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It is well established that truckers (drivers and helpers) have higher rates of nonmarital sex than any other occupational group. Because of this multipartner sexual activity, truckers form a key group for HIV/STI prevention efforts. Thus far, HIV/STI prevention interventions for truckers have been geared to providing risk-reduction information and services within a heterosexual context. Recent evidence suggests that a large number of truckers engage in male-to-male (MSM) sexual activity that has serious implications for HIV/STI transmission. Therefore, information on the nature and extent of MSM activity among these populations is urgently needed for the design and implementation of comprehensive prevention programs. The Transport Corporation of India Foundation (TCIF) is implementing Project Kavach to reduce HIV/STI vulnerability in 1.5 million truckers and their partners. To design appropriate HIV/STI preventive strategies, TCIF requested that the Population Council undertake an exploratory study to fill in the gaps in the existing knowledge about the sexual behavior of truckers. As noted in this brief, this project’s main intervention is the provision of syndromic treatment for STIs and behavioral- change communication messages through Khushi Clinics at selected halt points.