Title

The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics

Document Type

Article (peer-reviewed)

Publication Date

2012

Abstract

Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.

DOI

10.1007/s00018-011-0760-0

Language

English

Project

The Biology of Blood–Testis Barrier Dynamics

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