The Abriendo Oportunidades program aims to support indigenous girls in Guatemala to reach their maximum potential and overcome the cycle of poverty. The program created safe spaces for girls at the community level, reaching adolescent girls with an asset-based curriculum implemented by community mentors. This is the third version of the curriculum. It was designed to foster reflection and dialogue, sisterhood, and critical thinking among adolescent girls. The first two versions focused on reproductive health, nutrition, hygiene, communication skills, and financial education. Several of the initial topics, as well as some activities from these previous versions, are included in the current version. The guide is a valuable tool for programs seeking to integrate comprehensive sexuality education and the prevention of violence into their approach.