Title

The functional roles of 11β-HSD1: Vascular tissue, testis and brain

Document Type

Article (peer-reviewed)

Publication Date

2003

Abstract

Glucocorticoid hormones bind both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) exerting a broad spectrum of actions in various tissues. The concentrations of glucocorticoid hormones in the target cells are regulated by 11β-hydroxysteroid dehydrogenases, type 1 (11β-HSD1) and type 2 (11β-HSD2). 11β-HSD2 is a unidirectional dehydrogenase, which inactivates biologically active glucocorticoid into inert metabolite, while 11β-HSD1 is a bi-directional oxidoreductase, which either inactivates biologically active glucocorticoid or activates inert metabolite into active forms. GRs and MRs are present in various tissues and mediate a broad spectrum of physiological actions. The co-existence of 11β-HSD1 with these two types of receptors plays an important role in regulation of glucocorticoid actions. This review examines the roles of 11β-HSD1 in vascular tissues, testis, brain and other tissues such as placental, retinal and adipose tissues.

DOI

10.1016/S0303-7207(03)00094-7

Language

English

https://doi.org/10.1016/S0303-7207(03)00094-7

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