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Submissions from 2019

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Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques, Giulia Calenda, Ines Frank, Geraldine Arrode-Bruses, Amarendra Pegu, Keyun Wang, James Arthos, Claudia Cicala, Kenneth A. Rogers, Lisa Shirreff, Brooke Grasperge, James L. Blanchard, Stephanie Maldonado, Kevin Roberts, Agegnehu Gettie, Francois Villinger, Anthony S. Fauci, John R. Mascola, and Elena Martinelli

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Mucosal susceptibility to human immunodeficiency virus infection in the proliferative and secretory phases of the menstrual cycle, Giulia Calenda, Guillermo Villegas, Alexandra Reis, Lily Millen, Patrick Barnable, Lisa Mamkina, Narender Kumar, Kevin Roberts, Tamara Kalir, Elena Martinelli, Rhoda Sperling, and Natalia Teleshova

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F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin, Haiqi Chen, Dolores D. Mruk, Chris K.C. Wong, Bruno Silvestrini, and C. Yan Cheng

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Bioactive fragments of laminin and collagen chains—Lesson from the testis, Huitao Li, Shiwen Liu, Siwen Wu, Linxi Li, Renshan Ge, and C. Yan Cheng

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Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization, Linxi Li, Baiping Mao, Ming Yan, Siwen Wu, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro study, Linxi Li, Siwen Wu, Ming Yan, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

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CAMSAP2 is a microtubule minus-end targeting protein (-TIP) that regulates BTB dynamics through cytoskeletal organization, Baiping Mao, Linxi Li, Renshan Ge, Chao Li, Chris K.C. Wong, Bruno Silvestrini, Qing-Quan Lian, and C. Yan Cheng

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis—Lesson from the adjudin model, Baiping Mao, Linxi Li, Ming Yan, Chris K.C. Wong, Bruno Silvestrini, Chao Li, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Comparative transcriptome analysis of the human endocervix and ectocervix during the proliferative and secretory phases of the menstrual cycle, Sampurna Mukhopadhyay, Y. Liang, H. Hur, Guillermo Villegas, Giulia Calenda, Alexandra Reis, Lily Millen, Patrick Barnable, Lisa Mamkina, Narender Kumar, Tamara Kalir, Rhoda Sperling, and Natalia Teleshova

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Kruppel-like factor 6 regulates Sertoli cell blood-testis barrier, Xiu-Xia Wang, Yan Zhang, Xiao-Yu Li, Jian Li, Ji-Xin Tang, Yuan-Yuan Li, Shou-Long Deng, C. Yan Cheng, and Yi-Xun Liu

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Myosin VIIa supports spermatid/organelle transport and cell adhesion during spermatogenesis in the rat testis, Qing Wen, Siwen Wu, Will M. Lee, Chris K.C. Wong, Wing-Yee Lui, Bruno Silvestrini, and C. Yan Cheng

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mTORC1/rpS6 and spermatogenic function in the testis—Insights from the adjudin model, Siwen Wu, Ming Yan, Linxi Li, Baiping Mao, Chris K.C. Wong, Renshan Ge, Qing-Quan Lian, and C. Yan Cheng

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Emerging role for SRC family kinases in junction dynamics during spermatogenesis, Xiang Xiao, Yue Yang, Baiping Mao, C. Yan Cheng, and Ya Ni

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mTORC1/rpS6 signaling complex that modifies BTB transport function—An in vivo study using the adjudin model, Ming Yan, Linxi Li, Baiping Mao, Huitao Li, Stephen Y.T. Li, Dolores D. Mruk, Bruno Silvestrini, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

Submissions from 2018

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A germline-specific role for the mTORC2 component Rictor in maintaining spermatogonial differentiation and intercellular adhesion in mouse testis, Shun Bai, Le Cheng, Yingwen Zhang, Chunsen Zhu, Zhiping Zhu, Ruping Zhu, C. Yan Cheng, Lan Ye, and Ke Zheng

