Title

Bioactive fragments of laminin and collagen chains—Lesson from the testis

Document Type

Article (peer-reviewed)

Publication Date

2019

Abstract

Recent studies have shown that the testis is producing several biologically active peptides, namely the F5- and the NC1-peptides from laminin-γ3 and collagen α3 (IV) chain, respectively, that promotes blood-testis barrier (BTB) remodeling and also elongated spermatid release at spermiation. Also the LG3/4/5-peptide from laminin-α2 chain also promotes BTB integrity which is likely being used for the assembly of a “new” BTB behind preleptotene spermatocytes under transport at the immunological barrier. These findings thus provides a new opportunity for investigators to better understand the biology of spermatogenesis. Herein, we briefly summarize these recent findings and provide a critique update and a hypothetical model which can serve as the framework for studies in the years to come.

DOI

10.1530/REP-19-0288

Language

English

Project

The Biology of Blood–Testis Barrier Dynamics

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