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This document presents highlights from the UNICEF Adolescent Development and Participation (ADAP) Baseline Study in Nepal, which aims to ensure the systematic, ethical, meaningful, and regular participation of adolescents and focuses on vulnerable and disadvantaged groups. The program aims to empower adolescents, especially girls, to initiate and sustain activities and interventions that create positive transformation in their families, communities, and society, and bring about realization of their rights. The Population Council and partners led a study to develop a research design and implement a baseline survey to inform UNICEF’s ADAP program. The primary aim is to inform the program with adequate and scientifically valid data on adolescents from the program coverage districts. To accomplish this, the study measured the sociocultural and behavioral aspects of the lives of Nepali adolescents in 15 districts of the Terai and Far and Mid Western regions in UNICEF’s six domains of holistic adolescent development: Education and Skills; Livelihoods and Financial Literacy; Enabling and Protective Environment; Gender Norms and Gender Equity; Health and Healthy Behaviors, and Participation and Civic Engagement.