Bioactive fragments of laminin and collagen chains—Lesson from the testis
Recent studies have shown that the testis is producing several biologically active peptides, namely the F5- and the NC1-peptides from laminin-γ3 and collagen α3 (IV) chain, respectively, that promotes blood-testis barrier (BTB) remodeling and also elongated spermatid release at spermiation. Also the LG3/4/5-peptide from laminin-α2 chain also promotes BTB integrity which is likely being used for the assembly of a “new” BTB behind preleptotene spermatocytes under transport at the immunological barrier. These findings thus provides a new opportunity for investigators to better understand the biology of spermatogenesis. Herein, we briefly summarize these recent findings and provide a critique update and a hypothetical model which can serve as the framework for studies in the years to come.
Li, Huitao, Shiwen Liu, Siwen Wu, Linxi Li, Renshan Ge, and C. Yan Cheng. 2020. "Bioactive fragments of laminin and collagen chains—Lesson from the testis," Reproduction 159(3): R111–R123.
The Biology of Blood–Testis Barrier Dynamics