Pre-eclampsia has two distinct subtypes: early onset pre-eclampsia, which occurs before 34 weeks of gestation, and late onset pre-eclampsia, which occurs after 34 weeks. Few studies examine and compare early and late onset pre-eclampsia in a low- and middle-income country setting. This study’s goal was to establish a profile of patients with hypertensive disorders in pregnancy, especially pre-eclampsia and eclampsia, over a two-year period. At Kenya’s national referral hospital, clinical presentation at admission was examined, as was management of complications, along with maternal and newborn health outcomes in the hospital’s maternity unit, to ascertain any differences in health outcomes for early and late onset pre-eclampsia. This report details the study’s findings, showing that out of the 620 records reviewed, 44 percent of pre-eclamptic and eclamptic women exhibited early onset of pre-eclampsia, while 56 percent had late onset. Early onset of pre-eclampsia was associated with greater disease severity as well as adverse maternal and perinatal outcomes. Early detection, continuous monitoring, identification of risk factors, and prompt referral are critical in mitigating the serious consequences of pre-eclampsia and eclampsia.
Ndwiga, Charity, Alfred Osoti, Pooja Sripad, George Odwe, Omondi Ogutu, and Charlotte E. Warren. 2018. "Retrospective cohort study: Clinical presentation and outcomes of pre-eclampsia and eclampsia at Kenyatta National Hospital, Nairobi, Kenya," Ending Eclampsia Final Study Report. Washington, DC: Population Council.