The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics
Document Type
Article (peer-reviewed)
Publication Date
2012
Abstract
Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
Recommended Citation
Lie, Pearl P.Y., C. Yan Cheng, and Dolores D. Mruk. 2012. "The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics," Cellular and Molecular Life Sciences 69(4): 487–500.
DOI
10.1007/s00018-011-0760-0
Language
English
Project
The Biology of Blood–Testis Barrier Dynamics