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Integrin α_4β_7 blockade preferentially impacts CCR6^+ lymphocyte subsets in blood and mucosal tissues of naive rhesus macaques, Giulia Calenda, Rassamon Keawvichit, Geraldine Arrode-Bruses, Kovit Pattanapanyasat, Ines Frank, Siddappa Byrareddy, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Keith A. Reimann, Aftab A. Ansari, and Elena Martinelli

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Monitoring the integrity of the blood-testis barrier (BTB): An in vivo assay, Haiqi Chen, Wing-Yee Lui, Dolores D. Mruk, Xiang Xiao, Renshan Ge, Qing-Quan Lian, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Cell polarity and planar cell polarity (PCP) in spermatogenesis, Haiqi Chen, Dolores D. Mruk, Wing-Yee Lui, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng

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Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells, Shou-Long Deng, Zhi-Peng Wang, Cheng Jin, Xiao-Long Kang, Alia Batool, Yan Zhang, Xiao-Yu Li, Xiu-Xia Wang, Su-Ren Chen, Chawn-Shang Chang, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu

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SUMOylation regulates germinal vesicle break-down and the AKT/PKB pathway during mouse oocyte maturation, Weber Beringui Feitosa and Patricia L. Morris

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Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7, Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa Byrareddy, Philip J. Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D. Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A. Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S. Fauci, and James Arthos

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mTORC1/rpS6 regulates blood-testis barrier (BTB) dynamics and spermatogenetic function in the testis in vivo, Stephen Y.T. Li, Ming Yan, Haiqi Chen, Tito T. Jesus, Will M. Lee, Xiang Xiao, and C. Yan Cheng

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Regulation of blood–testis barrier assembly in vivo by germ cells, Xiao-Yu Li, Yan Zhang, Xiu-Xia Wang, Cheng Jin, Yu-Qian Wang, Tie-Cheng Sun, Ji-Xin Tang, Alia Batool, Shou-Long Deng, Su-Ren Chen, C. Yan Cheng, and Yi-Xun Liu

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Mechanistic insights into PFOS-mediated Sertoli cell injury, Baiping Mao, Dolores D. Mruk, Qing-Quan Lian, Renshan Ge, Chao Li, Bruno Silvestrini, and C. Yan Cheng

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MAdCAM costimulation through Integrin-α_4β_7 promotes HIV replication, Fatima Nawaz, Livia R. Goes, Jocelyn C. Ray, Ronke Olowojesiku, Alia Sajani, Aftab A. Ansari, Ian Perrone, Joseph Hiatt, Donald Van Ryk, Danlan Wei, Mia Waliszewski, Marcelo A. Soares, Katija Jelicic, Mark Connors, Stephen A. Migueles, Elena Martinelli, Francois Villinger, Claudia Cicala, Anthony S. Fauci, and James Arthos

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Male germ cells support long-term propagation of Zika virus, Christopher L. Robinson, Angie C.N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel, and Shuibing Chen

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Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis, Qing Wen, Nan Li, Xiang Xiao, Wing-Yee Lui, Darren S. Chu, Chris K.C. Wong, Qing-Quan Lian, Renshan Ge, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

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Cell polarity and cytoskeletons—Lesson from the testis, Qing Wen, Dolores D. Mruk, Elizabeth I. Tang, Chris K.C. Wong, Wing-Yee Lui, Will M. Lee, Xiang Xiao, Bruno Silvestrini, and C. Yan Cheng

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Signaling pathways regulating blood-tissue barriers—Lesson from the testis, Qing Wen, Elizabeth I. Tang, Ying Gao, Tito T. Jesus, Darren S. Chu, Will M. Lee, Chris K.C. Wong, Yi-Xun Liu, Xiang Xiao, Bruno Silvestrini, and C. Yan Cheng

