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Submissions from 2021

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Griffithsin and carrageenan combination results in antiviral synergy against SARS-CoV-1 and 2 in a pseudoviral model, Sahar Alsaidi, Nadjet Cornejal, Oneil Mahoney, Claudia Melo, Neeharika Verma, Thierry Bonnaire, Theresa Chang, Barry R. O'Keefe, James Sailer, Thomas Zydowsky, Natalia Teleshova, and José Fernández-Romero

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Sex differences in the cerebroprotection by Nestorone intranasal delivery following stroke in mice, Magalie Fréchou, Xiaoyan Zhu, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, Claudia Mattern, and Rachida Guennoun

Submissions from 2020

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Anti-α4β7 monoclonal antibody–conjugated nanoparticles block integrin α4β7 on intravaginal T cells in rhesus macaques, Sidi Yang, Geraldine Arrode-Bruses, Ines Frank, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, and Emmanuel A. Ho

Submissions from 2019

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A tat/rev induced limiting dilution assay to measure viral reservoirs in non-human primate models of HIV infection, Ines Frank, Arpan Acharya, Nanda K. Routhu, Meropi Aravantinou, Justin L. Harper, Stephanie Maldonado, Maria Sole Cigoli, Stanka Semova, Svetlana Mazel, Mirko Paiardini, Nina Derby, Siddappa Byrareddy, and Elena Martinelli

Submissions from 2018

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Therapeutic progestin segesterone acetate promotes neurogenesis: Implications for sustaining regeneration in female brain, Shuhua Chen, Narender Kumar, Zisu Mao, Régine Sitruk-Ware, and Roberta Diaz Brinton

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Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects, Alejandro De Nicola, Laura Garay, Maria Meyer, Rachida Guennoun, Régine Sitruk-Ware, Michael Schumacher, and Maria Claudia Gonzalez Deniselle

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Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo, Nina Derby, Manjari Lal, Meropi Aravantinou, Larisa Kizima, Patrick Barnable, Aixa Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R. O'Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José Fernández-Romero, and Thomas Zydowsky

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Non-clinical studies of progesterone, Régine Sitruk-Ware

Submissions from 2017

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Experimental oral herpes simplex virus-1 (HSV-1) co-infection in simian immunodeficiency virus (SIV)-infected rhesus macaques, Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, and Nina Derby

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MZC gel inhibits SHIV-RT and HSV-2 in macaque vaginal mucosa and SHIV-RT in rectal mucosa, Giulia Calenda, Guillermo Villegas, Patrick Barnable, Claudia Litterst, Keith Levendosky, Agegnehu Gettie, Michael Cooney, James Blanchard, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques, Nina Derby, Meropi Aravantinou, Jessica Kenney, Shweta Ugaonkar, Asa Wesenberg, Jolanta Wilk, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Olga Mizenina, Keith Levendosky, Michael Cooney, Samantha Seidor, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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Pixuna virus modifies host cell cytoskeleton to secure infection, Pedro Ignacio Gil, Guillermo Albrieu-Llinás, Estela Cecilia Mlewski, Marina Monetti, Laura Fozzatti, Cecilia Cuffini, José Fernández-Romero, Patricia Kunda, and Maria Gabriela Paglini

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MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1, Olga Mizenina, Mayla Hsu, Ninochka Jean-Pierre, Meropi Aravantinou, Keith Levendosky, Maria Gabriela Paglini, Thomas Zydowsky, Melissa Robbiani, and José Fernández-Romero

Submissions from 2016

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PolyICLC exerts pro- and anti-HIV effects on the DC-T cell milieu in vitro and in vivo, Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres M. Salazar, Michael Piatak Jr., Jeffrey D. Lifson, Melissa Robbiani, and Nina Derby

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A small molecule, which competes with MAdCAM-1, activates integrin α4β7 and fails to prevent mucosal transmission of SHIV-SF162P3, Geraldine Arrode-Bruses, Diana J. Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, and Elena Martinelli

