly Blanchard, Supaporn Chaikummao, Barbara Friedland, Nucharee Srivirojana, Cathy Connolly, Paisit Witwatwongwana, Somsak Supawitkul, Philip A. Mock, Thanyanan Chaowanachan, and Jordan W. Tappero
Microbicide product development, Robin A. Maguire
Consentement éclairé dans les essais de prévention du VIH: Points saillants d'un atelier international, Population Council
Consentimento informado nos ensaios de prevenção do HIV: Pontos altos dum workshop internacional, Population Council
Consentimiento informado en ensayos de prevención del VIH: Aspectos destacados de un taller internacional, Population Council
Idhini fahamishi katika majaribio ya kikliniki ya ukingaji wa virusi vya ukimwi, Population Council
Imvume unolwazi ocwaningweni lokuvimbela igciwane lesandulela ngculaza, Population Council
Informed consent in HIV prevention trials: Highlights from an international workshop, Population Council
CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics, Andreas Schweizer, Peter Rusert, Livia Berlinger, Claudia R. Ruprecht, Axel Mann, Stéphanie Corthesy, Stuart G. Turville, Meropi Aravantinou, Marek Fischer, Melissa Robbiani, Patrick Amstutz, and Alexandra Trkola
Efficacy of Carraguard for prevention of HIV infection in women in South Africa: A randomised, double-blind, placebo-controlled trial, Stephanie Skoler-Karpoff, Gita Ramjee, Khatija Ahmed, Lydia Altini, Marlena Gehret Plagianos, Barbara Friedland, Sumen Govender, Alana de Kock, Nazira Cassim, Thesla Palanee, Gregory Dozier, Robin A. Maguire, and Pekka Lahteenmaki
Efficacy of Carraguard®-based microbicides in vivo despite variable in vitro activity, Stuart G. Turville, Meropi Aravantinou, Todd Miller, Jessica Kenney, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Thomas M. Zydowsky, Michael Piatak Jr., Julian W. Bess Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, and Melissa Robbiani
Differentiating normal from abnormal rates of genital epithelial findings in vaginal microbicide trials, Janneke van de Wijgert, Peter H. Kilmarx, Heidi E. Jones, John M. Karon, and Supaporn Chaikummao
Microbicides: Chemistry, structure, and strategy, Thomas Zydowsky
Submissions from 2007
Day of dialogue—Insights and evidence from product introduction: Lessons for microbicides, Martha Brady and C. Elizabeth McGrory
Planning for microbicide access in developing countries: Lessons from the introduction of contraceptive technologies, George F. Brown, Vimala Raghavendran, and Saul Walker
Carrageenan/MIV-150 (PC-815), a combination microbicide, José Fernández-Romero, Mitchell Thorn, Stuart G. Turville, Kanani Titchen, Kristin M. Sudol, Jifan Li, Todd Miller, Melissa Robbiani, Robin A. Maguire, Robert W. Buckheit Jr., Tracy L. Hartman, and David M. Phillips
2007 IPM Annual Report—Microbicides: Prevention Through Partnership, International Partnership for Microbicides
Engaging advocates from concept to results: Summary report of the Advocates' Consultation on HIV Prevention Trials: Carraguard and VOICE Studies, Johannesburg, South Africa, 18-19 October 2007, Microbicide Trials Network and Population Council
Acceptability of Carraguard, a candidate microbicide and methyl cellulose placebo vaginal gels among HIV-positive women and men in Durban, South Africa, Gita Ramjee, Neetha S. Morar, Sarah Braunstein, Barbara Friedland, Heidi E. Jones, and Janneke van de Wijgert
Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel: A new formulation for "dual protection" contraception, Régine Sitruk-Ware, Vivian Brache, Robin A. Maguire, Horacio B. Croxatto, Narender Kumar, Sushma Kumar, Juan Carlos Montero, Ana Maria Salvatierra, David M. Phillips, and Anibal Faundes
Carraguard vaginal gel safety in HIV-positive women and men in South Africa, Janneke van de Wijgert, Sarah Braunstein, Neetha S. Morar, Heidi E. Jones, Lorna Madurai, Tammy T. Evans Strickfaden, Manivasan Moodley, Jamila Aboobaker, Gugulethu Ndlovu, Taja M. Ferguson, Barbara Friedland, Clyde E. Hart, and Gita Ramjee
Determining the feasibility of utilizing the microbicide applicator compliance assay for use in clinical trials, Andrea R. Wallace, Aaron Teitelbaum, Livia Wan, Maria Gloria Mulima, Laura Guichard, Stephanie Skoler, Hlengiwe Vilakazi, Fridda S. Mapula, Jasmine Rossier, Sumentheran N. Govender, Pekka Lahteenmaki, Robin A. Maguire, and David M. Phillips
Submissions from 2006
2006 IPM Annual Report—Advancing HIV Prevention Options for Women, International Partnership for Microbicides
Safety and acceptability of the candidate microbicide carraguard in Thai women: Findings from a Phase II clinical trial, Peter H. Kilmarx, Janneke van de Wijgert, Supaporn Chaikummao, Heidi E. Jones, Khanchit Limpakarnjanarat, Barbara Friedland, John M. Karon, Chomnad Manopaiboon, Nucharee Srivirojana, Somboonsak Yanpaisarn, Somsak Supawitkul, Nancy L. Young, Philip A. Mock, Kelly Blanchard, and Timothy D. Mastro
