Title

Spermatogenesis, Mammals

Document Type

Chapter

Publication Date

2013

Abstract

Spermatogenesis occurs in the seminiferous tubule of the testis to produce millions of spermatozoa per day, with each spermatozoon containing a haploid complement of chromosomes. It is precisely regulated by two hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), secreted from the pituitary gland under the influence of gonadotropin-releasing hormone (GnRH) from the hypothalamus at the hypothalamic-pituitary-testicular axis. It is also regulated by testosterone released from Leydig cells found in the interstitial space and by estradiol-17β released from Sertoli and germ cells in the seminiferous epithelium. Furthermore, spermatogenesis is regulated by a local functional axis, known as the apical ectoplasmic specialization (apical ES)-blood-testis barrier (BTB)-basement membrane axis, that coordinates different cellular events across the seminiferous epithelium during spermatogenesis.

DOI

10.1016/B978-0-12-374984-0.01459-5

Language

English

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