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Rectal HSV-2 infection may increase rectal SIV acquisition even in the context of SIVΔnef vaccination, Natalia Guerra-Perez, Meropi Aravantinou, Filippo Veglia, Diana J. Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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A novel microbicide/contraceptive intravaginal ring protects macaque genital mucosa against SHIV-RT infection ex vivo, Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael Cooney, Melissa Robbiani, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

Submissions from 2015

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MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model, Patrick Barnable, Giulia Calenda, Thierry Bonnaire, Radhika Menon, Keith Levendosky, Agegnehu Gettie, James F. Blanchard, Michael Cooney, José Fernández-Romero, Thomas Zydowsky, and Natalia Teleshova

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Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex, Martine El-Etr, Marion Rame, Celine Boucher, Abdel M. Ghoumari, Narender Kumar, Philippe Liere, Antoine Pianos, Michael Schumacher, and Régine Sitruk-Ware

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Preclinical assessments of vaginal microbicide candidate safety and efficacy, José Fernández-Romero, Natalia Teleshova, Thomas Zydowsky, and Melissa Robbiani

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Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus, Keith Levendosky, Olga Mizenina, Elena Martinelli, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Kyle Kleinbeck, Thierry Bonnaire, Melissa Robbiani, Thomas Zydowsky, Barry R. O'Keefe, and José Fernández-Romero

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An intravaginal ring for the simultaneous delivery of an HIV-1 maturation inhibitor and reverse-transcriptase inhibitor for prophylaxis of HIV transmission, Shweta Ugaonkar, Justin T. Clark, Lexie B. English, Todd J. Johnson, Karen W. Buckheit, Robert J. Bahde, Daniel H. Appella, Robert W. Buckheit Jr., and Patrick F. Kiser

Submissions from 2014

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A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants, Patrick Barnable, Giulia Calenda, Louise Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodriguez, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Michael Cooney, Kevin Roberts, Rhoda Sperling, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, Melissa Robbiani, and Natalia Teleshova

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Microbicidas para la prevención de infecciones de transmisión sexual: estado actual y estrategias para la evaluación preclínica de nuevos candidatos, José Fernández-Romero, Pedro I. Gil, Viviana Re, Melissa Robbiani, and Gabriela Paglini

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Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis, Laura Garay, Maria Claudia Gonzalez Deniselle, Régine Sitruk-Ware, Rachida Guennoun, Michael Schumacher, and Alejandro De Nicola

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Sex hormones selectively impact the endocervical mucosal microenvironment: Implications for HIV transmission, Diana J. Goode, Meropi Aravantinou, Sebastian Jarl, Rosaline Truong, Nina Derby, Natalia Guerra-Perez, Jessica Kenney, James Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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HSV-2-driven increase in the expression of α_4β_7 correlates with increased susceptibility to vaginal SHIV_SF162P3 infection, Diana J. Goode, Rosaline Truong, Guillermo Villegas, Giulia Calenda, Natalia Guerra-Perez, Michael Piatak Jr., Jeffrey D. Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani, and Elena Martinelli

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Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits, Carolien Grammen, Myriam Baes, Steven Haenen, Jasper Verguts, Koen Augustyns, Thomas Zydowsky, Paolo La Colla, Patrick Augustijns, and Joachim Brouwers

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A combination microbicide gel protects macaques against vaginal SHIV-RT infection, but only partially reduces HSV-2 infection after a single high-dose co-challenge, Mayla Hsu, Meropi Aravantinou, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Nina Derby, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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Short communication: A repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides, Jessica Kenney, Nina Derby, Meropi Aravantinou, Kyle Kleinbeck, Ines Frank, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, Thomas Zydowsky, and Melissa Robbiani

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MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection, Louise Ouattara, Patrick Barnable, Paul Mawson, Samantha Seidor, Thomas Zydowsky, Larisa Kizima, Aixa Rodriguez, José Fernández-Romero, Michael Cooney, Kevin Roberts, Agegnehu Gettie, James Blanchard, Melissa Robbiani, and Natalia Teleshova

