Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells
Document Type
Article (peer-reviewed)
Publication Date
2003
Abstract
Inhibitors of human immunodeficiency virus type 1 attachment (CD4-immunoglobulin G subclass 2), CCR5 usage (PRO 140), and fusion (T-20) were tested on diverse primary cell types that represent the major targets both for infection in vivo and for the inhibition of trans infection of target cells by virus bound to dendritic cells. Although minor cell-type-dependent differences in potency were observed, each inhibitor was active on each cell type and trans infection was similarly vulnerable to inhibition at each stage of the fusion cascade.
Recommended Citation
Ketas, Thomas J., Ines Frank, Per Johan Klasse, Brian M. Sullivan, Jason P. Gardener, Catherine Spenlehauer, Mirjana Nesin, William C. Olson, John P. Moore, and Melissa Robbiani. 2003. "Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells," Journal of Virology 77(4): 2762–2767.
DOI
10.1128/JVI.77.4.2762-2767.2003
Language
English
https://doi.org/10.1128/JVI.77.4.2762-2767.2003