Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3
Non-steroidal compounds that inhibit 17β-hydroxysteroid dehydrogenase isoform 3 (17β-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17β-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.
Hu, Guo-Xin, Guang Liang, Yanhui Chu, Xiao-Kun Li, Qing-Quan Lian, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, and Renshan Ge. 2010. "Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3," Bioorganic and Medicinal Chemistry Letters 20(8): 2549–2551.