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A novel intravaginal ring (IVR) protects macaques against SHIV-RT infection and reduces HSV-2 shedding after repeated SHIV-RT/HSV-2 co-challenge, Thomas Zydowsky, Jessica Kenney, Meropi Aravantinou, Shweta Ugaonkar, Nina Derby, Larisa Kizima, Shimin Zhang, Olga Mizenina, José Fernández-Romero, and Melissa Robbiani

Submissions from 2013

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The frequency of α4β7high memory CD4+ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection, Elena Martinelli; Filippo Veglia; Diana J. Goode; Natalia Guerra-Perez; Meropi Aravantinou; James Arthos; Michael Piatak, Jr.; Jeffrey D. Lifson; James Blanchard; Agegnehu Gettie; and Melissa Robbiani

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Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary, Shanmugasundaram Nallasamy, Jaeyeon Kim, Régine Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi

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Simian immunodeficiency virus interactions with macaque dendritic cells, Natalia Teleshova, Nina Derby, Elena Martinelli, Pavel Pugach, Giulia Calenda, and Melissa Robbiani

Submissions from 2012

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The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection, Meropi Aravantinou, Rachel Singer, Nina Derby, Giulia Calenda, Paul Mawson, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Daniel Goldman, Jessica Kenney, Guillermo Villegas, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, Natalia Teleshova, and Melissa Robbiani

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Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy, Edith Jasny, Suzanne Geer, Ines Frank, Panagiotis Vagenas, Meropi Aravantinou, Andres M. Salazar, Jeffrey D. Lifson, Michael Piatak Jr., Agegnehu Gettie, James L. Blanchard, and Melissa Robbiani

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A single dose of a MIV-150/zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use, Jessica Kenney, Rachel Singer, Nina Derby, Meropi Aravantinou, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Shimin Zhang, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques, Rachel Singer, Paul Mawson, Nina Derby, Aixa Rodriguez, Larisa Kizima, Radhika Menon, Daniel Goldman, Jessica Kenney, Meropi Aravantinou, Samantha Seidor, Agegnehu Gettie, James Blanchard, Michael Piatak Jr., Jeffrey D. Lifson, José Fernández-Romero, Melissa Robbiani, and Thomas Zydowsky

Submissions from 2011

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Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors, Rashad Hussain, Martine El-Etr, Ouardia Gaci, Jennifer Rakotomamonjy, Wendy B. Macklin, Narender Kumar, Régine Sitruk-Ware, Michael Schumacher, and Abdel M. Ghoumari

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An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques, Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas, Takeshi Maruo, Noriyuki Ohara, Shigeki Yoshida, Koji Nakabayashi, Hiroko Sasaki, Qin Xu, Hiroya Matsuo, Régine Sitruk-Ware, and Hideto Yamada

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The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques, Rachel Singer, Nina Derby, Aixa Rodriguez, Larisa Kizima, Jessica Kenney, Meropi Aravantinou, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D. Lifson, Michael Piatak Jr., José Fernández-Romero, Thomas Zydowsky, and Melissa Robbiani

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7 α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: A preclinical study in the aged male orchidectomized rat model, M. Sinnesael, F. Callewaert, M. Morreels, Narender Kumar, Régine Sitruk-Ware, K. van Proeyen, P. Hespel, Steven Boonen, F. Claessens, and Dirk Vanderschueren

Submissions from 2010

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Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques, Robert M. Brenner, Ov D. Slayden, Anita Nath, Yun-yen Tsong, and Régine Sitruk-Ware

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A tonsillar polyICLC/At-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation, Panagiotis Vagenas, Meropi Aravantinou, Vennansha G. Williams, Edith Jasny, Michael Piatak Jr., Jeffrey D. Lifson, Andres M. Salazar, James Blanchard, Agegnehu Gettie, and Melissa Robbiani