The Adolescent Girls Empowerment Program (AGEP) in rural and urban Zambia aims to build social, health, and economic assets of adolescent girls. A safe spaces component is at the core of AGEP. Girls groups, under the guidance of a female mentor from the same community, provide a safe and supportive learning environment. The meetings are critical in building social assets for vulnerable girls—including friendships, self-esteem, trusting relationships with adults, and social support. The training content over the course of the year varies from sexual and reproductive health and life skills to financial education and nutrition training. This curriculum aimed to increase adolescent girls’ knowledge of reproductive health and sexuality; reinforce and promote attitudes and behaviors that will lead to a better quality of life for adolescent girls; and instill skills among adolescents to enable them to overcome the challenges of growing up and becoming responsible adults. These skills include communication skills, decision-making, assertiveness, setting goals, and resisting peer pressure.