People living with HIV (PLHIV) are at increased risk of developing active tuberculosis (TB) and dying from TB. Isoniazid preventive therapy (IPT) can prevent this, but only a small fraction of HIV-positive individuals are on IPT. Previous research suggests that clinical decision support systems (CDSS)—electronic systems that use existing patient data and established algorithms to generate alerts, reminders, or recommendations intended to aid clinical decision-making—have the potential to improve provider adherence to diagnostic and treatment guidelines. Researchers conducted a cluster randomized controlled trial of a new CDSS intervention for TB screening, prevention, and treatment in a high HIV and TB prevalence setting to evaluate the effects of implementing a reminder system for medical providers to increase IPT for PLHIV. Specifically, the research objective was to determine if the intervention increases IPT prescription rates and decreases time from initial encounter to IPT initiation. The study was conducted as part of the HIVCore project, funded by the U.S. Agency for International Development and led by the Population Council.
Green, Eric P., Caricia Catalani, Aggrey Keny, Lameck Diero, Charity Ndwiga, Dennis Israelski, and Paul Biondich. 2015. "Do clinical decision-support reminders for medical providers improve isoniazid prescription rates among HIV-positive adults?" Washington, DC: USAID | Project Search: HIVCore.
HIVCore: Strengthening HIV and AIDS Treatment, Care, and Support and PMTCT Service Delivery Programs