Advances in our understanding of human spermatogenesis
Advances in molecular and cell biology, genetics, and biochemistry have brought new insights in understanding spermatogenesis, including in humans. In this review, we focus our discussion on a few areas of research, in particular during pre- and postmeiotic germ cell development, spermiogenesis, and the release of mature sperm at spermiation. We also discuss advances in the field regarding studies in humans in these areas of research. While most of the studies performed in the last decade are based on the use of rodent models, these findings have some implications in the clinic if these observations can be expanded to human males in the years to come. Furthermore, mutational analysis to correlate defects in spermatogenesis with specific genes in humans should also yield insights to understand the etiology of some unexplained male infertility.
Wen, Qing, Elizabeth I. Tang, Tito T. Jesus, Bruno Silvestrini, and C. Yan Cheng. 2018. "Advances in our understanding of human spermatogenesis," in C. Yan Cheng (eds.), Spermatogenesis.