Title

Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3

Document Type

Article (peer-reviewed)

Publication Date

2010

Abstract

Non-steroidal compounds that inhibit 17β-hydroxysteroid dehydrogenase isoform 3 (17β-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17β-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.

DOI

10.1016/j.bmcl.2010.02.089

Language

English

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