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Regulation of blood-testis barrier (BTB) dynamics, role of actin-, and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Nan Li, Dolores D. Mruk, Will M. Lee, Bruno Silvestrini, and C. Yan Cheng

Submissions from 2017

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A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques, Meropi Aravantinou, Ines Frank, Geraldine Arrode-Bruses, Moriah Szpara, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Nina Derby, and Elena Martinelli

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Adjudin—A male contraceptive with anti-cancer, anti-neuroinflammation and anti-ototoxicity activities, Yan Ho Cheng, Weiliang Xia, Xiang Xiao, Elizabeth I. Tang, Haiqi Chen, Qing Wen, Ying Gao, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

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Focal adhesion kinase (FAK), Haiqi Chen and C. Yan Cheng

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Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant, Haiqi Chen, Ying Gao, Dolores D. Mruk, and C. Yan Cheng

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Drebrin and spermatogenesis, Haiqi Chen, Michelle W.M. Li, and C. Yan Cheng

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Regulation of spermatogenesis by a local functional axis in the testis: Role of the basement membrane–derived noncollagenous 1 domain peptide, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Human spermatogenesis and its regulation, Haiqi Chen, Dolores D. Mruk, Xiang Xiao, and C. Yan Cheng

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Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk

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Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system, Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C. Yan Cheng, Zheng-Xing Lian, and Yi-Xun Liu

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Basement membrane laminin α2 regulates BTB dynamics via its effects on F-actin- and microtubule (MT)-cytoskeletons via mTORC1 signaling, Ying Gao, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2, Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng

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Regulation of the blood–testis barrier by a local axis in the testis: Role of laminin α2 in the basement membrane, Ying Gao, Dolores D. Mruk, Haiqi Chen, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Mammalian target of rapamycin (mTOR): A central regulator of male fertility?, Tito T. Jesus, Pedro F. Oliveira, Mario Sousa, C. Yan Cheng, and Marco G. Alves

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Cell polarity, cell adhesion, and spermatogenesis: Role of cytoskeletons, Linxi Li, Ying Gao, Haiqi Chen, Tito T. Jesus, Elizabeth I. Tang, Nan Li, Qing-Quan Lian, Renshan Ge, and C. Yan Cheng

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Sperm release at spermiation is regulated by changes in the organization of actin- and microtubule-based cytoskeletons at the apical ectoplasmic specialization—A study using the adjudin model, Linxi Li, Elizabeth I. Tang, Haiqi Chen, Qing-Quan Lian, Renshan Ge, Bruno Silvestrini, and C. Yan Cheng

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Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with α-catenin at the blood–testis barrier, Dolores D. Mruk, Michele Bonanomi, and Bruno Silvestrini

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Emerging role for mammalian target of rapamycin in male fertility, Pedro F. Oliveira, C. Yan Cheng, and Marco G. Alves

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Abcb1a and Abcb1b genes function differentially in blood–testis barrier dynamics in the rat, Linlin Su, C. Yan Cheng, Will M. Lee, Min Zhang, Fangfang Yang, Bin Zhao, Daishu Han, Yixun Liu, and Dahai Hu

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MAP/Microtubule affinity-regulating kinase, Elizabeth I. Tang and C. Yan Cheng

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Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance, Kenneth S.K. Tung, Jessica Harakal, Hui Qiao, Claudia Rival, Jonathan C.H. Li, Alberta G.A. Paul, Karen Wheeler, Patcharin Pramoonjago, Constance M. Grafer, Wei Sun, Robert D. Sampson, Elissa W.P. Wong, Prabhakara P. Reddi, Umesh S. Deshmukh, Daniel M. Hardy, Huanghui Tang, C. Yan Cheng, and Erwin Goldberg

Submissions from 2016

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Planar cell polarity (PCP) proteins and spermatogenesis, Haiqi Chen and C. Yan Cheng