Informed Consent in HIV Prevention Trials: Report of an International Workshop, C. Elizabeth McGrory, Barbara Friedland, Cynthia Woodsong, and Kathleen M. MacQueen
Challenges to microbicide introduction in South Africa, Phyllis Orner, Jane Harries, Diane Cooper, Jennifer Moodley, Margaret Hoffman, Julie Becker, C. Elizabeth McGrory, Rasha Dabash, and Hillary J. Bracken
Slamming the door on unwanted guests: Why preemptive strikes at the mucosa may be the best strategy against HIV, Susanna Trapp, Stuart G. Turville, and Melissa Robbiani
Lymphocyte–dendritic cell interactions and mucosal acquisition of SIV/HIV infection, Stuart G. Turville, Silvia Peretti, and Melissa Robbiani
Acceptability of Carraguard vaginal gel use among Thai couples, Sara J. Whitehead, Peter H. Kilmarx, Kelly Blanchard, Chomnad Manopaiboon, Supaporn Chaikummao, Barbara Friedland, Jullapong Achalapong, Mayuree Wankrairoj, Philip A. Mock, Sombat Thanprasertsuk, and Jordan W. Tappero
Submissions from 2005
Preferences and practices related to vaginal lubrication: Implications for microbicide acceptability and clinical testing, Sarah Braunstein and Janneke van de Wijgert
2005 IPM Annual Report—Developing HIV-Prevention Options for Women Worldwide, International Partnership for Microbicides
Phase III microbicide trial methodology: Opinions of experienced expanded safety trial participants in South Africa, Janneke van de Wijgert, Heidi E. Jones, Annalie Pistorius, Alana de Kock, Mohlatlego H. Sebola, Barbara Friedland, Anwar Hoosen, and Nicol Coetzee
Submissions from 2004
Paving the Path: Preparing for Microbicide Introduction—Report of a Qualitative Study in South Africa, Julie Becker, Rasha Dabash, C. Elizabeth McGrory, Diane Cooper, Jane Harries, Margaret Hoffman, Jennifer Moodley, Phyllis Orner, and Hillary J. Bracken
Paving the Path: Preparing for Microbicide Introduction—Report of a Qualitative Study in South Africa [Executive Summary], Julie Becker, Rasha Dabash, C. Elizabeth McGrory, Diane Cooper, Jane Harries, Margaret Hoffman, Jennifer Moodley, Phyllis Orner, and Hillary J. Bracken
Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue, Qinxue Hu, Ines Frank, Vennansha G. Williams, John J. Santos, Patricia Watts, George E. Griffin, John P. Moore, Melissa Robbiani, and Robin J. Shattock
2004 IPM Annual Report—Developing HIV-Prevention Options for Women Worldwide, International Partnership for Microbicides
Microbicide trials for preventing HIV/AIDS in South Africa: Phase II trial participants' experiences and psychological needs, Annalie Pistorius, Janneke van de Wijgert, Mohlatlego H. Sebola, Barbara Friedland, Evelyn Nagel, Cathleen Bokaba, and Anwar Hoosen
Assay for establishing whether microbicide applicators have been exposed to the vagina, Andrea R. Wallace, Mitchell Thorn, Robin A. Maguire, Kristin M. Sudol, and David M. Phillips
Submissions from 2003
Cultural norms and behavior regarding vaginal lubrication during sex: Implications for the acceptability of vaginal microbicides for the prevention of HIV/STIs, Sarah Braunstein and Janneke van de Wijgert
Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types, Thomas J. Ketas, Per Johan Klasse, Catherine Spenlehauer, Mirjana Nesin, Ines Frank, Melissa Robbiani, Julie M. Strizki, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore
Carrageenan formulation prevents macrophage trafficking from vagina: Implications for microbicide development, Maria-Elisa Perotti, Alessia Pirovano, and David M. Phillips
Transmission, acute HIV-1 infection and the quest for strategies to prevent infection, Melissa Robbiani and Ashley T. Haase
Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120, Ronald S. Veazey, Robin J. Shattock, Melissa Robbiani, J. Christian Kirijan, Jennifer Jones, Qinxue Hu, Thomas J. Ketas, Preston A. Marx, Per Johan Klasse, Dennis R. Burton, and John P. Moore
Submissions from 2002
Informed consent: From good intentions to sound practices—A report of a seminar, Susan Y. Wood, Barbara Friedland, and C. Elizabeth McGrory
Submissions from 2001
The case for microbicides: A global priority, Kathy Attawell
Submissions from 1998
A study of women's preferences regarding the formulation of over-the-counter vaginal spermicides, Christiana Coggins, Christopher J. Elias, Ronachai Atisook, Mary T. Bassett, Virginie Ettiegne-Traore, Peter D. Ghys, Laura Jenkins-Woelk, Earmporn Thongkrajai, and Nancy L. VanDevanter
Submissions from 1994
Partnership for prevention: A report of a meeting between women's health advocates, program planners, and scientists, Population Council
Submissions from 1993
The development of microbicides: A new method of HIV prevention for women, Christopher J. Elias and Lori L. Heise