The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics
Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
Lie, Pearl P.Y., C. Yan Cheng, and Dolores D. Mruk. 2012. "The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics," Cellular and Molecular Life Sciences 69(4): 487–500.
The Biology of Blood–Testis Barrier Dynamics