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Reproductive tract infections (RTIs) including sexually transmitted infections represent a silent worldwide pandemic that adversely impacts the reproductive health (RH) of women and men. Various community- and hospital-based studies in India have provided insights into the magnitude of the problem. The International Conference on Population and Development (1994) emphasized integration of RH services to meet the needs of men and women especially with prevention and management of RTIs/STIs. The emergence of HIV and the identification of STIs as a risk factor for the spread of HIV have further lent a sense of urgency for a programmatic response to address this public health problem. Programmatic evidence from developing countries indicates that integration of RTI/STI prevention and management with existing health services is both feasible and cost effective. The National Population Policy 2000 also highlights the need for programs that include provision of RTI/STI and HIV/AIDS prevention, screening, and management in RH care settings. This report reviews global and regional experiences and provides strategic directions likely to be the most effective in addressing these problems in India.