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Planar cell polarity (PCP) protein Vangl2 regulates ectoplasmic specialization dynamics via its effects on actin microfilaments in the testes of male rats, Haiqi Chen, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng

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Effective delivery of male contraceptives behind the blood-testis barrier (BTB)—Lesson from adjudin, Haiqi Chen, Dolores D. Mruk, Weiliang Xia, Michele Bonanomi, Bruno Silvestrini, and C. Yan Cheng

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The control of male fertility by spermatid-specific factors: Searching for contraceptive targets from spermatozoon’s head to tail, Su-Ren Chen, Alia Batool, Yu-Qian Wang, Xiao-Xia Hao, Chawn-Shang Chang, C. Yan Cheng, and Yi-Xun Liu

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Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication, Katarzyna Chojnacka, Barbara Bilinska, and Dolores D. Mruk

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Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells, Katarzyna Chojnacka, Marta Zarzycka, Anna Hejmej, Dolores D. Mruk, Ewelina Gorowska, Malgorzata Kotula-Balak, Monika Klimek, and Barbara Bilinska

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Biology of the Sertoli cell in the fetal, pubertal, and adult mammalian testis, Katarzyna Chojnacka, Marta Zarzycka, and Dolores D. Mruk

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Does cell polarity matter during spermatogenesis?, Ying Gao and C. Yan Cheng

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Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells, Ying Gao, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis, Ying Gao, Dolores D. Mruk, Wing-Yee Lui, Will M. Lee, and C. Yan Cheng

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Cell polarity proteins and spermatogenesis, Ying Gao, Xiang Xiao, Wing-Yee Lui, Will M. Lee, Dolores D. Mruk, and C. Yan Cheng

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Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells, Tito T. Jesus, Pedro F. Oliveira, Joaquina Silva, Alberto Barros, Rita Ferreira, Mario Sousa, C. Yan Cheng, Branca M. Silva, and Marco G. Alves

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Overexpression of plastin 3 in Sertoli cells disrupts actin microfilament bundle homeostasis and perturbs the tight junction barrier, Nan Li, Will M. Lee, and C. Yan Cheng

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Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43, Nan Li, Dolores D. Mruk, Haiqi Chen, Chris K.C. Wong, Will M. Lee, and C. Yan Cheng

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Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?, Nan Li, Dolores D. Mruk, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption, Nan Li, Dolores D. Mruk, Ka-Wai Mok, Michelle W.M. Li, Chris K.C. Wong, Will M. Lee, Daishu Han, Bruno Silvestrini, and C. Yan Cheng

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Formin 1 regulates microtubule and F-actin organization to support spermatid transport during spermatogenesis in the rat testis, Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Will M. Lee, Chris K.C. Wong, and C. Yan Cheng

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Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis, Nan Li, Chris K.C. Wong, and C. Yan Cheng

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Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal, Dolores D. Mruk

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Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis, Elizabeth I. Tang, Dolores D. Mruk, and C. Yan Cheng

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AKAP9, a regulator of microtubule dynamics, contributes to blood-testis barrier function, Deepak Venkatesh, Dolores D. Mruk, Jan M. Herter, Xavier Cullere, Katarzyna Chojnacka, C. Yan Cheng, and Tanya N. Mayadas

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Development, function and fate of fetal Leydig cells, Qing Wen, C. Yan Cheng, and Yi-Xun Liu

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Transport of germ cells across the seminiferous epithelium during spermatogenesis—The involvement of both actin- and microtubule-based cytoskeletons, Qing Wen, Elizabeth I. Tang, Xiang Xiao, Ying Gao, Darren S. Chu, Dolores D. Mruk, Bruno Silvestrini, and C. Yan Cheng

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Sertoli cell Wt1 regulates peritubular myoid cell and fetal leydig cell differentiation during fetal testis development, Qing Wen, Yuqian Wang, Ji-Xin Tang, C. Yan Cheng, and Yi-Xun Liu